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Grant Details

Grant Number: 5R01CA077856-04 Interpret this number
Primary Investigator: Ahluwalia, Jasjit
Organization: University Of Kansas Medical Center
Project Title: Does Bupropion Help African Americans Quit Smoking?
Fiscal Year: 2000
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Abstract

The primary aim of this study is to assess the incremental benefit of adjuvant behavioral therapy with the transdermal nicotine patch (TNP) for smoking cessation in inner-city African Americans. This 4 year randomized intervention trial will be conducted at two community-based clinics. The primary outcome of the study is biochemically-verified continuous abstinence from cigarettes at 6 months from the end-of-treatment. Secondary outcomes include 1) continuous, 30-day, and 7-day abstinence at one year; 2) differences among, and within, the three groups in advancing along the stages of change continuum; and, 3) cost-effectiveness, as measured by cost-per-successful quitter. This two arm study has one comparison group (c) and one intervention group (Tx1). Group 1 (Comparison = C) will receive usual care, typical of a primary care setting, consisting of brief physician advice and a previously developed culturally-sensitive smoking cessation guide written at the sixth grade reading level (Pathways to Freedom). Group 2 (Boosted Self-Help = Tx1) will receive the same as C with the addition of a culturally-sensitive smoking cessation video (Kick-It!), a baseline individual counseling session, and four stage-based booster phone calls, the goals of which are, to encourage quitting, to increase use of the written and audiovisual materials, and to maintain compliance with TNP. There will be six data collection points: 1) at screening, in person; 2) at baseline, in person; 3) at 6 weeks, in person; 4) at 10 weeks (the end-of-treatment), by telephone; 5) at six months, in person; and, 6) at one year, by telephone. Recruitment and retention of subjects will be enhanced by phone and mailed reminders to pick up remaining TNP at six weeks and to return for the six month visit, by a monetary stipend for return at the sixth month visit, and by home visits at six months for no shows. The intervention groups have been designed so that efficacy, durability, and generalizabilty, can be accurately measured and assessed. This randomized controlled trial will use the patient as the unit of randomization and analysis. We project that 400 smokers for C, and 400 for Tx1, a total of 800 patients, will be required at baseline to detect proposed treatment effects for the primary outcome with a power of 80%. Ultimately, we envision that the interventions, if efficacious, could be used as a pre-packaged intervention and be distributed at settings such as churches and social service agencies.

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Publications

The impact of perceived treatment assignment on smoking cessation outcomes among African-American smokers.
Authors: Thomas J.L. , Guo H. , Lynam I.M. , Powell J.N. , Okuyemi K.S. , Bronars C.A. , Ahluwalia J.S. .
Source: Journal of general internal medicine, 2008 Sep; 23(9), p. 1361-6.
EPub date: 2008-06-29.
PMID: 18587620
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The influence of depressive symptoms on smoking cessation among African Americans in a randomized trial of bupropion.
Authors: Catley D. , Harris K.J. , Okuyemi K.S. , Mayo M.S. , Pankey E. , Ahluwalia J.S. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2005 Dec; 7(6), p. 859-70.
PMID: 16298721
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Stress and quitting among African American smokers.
Authors: Manning B.K. , Catley D. , Harris K.J. , Mayo M.S. , Ahluwalia J.S. .
Source: Journal of behavioral medicine, 2005 Aug; 28(4), p. 325-33.
PMID: 16049631
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Self-efficacy and motivation to quit during participation in a smoking cessation program.
Authors: Boardman T. , Catley D. , Mayo M.S. , Ahluwalia J.S. .
Source: International journal of behavioral medicine, 2005; 12(4), p. 266-72.
PMID: 16262545
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Healthcare providers' treatment of college smokers.
Authors: Koontz J.S. , Harris K.J. , Okuyemi K.S. , Mosier M.C. , Grobe J. , Nazir N. , Ahluwalia J.S. .
Source: Journal of American college health : J of ACH, 2004 Nov-Dec; 53(3), p. 117-25.
PMID: 15571114
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Predictors of smoking cessation among African-Americans enrolled in a randomized controlled trial of bupropion.
Authors: Harris K.J. , Okuyemi K.S. , Catley D. , Mayo M.S. , Ge B. , Ahluwalia J.S. .
Source: Preventive medicine, 2004 Apr; 38(4), p. 498-502.
PMID: 15020185
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Does menthol attenuate the effect of bupropion among African American smokers?
Authors: Okuyemi K.S. , Ahluwalia J.S. , Ebersole-Robinson M. , Catley D. , Mayo M.S. , Resnicow K. .
Source: Addiction (Abingdon, England), 2003 Oct; 98(10), p. 1387-93.
PMID: 14519175
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Successful recruitment of minorities into clinical trials: The Kick It at Swope project.
Authors: Harris K.J. , Ahluwalia J.S. , Catley D. , Okuyemi K.S. , Mayo M.S. , Resnicow K. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003 Aug; 5(4), p. 575-84.
PMID: 12959796
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Sustained-release bupropion for smoking cessation in African Americans: a randomized controlled trial.
Authors: Ahluwalia J.S. , Harris K.J. , Catley D. , Okuyemi K.S. , Mayo M.S. .
Source: JAMA, 2002 Jul 24-31; 288(4), p. 468-74.
PMID: 12132977
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Participation of African Americans in a smoking cessation trial: a quantitative and qualitative study.
Authors: Woods M.N. , Harris K.J. , Mayo M.S. , Catley D. , Scheibmeir M. , Ahluwalia J.S. .
Source: Journal of the National Medical Association, 2002 Jul; 94(7), p. 609-18.
PMID: 12126287
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African American smokers interested and eligible for a smoking cessation clinical trial: predictors of not returning for randomization.
Authors: Ahluwalia J.S. , Richter K. , Mayo M.S. , Ahluwalia H.K. , Choi W.S. , Schmelzle K.H. , Resnicow K. .
Source: Annals of epidemiology, 2002 Apr; 12(3), p. 206-12.
PMID: 11897179
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Smoking behaviors and regular source of health care among African Americans.
Authors: Ahluwalia J.S. , Dang K.S. , Choi W.S. , Harris K.J. .
Source: Preventive medicine, 2002 Mar; 34(3), p. 393-6.
PMID: 11902858
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Light smokers: issues and recommendations.
Authors: Okuyemi K.S. , Harris K.J. , Scheibmeir M. , Choi W.S. , Powell J. , Ahluwalia J.S. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2002; 4 Suppl 2, p. S103-12.
PMID: 12573172
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Smoking in urban African Americans: behaviors, gender differences, and motivation to quit.
Authors: Woods M.N. , Harris K.J. , Ahluwalia J.S. , Schmelzle K.H. , Mayo M.S. .
Source: Ethnicity & disease, 2001 Autumn; 11(3), p. 532-9.
PMID: 11572418
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Documentation of smoking: role of age, gender, and ethnicity.
Authors: Okuyemi K.S. , Harris K.J. , Ahluwalia J.S. , Wallace D.D. .
Source: Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians, 2001 Jul; 12(3), p. 125-8.
PMID: 11851200
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Pharmacotherapy of smoking cessation.
Authors: Okuyemi K.S. , Ahluwalia J.S. , Harris K.J. .
Source: Archives of family medicine, 2000 Mar; 9(3), p. 270-81.
PMID: 10728115
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Smoking status as a vital sign.
Authors: Ahluwalia J.S. , Gibson C.A. , Kenney R.E. , Wallace D.D. , Resnicow K. .
Source: Journal of general internal medicine, 1999 Jul; 14(7), p. 402-8.
PMID: 10417597
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Knowledge about smoking, reasons for smoking, and reasons for wishing to quit in inner-city African Americans.
Authors: Ahluwalia J.S. , Resnicow K. , Clark W.S. .
Source: Ethnicity & disease, 1998 Autumn; 8(3), p. 385-93.
PMID: 9926909
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