DESCRIPTION: (Adapted from the Applicant's Abstract): The authors propose
to collect pedigree information, epidemiologic data and biologic specimens
from a multiethnic, population-based series of patients with epithelial
ovarian cancer and their female relatives, and store the data in a Family
Registry for Ovarian Cancer (FROC). They will collect the data from the
large, multiethnic population in a six county region in Northern California
covered by the Greater Bay Area Cancer Registry (GBACR). Specific aims
include: 1) compare family-history-positive (FHP) and
family-history-negative (FHN) ovarian cancer patients with respect to
ethnicity, invasiveness and histologic type of tumor, and age at diagnosis;
2) evaluate the prevalence of BRCA1 mutations in all FHP and a sample of FHN
probands. Use the results to: a) look for correlations between type-site
of mutation and ethnicity, invasiveness and histology of tumor, and the
spectrum of cancers in the family; and b) validate algorithms for using
demographic and epidemiologic attributes and family history to assign a
woman a probability of carrying a mutation. Such algorithms are essential
for deciding who will be eligible for expensive BRCA1 testing; 3) perform
segregation analyses on the pedigree and epidemiologic data (with and
without BRCA1 families); 4) identify in probands a representative population
of ovarian cancer patients and in their unaffected relatives a
representative population of women at high risk for ovarian cancer that
could be a) followed for survival and subsequent cancer incidence in
relation to ethnicity, family history and BRCA1 mutations, and b) used in
candidate gene association studies. The goal is to provide a registry
resource for interdisciplinary etiologic and translational research on
ovarian cancer. This proposal complements a similar one from the Fred
Hutchison Cancer Center, providing the investigators an opportunity to
analyze the combined population-based data from Northern California and
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