Grant Number:	5R01CA074517-05 Interpret this number
Primary Investigator:	Wetter, David
Organization:	Group Health Cooperative
Project Title:	Individualized Relapse Prevention Among Women Smokers
Fiscal Year:	2000

Among women, the epidemic of smoking related cancers continues to grow and lung cancer recently surpassed breast cancer as the leading cause of cancer mortality. Smoking cessation is a cornerstone of cancer prevention and control because cancer risk declines following smoking cessation. Unfortunately, relapse is the "rule rather than the exception" among smokers attempting to quit and relapse remains the most refractory aspect of nicotine dependence. Women appear to have higher relapse rates than men and relapse prevention has been identified as a priority in reducing smoking prevalence among women. Basic and clinical research on the precipitants of smoking relapse have demonstrated that coping behaviors are powerful determinants of relapse. The most influential model of smoking relapse, "relapse prevention" (Marlatt & Gordon, 1985), proposes that self-efficacy and outcome expectations are causal determinants of coping behaviors, and in fact, these variables have been among the better predictors of relapse. Moreover, there is evidence that interventions based on relapse prevention theory are effective, that they instill coping skills, and that coping skill acquisition mediates intervention effects on abstinence. The specific aims of this proposal are to: l) Develop and evaluate the efficacy of a unique, self-help smoking relapse revention intervention among women. The intervention will be administered via a small hand-held computer. The general ontent of the intervention will be tailored specifically for women and each participant's intervention will be individualized prior to delivery based on state-of-the-art "ecological momentary assessment" techniques; and, 2) Examine the effects of the relapse prevention intervention on hypothesized treatment mechanisms (coping behaviors, self-efficacy, processes of change, negative affect, perceived stress) and the impact of those mechanisms on relapse, i.e. test for mediation effects. The proposal translates basic and clinical behavioral science research into a novel, theoretically-based treatment that provides individualized, situation-specific coping strategies, motivational and supportive messages, and other relapse prevention information. Moreover, unlike conventional relapse prevention treatments, participants have access to the intervention at an time and in any place, i.e. the intervention occurs in real-time in naturally occurring settings. The intervention has the potential to produce significant advances in the prevention of smoking relapse.




Positive smoking outcome expectancies mediate the association between negative affect and smoking urge among women during a quit attempt.
Authors: Cano M.Á. , Lam C.Y. , Chen M. , Adams C.E. , Correa-Fernández V. , Stewart D.W. , McClure J.B. , Cinciripini P.M. , Wetter D.W. .
Source: Experimental And Clinical Psychopharmacology, 2014 Aug; 22(4), p. 332-40.
PMID: 24796849
Related Citations

Individual and combined effects of multiple high-risk triggers on postcessation smoking urge and lapse.
Authors: Lam C.Y. , Businelle M.S. , Aigner C.J. , McClure J.B. , Cofta-Woerpel L. , Cinciripini P.M. , Wetter D.W. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2014 May; 16(5), p. 569-75.
PMID: 24323569
Related Citations

Positive smoking outcome expectancies mediate the relation between alcohol consumption and smoking urge among women during a quit attempt.
Authors: Lam C.Y. , Businelle M.S. , Cofta-Woerpel L. , McClure J.B. , Cinciripini P.M. , Wetter D.W. .
Source: Psychology Of Addictive Behaviors : Journal Of The Society Of Psychologists In Addictive Behaviors, 2014 Mar; 28(1), p. 163-72.
PMID: 24731113
Related Citations

Alcohol consumption and urges to smoke among women during a smoking cessation attempt.
Authors: Businelle M.S. , Lam C.Y. , Kendzor D.E. , Cofta-Woerpel L. , McClure J.B. , Cinciripini P.M. , Wetter D.W. .
Source: Experimental And Clinical Psychopharmacology, 2013 Feb; 21(1), p. 29-37.
PMID: 23379613
Related Citations

Early cessation success or failure among women attempting to quit smoking: trajectories and volatility of urge and negative mood during the first postcessation week.
Authors: Cofta-Woerpel L. , McClure J.B. , Li Y. , Urbauer D. , Cinciripini P.M. , Wetter D.W. .
Source: Journal Of Abnormal Psychology, 2011 Aug; 120(3), p. 596-606.
PMID: 21574667
Related Citations

A randomized clinical trial of a palmtop computer-delivered treatment for smoking relapse prevention among women.
Authors: Wetter D.W. , McClure J.B. , Cofta-Woerpel L. , Costello T.J. , Reitzel L.R. , Businelle M.S. , Cinciripini P.M. .
Source: Psychology Of Addictive Behaviors : Journal Of The Society Of Psychologists In Addictive Behaviors, 2011 Jun; 25(2), p. 365-71.
PMID: 21500879
Related Citations

Evaluating reactivity to ecological momentary assessment during smoking cessation.
Authors: Rowan P.J. , Cofta-Woerpel L. , Mazas C.A. , Vidrine J.I. , Reitzel L.R. , Cinciripini P.M. , Wetter D.W. .
Source: Experimental And Clinical Psychopharmacology, 2007 Aug; 15(4), p. 382-9.
PMID: 17696685
Related Citations

Late relapse/sustained abstinence among former smokers: a longitudinal study.
Authors: Wetter D.W. , Cofta-Gunn L. , Fouladi R.T. , Cinciripini P.M. , Sui D. , Gritz E.R. .
Source: Preventive Medicine, 2004 Dec; 39(6), p. 1156-63.
PMID: 15539050
Related Citations

The effects of depressed mood on smoking cessation: mediation by postcessation self-efficacy.
Authors: Cinciripini P.M. , Wetter D.W. , Fouladi R.T. , Blalock J.A. , Carter B.L. , Cinciripini L.G. , Baile W.F. .
Source: Journal Of Consulting And Clinical Psychology, 2003 Apr; 71(2), p. 292-301.
PMID: 12699023
Related Citations

Relations between self-generated positive and negative expected smoking outcomes and smoking behavior: an exploratory study among adolescents.
Authors: Anderson C.B. , Pollak K.I. , Wetter D.W. .
Source: Psychology Of Addictive Behaviors : Journal Of The Society Of Psychologists In Addictive Behaviors, 2002 Sep; 16(3), p. 196-204.
PMID: 12236454
Related Citations