DESCRIPTION: (Adapted from the Applicant's Abstract): The proposed
research is a systematic examination of cancer risk in relation to family
history of cancer in a large population-based genealogy. It is clear from
numerous epidemiologic and genetic studies that a family history of many
kinds of cancer increases a person's risk of cancer, and in several cases
mutations of particular genes have been identified that are associated with
familial cancer syndromes. However, for the vast majority of cancers, the
specific contributions of inherited predisposition to cancer risk have not
been well described. We propose to examine cancer risk associated with
family histories of cancer in a large cohort of people identified through
the Utah Population Database (UPDB), a resource that contains pedigree
information up to six generations deep on over one million individuals. The
genealogy records are linked on a continuing basis to the records of the
Utah Cancer Registry, which has recorded all cancers diagnosed in Utah since
1966. We will examine alternative methods for estimating familial
aggregation of cancer, estimate relative and attributable risks associated
with family history for 36 different kinds of cancer, and examine the
patterns of familial coaggregation of cancer. In order to accomplish these
goals, we will incorporate new follow-up information into UPDB that we will
make available to all users of the database.
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