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Grant Details

Grant Number: 5R01CA074877-04 Interpret this number
Primary Investigator: Horn-Ross, Pamela
Organization: Cancer Prevention Instit Of California
Project Title: Phytoestrogens, Physical Activity and Endometrial Cancer
Fiscal Year: 2000


DESCRIPTION: This population-based epidemiologic study will examine the role that nutritionally-related factors play in the development of endometrial cancer. Special emphasis will be placed on phytoestrogens (i.e., weak estrogens, derived from plant foods, that may have antiestrogenic effects) and physical activity. Little is known about how these factors affect endometrial cancer risk and both offer potential avenues for prevention. Additionally, there are plans to determine whether the effects of obesity, a strong risk factor for endometrial cancer, can be modified by high levels of phytoestrogen consumption. Building on research currently being conducted, there are plans to examine the effects of seven specific phytoestrogenic compounds. The proposed case-control study will be conducted in the San Francisco Bay Area, an ethnically and culturally heterogeneous population, providing substantial variation in dietary intake, including phytoestrogen consumption, and physical activity. White, African American and Latina women, aged 35-79, diagnosed with endometrial cancer during a three-year period, will be identified. These cases will be frequency-matched to controls, based on ethnicity and five-year age group. Controls will be identified from control women, participating in an ongoing, population-based, case-control study of breast cancer, which addresses analogous hypotheses. The questionnaire being used in that study, which was developed specifically to address these areas (including a comprehensive assessment of diet and lifetime occupational and leisure time physical activity), will be used in the proposed study. In-person interviews will be conducted in English or Spanish and anthropometric measurements taken. After initial examination of the data, analyses will be conducted, using unconditional logistic regression, adjusting for age, ethnicity and potential confounders. By combining this research with the ongoing breast cancer study, the proposed study will provide important information on endometrial cancer aetiology and the relationship between breast and endometrial cancer aetiology in terms of these modifiable, nutritionally-related factors.


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Risk factors for endometrial cancer in black and white women: a pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2).
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Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium.
Authors: Setiawan V.W. , Pike M.C. , Karageorgi S. , Deming S.L. , Anderson K. , Bernstein L. , Brinton L.A. , Cai H. , Cerhan J.R. , Cozen W. , et al. .
Source: American journal of epidemiology, 2012-08-15; 176(4), p. 269-78.
EPub date: 2012-07-23.
PMID: 22831825
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Lifetime physical activity and risk of endometrial cancer.
Authors: John E.M. , Koo J. , Horn-Ross P.L. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010 May; 19(5), p. 1276-83.
EPub date: 2010-04-20.
PMID: 20406960
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Maximizing resources to study an uncommon cancer: E2C2--Epidemiology of Endometrial Cancer Consortium.
Authors: Olson S.H. , Chen C. , De Vivo I. , Doherty J.A. , Hartmuller V. , Horn-Ross P.L. , Lacey J.V. , Lynch S.M. , Sansbury L. , Setiawan V.W. , et al. .
Source: Cancer causes & control : CCC, 2009 May; 20(4), p. 491-6.
EPub date: 2009-01-09.
PMID: 19132539
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Dietary patterns, Mediterranean diet, and endometrial cancer risk.
Authors: Dalvi T.B. , Canchola A.J. , Horn-Ross P.L. .
Source: Cancer causes & control : CCC, 2007 Nov; 18(9), p. 957-66.
EPub date: 2007-07-19.
PMID: 17638105
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Phytoestrogen intake and endometrial cancer risk.
Authors: Horn-Ross P.L. , John E.M. , Canchola A.J. , Stewart S.L. , Lee M.M. .
Source: Journal of the National Cancer Institute, 2003-08-06; 95(15), p. 1158-64.
PMID: 12902445
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