Grant Details
Grant Number: |
5R01CA074413-04 Interpret this number |
Primary Investigator: |
Herrick, Robert |
Organization: |
Harvard University (Sch Of Public Hlth) |
Project Title: |
Identification and Control of Cancer Risk |
Fiscal Year: |
2000 |
Abstract
DESCRIPTION: (Adapted from Applicant's Abstract). The major goal of this
study is to test the hypothesis that the excess cancer risk among asphalt
workers is a result of their occupational exposure, and to assess the role
of asphalt exposure as a cancer risk. In addition to investigating the
degree to which the observed marker for cancer risk is attributable to
occupational asphalt exposure, the relative importance of inhalation and
dermal routes of exposure will be assessed to provide the basis for an
intervention strategy to reduce that risk. There have been approximately 20
epidemiologic studies done on cancer risk among roofers and highway
maintenance workers, and excess risk of cancer for several sites (lung,
stomach, non-melanoma skin, and leukemias) have been reported with roofers
consistently demonstrating greater risks than highway maintenance workers.
Occupational exposure to PAHs has been proposed to explain the excess risk
in these two groups, but no detailed exposure assessments have been done to
support this association.
The plan is to conduct a prospective study, including comprehensive
assessment of exposure, to examine the association between exposure to PAH
and a biological marker of carcinogen damage in the form of PAH-DNA adducts.
The proposed research will: 1) recruit a population of at least 100 workers
employed in roofing and highway paving with a range of asphalt exposures; 2)
conduct a comprehensive evaluation of their occupational PAH exposure using
their work task as the central organizing principle of the exposure
assessment; 3) develop a task-based model for estimating the PAH exposures
during the one-year prospective study; 4) measure the change in PAH-DNA
adduct levels in mononuclear cells of these workers over the working year;
5) evaluate by linear regression the contribution of dermal and respiratory
PAH exposure, smoking, diet and other factors to the level of PAH-DNA
adducts; 6) develop an intervention strategy to reduce the risk of cancer
resulting from occupational PAH exposures, using the information on the
relative significance of inhalation and dermal exposure and the
task-specific measures of exposure.
Publications
Biomarker Variance Component Estimation For Exposure Surrogate Selection And Toxicokinetic Inference
Authors: Sobus J.R.
, Pleil J.D.
, McClean M.D.
, Herrick R.F.
, Rappaport S.M.
.
Source: Toxicology Letters, 2010-12-15 00:00:00.0; 199(3), p. 247-53.
PMID: 20851754
Related Citations
Dermal Exposure And Urinary 1-hydroxypyrene Among Asphalt Roofing Workers
Authors: McClean M.D.
, Rinehart R.D.
, Sapkota A.
, Cavallari J.M.
, Herrick R.F.
.
Source: Journal Of Occupational And Environmental Hygiene, 2007; 4 Suppl 1, p. 118-26.
PMID: 17503278
Related Citations
Physical And Chemical Characterization Of Asphalt (bitumen) Paving Exposures
Authors: Herrick R.F.
, McClean M.D.
, Meeker J.D.
, Zwack L.
, Hanley K.
.
Source: Journal Of Occupational And Environmental Hygiene, 2007; 4 Suppl 1, p. 209-16.
PMID: 17503286
Related Citations
Urinary 1-hydroxypyrene And Polycyclic Aromatic Hydrocarbon Exposure Among Asphalt Paving Workers
Authors: McClean M.D.
, Rinehart R.D.
, Ngo L.
, Eisen E.A.
, Kelsey K.T.
, Wiencke J.K.
, Herrick R.F.
.
Source: The Annals Of Occupational Hygiene, 2004 Aug; 48(6), p. 565-78.
PMID: 15292037
Related Citations
Laboratory Evaluation Of A Potential Diesel Fuel Interference In The Determination Of Polycyclic Aromatic Compounds On Dermal Samplers
Authors: Weker R.A.
, Herrick R.F.
, Rinehart R.D.
.
Source: Journal Of Occupational And Environmental Hygiene, 2004 May; 1(5), p. 334-42.
PMID: 15238342
Related Citations
Dna Strand Breaks, Oxidative Damage, And 1-oh Pyrene In Roofers With Coal-tar Pitch Dust And/or Asphalt Fume Exposure
Authors: Toraason M.
, Hayden C.
, Marlow D.
, Rinehart R.
, Mathias P.
, Werren D.
, Olsen L.D.
, Neumeister C.E.
, Mathews E.S.
, Cheever K.L.
, et al.
.
Source: International Archives Of Occupational And Environmental Health, 2001 Aug; 74(6), p. 396-404.
PMID: 11563602
Related Citations