Grant Details
Grant Number: |
5R01CA055488-09 Interpret this number |
Primary Investigator: |
Kiviat, Nancy |
Organization: |
University Of Washington |
Project Title: |
Epidemiology of Anal HIV-1 Infection |
Fiscal Year: |
2000 |
Abstract
We are in the fourth and final year of a study of the relationship between
human immunodeficiency virus (HIV), and types of human papillomavirus
(HPV), immunosuppression, and risk of development of high grade anal
squamous intraepithelial lesions (HGASIL), the anal cancer precursor
lesion most closely related to invasive anal cancer (R01CA55488, Nancy
Kiviat PI). Our major findings included: a) development of high grade
anal squamous intraepithelial lesions (HGASIL) is associated with HIV
seropositivity, with HIV seropositive men with CD4 count below 500/mul at
greatest risk; b) among both HIV seropositive and HIV seronegative men,
development of HGASIL associated with high levels of HPV types 16/18; (c)
development of HGASIL is associated with low risk HPV type HPV in addition
to HPV 16/18 among HIV seropositive, but not among seronegative men; and
d) HIV seronegative were much more likely to regress from HGASIL to normal
than were HIV seropositive men. We now propose a survey of questions
focused on further exploring the relationship between HIV and HPV. We
will: 1) test the hypothesis that the development of ASIL is associated
with the presence and amount of HIV; 2) determine whether there is support
of the hypothesis that the effect of anal HIV on anal HPV is (a) the
result of local HIV induced immunosuppression (b) direct effect of HIV on
HPV; and 3) initiate studies examining the characteristics, pathogenesis
and clinical consequences of anal HIV variants: by cross sectional
analysis of first visit samples. In summary, we propose a survey of
questions that are likely to contribute significantly to our understanding
of both general HIV pathogenesis and the development of HPV-related
pathology among HIV-seropositive men.
Publications
Hiv-1 Superinfection In The Antiretroviral Therapy Era: Are Seroconcordant Sexual Partners At Risk?
Authors: Campbell M.S.
, Gottlieb G.S.
, Hawes S.E.
, Nickle D.C.
, Wong K.G.
, Deng W.
, Lampinen T.M.
, Kiviat N.B.
, Mullins J.I.
.
Source: Plos One, 2009; 4(5), p. e5690.
PMID: 19479055
Related Citations
Hiv Infection And Human Herpesvirus-8 Oral Shedding Among Men Who Have Sex With Men
Authors: Casper C.
, Redman M.
, Huang M.L.
, Pauk J.
, Lampinen T.M.
, Hawes S.E.
, Critchlow C.W.
, Morrow R.A.
, Corey L.
, Kiviat N.
, et al.
.
Source: Journal Of Acquired Immune Deficiency Syndromes (1999), 2004-03-01 00:00:00.0; 35(3), p. 233-8.
PMID: 15076237
Related Citations
The intensity-score approach to adjusting for confounding.
Authors: Brumback B.
, Greenland S.
, Redman M.
, Kiviat N.
, Diehr P.
.
Source: Biometrics, 2003 Jun; 59(2), p. 274-85.
PMID: 12926712
Related Citations
Detection Of Cervical Antibodies To Human Papillomavirus Type 16 (hpv-16) Capsid Antigens In Relation To Detection Of Hpv-16 Dna And Cervical Lesions
Authors: Hagensee M.E.
, Koutsky L.A.
, Lee S.K.
, Grubert T.
, Kuypers J.
, Kiviat N.B.
, Galloway D.A.
.
Source: The Journal Of Infectious Diseases, 2000 Apr; 181(4), p. 1234-9.
PMID: 10753726
Related Citations
Association Of Antiretroviral Therapy With Detection Of Hiv-1 Rna And Dna In The Anorectal Mucosa Of Homosexual Men
Authors: Lampinen T.M.
, Critchlow C.W.
, Kuypers J.M.
, Hurt C.S.
, Nelson P.J.
, Hawes S.E.
, Coombs R.W.
, Holmes K.K.
, Kiviat N.B.
.
Source: Aids (london, England), 2000-03-31 00:00:00.0; 14(5), p. F69-75.
PMID: 10780708
Related Citations
Comparison Of Variant-specific Hybridization And Single-strand Conformational Polymorphism Methods For Detection Of Mixed Human Papillomavirus Type 16 Variant Infections
Authors: Emeny R.T.
, Herron J.R.
, Xi L.F.
, Koutsky L.A.
, Kiviat N.B.
, Wheeler C.M.
.
Source: Journal Of Clinical Microbiology, 1999 Nov; 37(11), p. 3627-33.
PMID: 10523565
Related Citations
Risk Of Anal Carcinoma In Situ In Relation To Human Papillomavirus Type 16 Variants
Authors: Xi L.F.
, Critchlow C.W.
, Wheeler C.M.
, Koutsky L.A.
, Galloway D.A.
, Kuypers J.
, Hughes J.P.
, Hawes S.E.
, Surawicz C.
, Goldbaum G.
, et al.
.
Source: Cancer Research, 1998-09-01 00:00:00.0; 58(17), p. 3839-44.
PMID: 9731493
Related Citations
Effect Of Hiv Infection On The Natural History Of Anal Human Papillomavirus Infection
Authors: Critchlow C.W.
, Hawes S.E.
, Kuypers J.M.
, Goldbaum G.M.
, Holmes K.K.
, Surawicz C.M.
, Kiviat N.B.
.
Source: Aids (london, England), 1998-07-09 00:00:00.0; 12(10), p. 1177-84.
PMID: 9677167
Related Citations
Determinants Of Human Immunodeficiency Virus Dna And Rna Shedding In The Anal-rectal Canal Of Homosexual Men
Authors: Kiviat N.B.
, Critchlow C.W.
, Hawes S.E.
, Kuypers J.
, Surawicz C.
, Goldbaum G.
, van Burik J.A.
, Lampinen T.
, Holmes K.K.
.
Source: The Journal Of Infectious Diseases, 1998 Mar; 177(3), p. 571-8.
PMID: 9498434
Related Citations
Hazard Regression With Interval-censored Data
Authors: Kooperberg C.
, Clarkson D.B.
.
Source: Biometrics, 1997 Dec; 53(4), p. 1485-94.
PMID: 9423263
Related Citations
Seroprevalence Of Human Papillomavirus Types 6 And 16 Capsid Antibodies In Homosexual Men
Authors: Hagensee M.E.
, Kiviat N.
, Critchlow C.W.
, Hawes S.E.
, Kuypers J.
, Holte S.
, Galloway D.A.
.
Source: The Journal Of Infectious Diseases, 1997 Sep; 176(3), p. 625-31.
PMID: 9291307
Related Citations
Prospective Study Of High Grade Anal Squamous Intraepithelial Neoplasia In A Cohort Of Homosexual Men: Influence Of Hiv Infection, Immunosuppression And Human Papillomavirus Infection
Authors: Critchlow C.W.
, Surawicz C.M.
, Holmes K.K.
, Kuypers J.
, Daling J.R.
, Hawes S.E.
, Goldbaum G.M.
, Sayer J.
, Hurt C.
, Dunphy C.
.
Source: Aids (london, England), 1995 Nov; 9(11), p. 1255-62.
PMID: 8561979
Related Citations
High Grade Anal Dysplasia In Visually Normal Mucosa In Homosexual Men: Seven Cases
Authors: Surawicz C.M.
, Critchlow C.
, Sayer J.
, Hurt C.
, Hawes S.
, Kirby P.
, Goldbaum G.
, Kiviat N.
.
Source: The American Journal Of Gastroenterology, 1995 Oct; 90(10), p. 1776-8.
PMID: 7572893
Related Citations