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Grant Details

Grant Number: 5R29CA069421-05 Interpret this number
Primary Investigator: Kerber, Richard
Organization: University Of Utah
Project Title: Familial Aggregation and Coaggregation of Cancer
Fiscal Year: 2000


Abstract

DESCRIPTION: (Adapted from the Applicant's Abstract): The proposed research is a systematic examination of cancer risk in relation to family history of cancer in a large population-based genealogy. It is clear from numerous epidemiologic and genetic studies that a family history of many kinds of cancer increases a person's risk of cancer, and in several cases mutations of particular genes have been identified that are associated with familial cancer syndromes. However, for the vast majority of cancers, the specific contributions of inherited predisposition to cancer risk have not been well described. We propose to examine cancer risk associated with family histories of cancer in a large cohort of people identified through the Utah Population Database (UPDB), a resource that contains pedigree information up to six generations deep on over one million individuals. The genealogy records are linked on a continuing basis to the records of the Utah Cancer Registry, which has recorded all cancers diagnosed in Utah since 1966. We will examine alternative methods for estimating familial aggregation of cancer, estimate relative and attributable risks associated with family history for 36 different kinds of cancer, and examine the patterns of familial coaggregation of cancer. In order to accomplish these goals, we will incorporate new follow-up information into UPDB that we will make available to all users of the database.



Publications

A cohort study of cancer risk in relation to family histories of cancer in the Utah population database.
Authors: Kerber R.A. , O'Brien E. .
Source: Cancer, 2005-05-01; 103(9), p. 1906-15.
PMID: 15779016
Related Citations

Association between telomere length in blood and mortality in people aged 60 years or older.
Authors: Cawthon R.M. , Smith K.R. , O'Brien E. , Sivatchenko A. , Kerber R.A. .
Source: Lancet (London, England), 2003-02-01; 361(9355), p. 393-5.
PMID: 12573379
Related Citations

Telomere measurement by quantitative PCR.
Authors: Cawthon R.M. .
Source: Nucleic acids research, 2002-05-15; 30(10), p. e47.
PMID: 12000852
Related Citations

Familial excess longevity in Utah genealogies.
Authors: Kerber R.A. , O'Brien E. , Smith K.R. , Cawthon R.M. .
Source: The journals of gerontology. Series A, Biological sciences and medical sciences, 2001 Mar; 56(3), p. B130-9.
PMID: 11253150
Related Citations

Measures of familial aggregation as predictors of breast-cancer risk.
Authors: Boucher K.M. , Kerber R.A. .
Source: Journal of epidemiology and biostatistics, 2001; 6(5), p. 377-85.
PMID: 11822727
Related Citations

Risk of colon cancer associated with a family history of cancer or colorectal polyps: the diet, activity, and reproduction in colon cancer study.
Authors: Kerber R.A. , Slattery M.L. , Potter J.D. , Caan B.J. , Edwards S.L. .
Source: International journal of cancer, 1998-10-05; 78(2), p. 157-60.
PMID: 9754645
Related Citations

Comparison of self-reported and database-linked family history of cancer data in a case-control study.
Authors: Kerber R.A. , Slattery M.L. .
Source: American journal of epidemiology, 1997-08-01; 146(3), p. 244-8.
PMID: 9247008
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