Grant Number:	5R01CA077082-04 Interpret this number
Primary Investigator:	Brown, Richard
Organization:	Butler Hospital (Providence, Ri)
Project Title:	Smoking Cessation in Teens with Comorbid Psychopathology
Fiscal Year:	2000

DESCRIPTION: (Applicant's Description) Adolescent cigarette smokers have disproportionately high rates of co-occurring psychiatric and substance use disorders, similar to those found in the adult smoking population. In the absence of intervention, adolescent smokers with comorbid psychopathology are likely to become highly dependent, recalcitrant adult smokers who have extreme difficulty quitting smoking. The overall objective of this research program is to develop effective smoking cessation approaches for these high risk youth, and to advance the applicant's knowledge of the relationship between psychopathology and smoking cessation within the context of a treatment outcome study. The proposed study will test the comparative efficacy of a maximal, tailored and sustained social learning--based smoking cessation treatment versus a minimal smoking cessation treatment in adolescent cigarette smokers with comorbid psychopathology. The applicants will also test the effects of treatment on intermediate variables and examine individual difference variables as predictors of treatment outcome. The study is a randomized (by cohort), two-group design with repeated measures over time, comparing the efficacy of: (1) brief advice and self-help materials (BA), or (2) a tailored and sustained, motivational intervention with personalized feedback, relapse prevention and coping skills/mood management training, continued telephone counseling, and a parent-involvement phone intervention (MI+). In both conditions, adolescent smokers with clear evidence of nicotine dependence and desire to quit smoking will be offered transdermal nicotine patch (TNP) therapy upon hospital discharge; for MI+ subjects, the offer of TNP therapy will extend throughout the 6 months post-hospital discharge period. A sample of 320 regular weekly smokers between the ages of 13 and 17 will be recruited into the study. Subjects will be followed for one year, and smoking cessation will be verified by carbon monoxide and saliva cotinine. The applicants expect that this study will result in the development of a specialized, efficacious treatment intervention approach for the large percentage of adolescent smokers with comorbid psychiatric and substance use disorders, and will therefore have important clinical and public health significance.




Adaptation of a sustained care cessation intervention for smokers hospitalized for psychiatric disorders: Study protocol for a randomized controlled trial.
Authors: Hecht J. , Rigotti N.A. , Minami H. , Kjome K.L. , Bloom E.L. , Kahler C.W. , Price L.H. , Levy D.E. , Carpenter K.M. , Brown R.A. .
Source: Contemporary clinical trials, 2019 Aug; 83, p. 18-26.
EPub date: 2019-06-15.
PMID: 31212100
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Quit intention as a predictor of quit attempts over time in adolescents with psychiatric disorders.
Authors: Tzilos G.K. , Strong D.R. , Abrantes A.M. , Ramsey S.E. , Brown R.A. .
Source: The American journal on addictions, 2014 Jan-Feb; 23(1), p. 84-89.
EPub date: 2013-06-26.
PMID: 23898867
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Gender Differences in the Relationship Between Physical Activity and Smoking Among Psychiatrically Hospitalized Adolescents.
Authors: Bloom E.L. , Abrantes A.M. , Fokas K.F. , Ramsey S.E. , Brown R.A. .
Source: Mental health and physical activity, 2012-12-01; 5(2), p. 136-140.
EPub date: 2012-11-02.
PMID: 23459125
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Adolescent first lapse following smoking cessation: situation characteristics, precipitants and proximal influences.
Authors: Myers M.G. , Gwaltney C.J. , Strong D.R. , Ramsey S.E. , Brown R.A. , Monti P.M. , Colby S.M. .
Source: Addictive behaviors, 2011 Dec; 36(12), p. 1253-60.
EPub date: 2011-08-05.
PMID: 21903332
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Effects on substance use outcomes in adolescents receiving motivational interviewing for smoking cessation during psychiatric hospitalization.
Authors: Brown R.A. , Strong D.R. , Abrantes A.M. , Myers M.G. , Ramsey S.E. , Kahler C.W. .
Source: Addictive behaviors, 2009 Oct; 34(10), p. 887-91.
EPub date: 2009-03-11.
PMID: 19342179
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Association of post-treatment smoking change with future smoking and cessation efforts among adolescents with psychiatric comorbidity.
Authors: MacPherson L. , Strong D.R. , Kahler C.W. , Abrantes A.M. , Ramsey S.E. , Brown R.A. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2007 Dec; 9(12), p. 1297-307.
PMID: 18058348
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Readiness to change smoking behavior in adolescents with psychiatric disorders.
Authors: Apodaca T.R. , Abrantes A.M. , Strong D.R. , Ramsey S.E. , Brown R.A. .
Source: Addictive behaviors, 2007 Jun; 32(6), p. 1119-30.
EPub date: 2006-09-01.
PMID: 16950572
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Nicotine dependence symptoms among adolescents with psychiatric disorders: using a Rasch model to evaluate symptom expression across time.
Authors: Strong D.R. , Kahler C.W. , Abrantes A.M. , MacPherson L. , Myers M.G. , Ramsey S.E. , Brown R.A. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2007 May; 9(5), p. 557-69.
PMID: 17454712
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HIV-RISK BEHAVIORS AMONG PSYCHIATRICALLY HOSPITALIZED ADOLESCENTS WITH AND WITHOUT COMORBID SUD.
Authors: Abrantes A.M. , Strong D.R. , Ramsey S.E. , Kazura A.N. , Brown R.A. .
Source: Journal of dual diagnosis, 2006-07-24; 2(3), p. 85-100.
PMID: 17410281
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Family and peer influences on tobacco use among adolescents with psychiatric disorders.
Authors: Picotte D.M. , Strong D.R. , Abrantes A.M. , Tarnoff G. , Ramsey S.E. , Kazura A.N. , Brown R.A. .
Source: The Journal of nervous and mental disease, 2006 Jul; 194(7), p. 518-23.
PMID: 16840848
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Substance use disorder characteristics and externalizing problems among inpatient adolescent smokers.
Authors: Abrantes A.M. , Strong D.R. , Ramsey S.E. , Lewinsohn P.M. , Brown R.A. .
Source: Journal of psychoactive drugs, 2005 Dec; 37(4), p. 391-9.
PMID: 16480166
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Nicotine withdrawal among adolescents with acute psychopathology: an item response analysis.
Authors: Strong D.R. , Kahler C.W. , Ramsey S.E. , Abrantes A. , Brown R.A. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2004 Jun; 6(3), p. 547-57.
PMID: 15203788
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Effects of motivational interviewing on smoking cessation in adolescents with psychiatric disorders.
Authors: Brown R.A. , Ramsey S.E. , Strong D.R. , Myers M.G. , Kahler C.W. , Lejuez C.W. , Niaura R. , Pallonen U.E. , Kazura A.N. , Goldstein M.G. , et al. .
Source: Tobacco control, 2003 Dec; 12 Suppl 4(Suppl 4), p. IV3-10.
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Substance use and diagnostic characteristics that differentiate smoking and nonsmoking adolescents in a psychiatric setting.
Authors: Ramsey S.E. , Strong D.R. , Stuart G.L. , Weinstock M.C. , Williams L.A. , Tarnoff G. , Picotte-Prillmayer D.M. , Brown R.A. .
Source: The Journal of nervous and mental disease, 2003 Nov; 191(11), p. 759-62.
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Nicotine dependence measures among adolescents with psychiatric disorders: evaluating symptom expression as a function of dependence severity.
Authors: Strong D.R. , Brown R.A. , Ramsey S.E. , Myers M.G. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2003 Oct; 5(5), p. 735-46.
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Cigarette smoking among adolescent psychiatric inpatients: prevalence and correlates.
Authors: Ramsey S.E. , Brown R.A. , Strong D.R. , Sales S.D. .
Source: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2002 Sep; 14(3), p. 149-53.
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Level of current and past adolescent cigarette smoking as predictors of future substance use disorders in young adulthood.
Authors: Lewinsohn P.M. , Rohde P. , Brown R.A. .
Source: Addiction (Abingdon, England), 1999 Jun; 94(6), p. 913-21.
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