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Grant Details

Grant Number: 5R01CA055488-09 Interpret this number
Primary Investigator: Kiviat, Nancy
Organization: University Of Washington
Project Title: Epidemiology of Anal HIV-1 Infection
Fiscal Year: 2000
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Abstract

We are in the fourth and final year of a study of the relationship between human immunodeficiency virus (HIV), and types of human papillomavirus (HPV), immunosuppression, and risk of development of high grade anal squamous intraepithelial lesions (HGASIL), the anal cancer precursor lesion most closely related to invasive anal cancer (R01CA55488, Nancy Kiviat PI). Our major findings included: a) development of high grade anal squamous intraepithelial lesions (HGASIL) is associated with HIV seropositivity, with HIV seropositive men with CD4 count below 500/mul at greatest risk; b) among both HIV seropositive and HIV seronegative men, development of HGASIL associated with high levels of HPV types 16/18; (c) development of HGASIL is associated with low risk HPV type HPV in addition to HPV 16/18 among HIV seropositive, but not among seronegative men; and d) HIV seronegative were much more likely to regress from HGASIL to normal than were HIV seropositive men. We now propose a survey of questions focused on further exploring the relationship between HIV and HPV. We will: 1) test the hypothesis that the development of ASIL is associated with the presence and amount of HIV; 2) determine whether there is support of the hypothesis that the effect of anal HIV on anal HPV is (a) the result of local HIV induced immunosuppression (b) direct effect of HIV on HPV; and 3) initiate studies examining the characteristics, pathogenesis and clinical consequences of anal HIV variants: by cross sectional analysis of first visit samples. In summary, we propose a survey of questions that are likely to contribute significantly to our understanding of both general HIV pathogenesis and the development of HPV-related pathology among HIV-seropositive men.

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Publications

HIV-1 superinfection in the antiretroviral therapy era: are seroconcordant sexual partners at risk?
Authors: Campbell M.S. , Gottlieb G.S. , Hawes S.E. , Nickle D.C. , Wong K.G. , Deng W. , Lampinen T.M. , Kiviat N.B. , Mullins J.I. .
Source: PloS one, 2009-05-28; 4(5), p. e5690.
EPub date: 2009-05-28.
PMID: 19479055
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HIV infection and human herpesvirus-8 oral shedding among men who have sex with men.
Authors: Casper C. , Redman M. , Huang M.L. , Pauk J. , Lampinen T.M. , Hawes S.E. , Critchlow C.W. , Morrow R.A. , Corey L. , Kiviat N. , et al. .
Source: Journal of acquired immune deficiency syndromes (1999), 2004-03-01; 35(3), p. 233-8.
PMID: 15076237
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The intensity-score approach to adjusting for confounding.
Authors: Brumback B. , Greenland S. , Redman M. , Kiviat N. , Diehr P. .
Source: Biometrics, 2003 Jun; 59(2), p. 274-85.
PMID: 12926712
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Detection of cervical antibodies to human papillomavirus type 16 (HPV-16) capsid antigens in relation to detection of HPV-16 DNA and cervical lesions.
Authors: Hagensee M.E. , Koutsky L.A. , Lee S.K. , Grubert T. , Kuypers J. , Kiviat N.B. , Galloway D.A. .
Source: The Journal of infectious diseases, 2000 Apr; 181(4), p. 1234-9.
EPub date: 2000-04-07.
PMID: 10753726
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Association of antiretroviral therapy with detection of HIV-1 RNA and DNA in the anorectal mucosa of homosexual men.
Authors: Lampinen T.M. , Critchlow C.W. , Kuypers J.M. , Hurt C.S. , Nelson P.J. , Hawes S.E. , Coombs R.W. , Holmes K.K. , Kiviat N.B. .
Source: AIDS (London, England), 2000-03-31; 14(5), p. F69-75.
PMID: 10780708
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Comparison of variant-specific hybridization and single-strand conformational polymorphism methods for detection of mixed human papillomavirus type 16 variant infections.
Authors: Emeny R.T. , Herron J.R. , Xi L.F. , Koutsky L.A. , Kiviat N.B. , Wheeler C.M. .
Source: Journal of clinical microbiology, 1999 Nov; 37(11), p. 3627-33.
PMID: 10523565
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Risk of anal carcinoma in situ in relation to human papillomavirus type 16 variants.
Authors: Xi L.F. , Critchlow C.W. , Wheeler C.M. , Koutsky L.A. , Galloway D.A. , Kuypers J. , Hughes J.P. , Hawes S.E. , Surawicz C. , Goldbaum G. , et al. .
Source: Cancer research, 1998-09-01; 58(17), p. 3839-44.
PMID: 9731493
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Effect of HIV infection on the natural history of anal human papillomavirus infection.
Authors: Critchlow C.W. , Hawes S.E. , Kuypers J.M. , Goldbaum G.M. , Holmes K.K. , Surawicz C.M. , Kiviat N.B. .
Source: AIDS (London, England), 1998-07-09; 12(10), p. 1177-84.
PMID: 9677167
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Determinants of human immunodeficiency virus DNA and RNA shedding in the anal-rectal canal of homosexual men.
Authors: Kiviat N.B. , Critchlow C.W. , Hawes S.E. , Kuypers J. , Surawicz C. , Goldbaum G. , van Burik J.A. , Lampinen T. , Holmes K.K. .
Source: The Journal of infectious diseases, 1998 Mar; 177(3), p. 571-8.
PMID: 9498434
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Hazard regression with interval-censored data.
Authors: Kooperberg C. , Clarkson D.B. .
Source: Biometrics, 1997 Dec; 53(4), p. 1485-94.
PMID: 9423263
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Seroprevalence of human papillomavirus types 6 and 16 capsid antibodies in homosexual men.
Authors: Hagensee M.E. , Kiviat N. , Critchlow C.W. , Hawes S.E. , Kuypers J. , Holte S. , Galloway D.A. .
Source: The Journal of infectious diseases, 1997 Sep; 176(3), p. 625-31.
PMID: 9291307
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Prospective study of high grade anal squamous intraepithelial neoplasia in a cohort of homosexual men: influence of HIV infection, immunosuppression and human papillomavirus infection.
Authors: Critchlow C.W. , Surawicz C.M. , Holmes K.K. , Kuypers J. , Daling J.R. , Hawes S.E. , Goldbaum G.M. , Sayer J. , Hurt C. , Dunphy C. .
Source: AIDS (London, England), 1995 Nov; 9(11), p. 1255-62.
PMID: 8561979
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High grade anal dysplasia in visually normal mucosa in homosexual men: seven cases.
Authors: Surawicz C.M. , Critchlow C. , Sayer J. , Hurt C. , Hawes S. , Kirby P. , Goldbaum G. , Kiviat N. .
Source: The American journal of gastroenterology, 1995 Oct; 90(10), p. 1776-8.
PMID: 7572893
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