DESCRIPTION: (Adapted from the Applicant's Abstract): Collaborating
investigators at the University of Hawaii and Southern California have
established a substantial cohort comprised of minorities (African-Americans,
Hispanics, Japanese) and Whites. The cohort of 202,136 individuals has been
characterized by questionnaires regarding detailed dietary histories, past
medical histories and other lifestyle characteristics, and is being followed
for all incident cancer cases utilizing population-based cancer registries
in each location. This cohort is of sufficient size and heterogeneity to
study the relationship between environmental risk factors, as determined
primarily by the questionnaire, and genes that may be important alone or as
sources of potential interaction in determining the risk of sporadic cancers
of the colorectum, prostate, and breast. The proposed design maximizes the
efficiency of the cohort by utilizing a nested case-cohort control design.
A total of 400 cohort-controls will be randomly selected from each
ethnic/sex group and blood will be collected from these cohort controls and
from all incident cases of colorectum, prostate, and breast cancer.
Specifically, this proposal will investigate polymorphisms in candidate
genes (NAT2, GSTM1, CYP1A1, SRD5A2, AR, EDH17B2, CYP17, and ER), that might
alter metabolism of relevant endogenous or exogenous exposures and their
interactions with dietary variables (e.g., saturated fat and fiber intake)
and other exogenous exposures (e.g., hormone replacement therapy) that
affect the risk of these three cancers. In addition to case control
comparisons, the design allows for comparison of the frequency of these
genetic polymorphisms across ethnic groups.
Error Notice
The database may currently be offline for maintenance and should be operational soon. If not, we have been notified of this error and will be reviewing it shortly.
We apologize for the inconvenience.
- The DCCPS Team.
