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Grant Details

Grant Number: 5R01CA071378-05 Interpret this number
Primary Investigator: Hall, Sharon
Organization: Univ Of California At San Francisco
Project Title: Brief Versus Extended Smoking Treatment
Fiscal Year: 2000


DESCRIPTION: (Applicant's Description) The overall goals of this smoking cessation research are: 1) to understand the factors causing relapse to cigarettes, and 2) to design and evaluate treatments based on that understanding. In a 2 X 2 factorial design, where all subjects are receiving nicotine gum, the proposed research will test a series of hypotheses about the clinical efficacy, the cost, and the cost effectiveness of brief versus extended treatment, and of medical management alone versus medical management plus psychosocial support. In the brief treatment conditions, subjects will be treated for three months. In the extended treatment conditions, subjects will be treated for one year, which will include year long access to nicotine gum. This study has three interrelated foci: The first is to determine the relative efficacy of brief versus extended treatment in assisting smoking cessation; the second is to determine the relative efficacy of the two levels of psychosocial intervention (medical management alone vs. medical management plus psychosocial support) in assisting smoking cessation; and the third is to compare the cost and the cost effectiveness of these treatments. A total of 360 nicotine dependent individuals who are applying for smoking cessation treatment will be stratified by number of cigarettes smoked, past treatment failure using nicotine replacement therapy versus not, and on history of depression versus not, and randondy assigned from the stratified blocks to receive one of the four treatment conditions. A complete instrument battery will be done at baseline (Week 0); further assessments will be completed at brief treatment termination (Week 12), 6 months (Week 24), 9 months (Week 36), and one year (Week 52). Variables assessed are smoking behavior and biochemically verified smoking status, diagnosis, demographics and treatment history, state and trait measures of mood, support for quitting smoking, cigarette craving, and medication side effects. The cost effectiveness of the treatment conditions will be determined. If funded, this study will provide data about the efficacy and the cost effectiveness of treatments for smoking cessation based on rigorously designed clinical experiments. These data have implications for treatment providers and policy makers.


Alcohol and marijuana use in the context of tobacco dependence treatment: impact on outcome and mediation of effect.
Authors: Hendricks P.S. , Delucchi K.L. , Humfleet G.L. , Hall S.M. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012 Aug; 14(8), p. 942-51.
EPub date: 2012-01-17.
PMID: 22259148
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Longitudinal analysis of abstinence-specific social support and smoking cessation.
Authors: Lawhon D. , Humfleet G.L. , Hall S.M. , Muñoz R.F. , Reus V.I. .
Source: Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2009 Jul; 28(4), p. 465-72.
PMID: 19594271
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Therapeutic drug monitoring of nortriptyline in smoking cessation: a multistudy analysis.
Authors: Mooney M.E. , Reus V.I. , Gorecki J. , Hall S.M. , Humfleet G.L. , Muñoz R.F. , Delucchi K. .
Source: Clinical pharmacology and therapeutics, 2008 Mar; 83(3), p. 436-42.
EPub date: 2007-08-08.
PMID: 17687275
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Cost-effectiveness of bupropion, nortriptyline, and psychological intervention in smoking cessation.
Authors: Hall S.M. , Lightwood J.M. , Humfleet G.L. , Bostrom A. , Reus V.I. , Muñoz R. .
Source: The journal of behavioral health services & research, 2005 Oct-Dec; 32(4), p. 381-92.
PMID: 16215448
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Preliminary evidence of the association between the history of childhood attention-deficit/hyperactivity disorder and smoking treatment failure.
Authors: Humfleet G.L. , Prochaska J.J. , Mengis M. , Cullen J. , Muñoz R. , Reus V. , Hall S.M. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2005 Jun; 7(3), p. 453-60.
PMID: 16085513
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The construct of internalization: conceptualization, measurement, and prediction of smoking treatment outcome.
Authors: Acton G.S. , Kunz J.D. , Wilson M. , Hall S.M. .
Source: Psychological medicine, 2005 Mar; 35(3), p. 395-408.
PMID: 15841875
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Depressed smokers and stage of change: implications for treatment interventions.
Authors: Prochaska J.J. , Rossi J.S. , Redding C.A. , Rosen A.B. , Tsoh J.Y. , Humfleet G.L. , Eisendrath S.J. , Meisner M.R. , Hall S.M. .
Source: Drug and alcohol dependence, 2004-11-11; 76(2), p. 143-51.
PMID: 15488338
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Measurement of impulsivity in a hierarchical model of personality traits: implications for substance use.
Authors: Acton G.S. .
Source: Substance use & misuse, 2003 Jan; 38(1), p. 67-83.
PMID: 12602807
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Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy.
Authors: Jacob P. , Hatsukami D. , Severson H. , Hall S. , Yu L. , Benowitz N.L. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002 Dec; 11(12), p. 1668-73.
PMID: 12496059
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Psychological intervention and antidepressant treatment in smoking cessation.
Authors: Hall S.M. , Humfleet G.L. , Reus V.I. , Muñoz R.F. , Hartz D.T. , Maude-Griffin R. .
Source: Archives of general psychiatry, 2002 Oct; 59(10), p. 930-6.
PMID: 12365880
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Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation.
Authors: Xu B. , Kim S.T. , Lim D.S. , Kastan M.B. .
Source: Molecular and cellular biology, 2002 Feb; 22(4), p. 1049-59.
PMID: 11809797
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Depression and stages of change for smoking in psychiatric outpatients.
Authors: Acton G.S. , Prochaska J.J. , Kaplan A.S. , Small T. , Hall S.M. .
Source: Addictive behaviors, 2001 Sep-Oct; 26(5), p. 621-31.
PMID: 11676374
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Statistical analysis of randomized trials in tobacco treatment: longitudinal designs with dichotomous outcome.
Authors: Hall S.M. , Delucchi K.L. , Velicer W.F. , Kahler C.W. , Ranger-Moore J. , Hedeker D. , Tsoh J.Y. , Niaura R. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2001 Aug; 3(3), p. 193-202.
PMID: 11506764
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Psychological interventions: state of the art.
Authors: Hall S.M. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 1999; 1 Suppl 2, p. S169-73; discussion S207-10.
PMID: 11768176
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