Grant Number:	5R01CA077067-04 Interpret this number
Primary Investigator:	Difranza, Joseph
Organization:	Univ Of Massachusetts Med Sch Worcester
Project Title:	Prospective Study of the Onset of Nicotine Dependence
Fiscal Year:	2000

DESCRIPTION: (Applicant's Description) Little is known about the process by which nicotine dependence develops among adolescent tobacco users. This project will follow a cohort of 650 7th grade students over a period of three and one half years. These subjects will be interviewed every four months during this period about their experiences with tobacco. The tobacco use of these subjects will be monitored in detail with specific attention to the duration of use, the frequency of use and the amount of tobacco consumed. Subjects will be monitored for the development of symptoms of nicotine dependence. The following specific hypotheses will be addressed: 1) Symptoms of nicotine dependence can appear within two months of the first use of tobacco. 2) Symptoms of nicotine dependence can be present when consumption averages less than one cigarette per day. 3) Youths can develop symptoms of nicotine dependence prior to the onset of the daily use of tobacco. 4) The inability to refrain from smoking where it is prohibited will not be an early symptom of dependence.




Short term patterns of early smoking acquisition.
Authors: Wellman R.J. , DiFranza J.R. , Savageau J.A. , Dussault G.F. .
Source: Tobacco Control, 2004 Sep; 13(3), p. 251-7.
PMID: 15333880
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Recollections and repercussions of the first inhaled cigarette.
Authors: DiFranza J.R. , Savageau J.A. , Fletcher K. , Ockene J.K. , Rigotti N.A. , McNeill A.D. , Coleman M. , Wood C. .
Source: Addictive Behaviors, 2004 Feb; 29(2), p. 261-72.
PMID: 14732415
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Symptoms of nicotine dependence and other predictors of student smoking at school: implications for school smoking policy.
Authors: Soteriades E.S. , DiFranza J.R. , Savageau J.A. , Nicolaou M. .
Source: The Journal Of School Health, 2003 Apr; 73(4), p. 154-8.
PMID: 12728614
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Development of symptoms of tobacco dependence in youths: 30 month follow up data from the DANDY study.
Authors: DiFranza J.R. , Savageau J.A. , Rigotti N.A. , Fletcher K. , Ockene J.K. , McNeill A.D. , Coleman M. , Wood C. .
Source: Tobacco Control, 2002 Sep; 11(3), p. 228-35.
PMID: 12198274
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Measuring the loss of autonomy over nicotine use in adolescents: the DANDY (Development and Assessment of Nicotine Dependence in Youths) study.
Authors: DiFranza J.R. , Savageau J.A. , Fletcher K. , Ockene J.K. , Rigotti N.A. , McNeill A.D. , Coleman M. , Wood C. .
Source: Archives Of Pediatrics & Adolescent Medicine, 2002 Apr; 156(4), p. 397-403.
PMID: 11929376
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Initial symptoms of nicotine dependence in adolescents.
Authors: DiFranza J.R. , Rigotti N.A. , McNeill A.D. , Ockene J.K. , Savageau J.A. , St Cyr D. , Coleman M. .
Source: Tobacco Control, 2000 Sep; 9(3), p. 313-9.
PMID: 10982576
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