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Grant Details

Grant Number: 5R35CA049761-13 Interpret this number
Primary Investigator: Friedman, Gary
Organization: Stanford University
Project Title: Cancer Epidemiology in a Large Health Care Plan
Fiscal Year: 2000


Abstract

I propose to continue our work in cancer epidemiology that has developed at the Kaiser Permanente Medical Care Program in the past 1 1/2 decades and has been supported for 4 years by an Outstanding Investigators Grant, as follows: 1. Continue surveillance for possible carcinogenic effects of medicinal drugs in a cohort of 143,574 Kaiser Foundation Health Plan members using additional data resources of the program to test hypotheses. Study newer drugs, as appropriate, using the new region-wide pharmacy data system that is currently being implemented. 2. Continue follow-up of a cohort of over 100,000 persons who received multiphasic health checkups plus research questionnaires on smoking and alcohol use, to study cancer-producing effects of various tobacco products, alcoholic beverages, marijuana and other factors. 3. Continue to conduct nested case-control studies of possible chemopreventive factors in the above multiphasic cohort using a large collection of frozen serum specimens. 4. Continue to conduct studies of the efficacy of screening tests in preventing mortality from cancer. 5. Employ the flexibility afforded by the Outstanding Investigator Grant to study promising new leads concerning cancer etiology and control in the extensive data resources of Kaiser Permanente.



Publications

Short-term chloral hydrate administration and cancer in humans.
Authors: Haselkorn T. , Whittemore A.S. , Udaltsova N. , Friedman G.D. .
Source: Drug Safety : An International Journal Of Medical Toxicology And Drug Experience, 2006; 29(1), p. 67-77.
PMID: 16454535
Related Citations

The risk for malignant primary adult-onset glioma in a large, multiethnic, managed-care cohort: cigarette smoking and other lifestyle behaviors.
Authors: Efird J.T. , Friedman G.D. , Sidney S. , Klatsky A. , Habel L.A. , Udaltsova N.V. , Van den Eeden S. , Nelson L.M. .
Source: Journal Of Neuro-oncology, 2004 May; 68(1), p. 57-69.
PMID: 15174522
Related Citations

C-reactive protein, Helicobacter pylori, Chlamydia pneumoniae, cytomegalovirus and risk for myocardial infarction.
Authors: Witherell H.L. , Smith K.L. , Friedman G.D. , Ley C. , Thom D.H. , Orentreich N. , Vogelman J.H. , Parsonnet J. .
Source: Annals Of Epidemiology, 2003 Mar; 13(3), p. 170-7.
PMID: 12604160
Related Citations

Risk of subsequent cancer following invasive or in situ squamous cell skin cancer.
Authors: Efird J.T. , Friedman G.D. , Habel L. , Tekawa I.S. , Nelson L.M. .
Source: Annals Of Epidemiology, 2002 Oct; 12(7), p. 469-75.
PMID: 12377424
Related Citations

Risk factors for synchronous primary endometrial and ovarian cancers.
Authors: Herrinton L.J. , Voigt L.F. , Weiss N.S. , Beresford S.A. , Wingo P.A. .
Source: Annals Of Epidemiology, 2001 Nov; 11(8), p. 529-33.
PMID: 11709271
Related Citations

Exposure to environmental tobacco smoke: association with personal characteristics and self reported health conditions.
Authors: Iribarren C. , Friedman G.D. , Klatsky A.L. , Eisner M.D. .
Source: Journal Of Epidemiology And Community Health, 2001 Oct; 55(10), p. 721-8.
PMID: 11553655
Related Citations

Cohort study of thyroid cancer in a San Francisco Bay area population.
Authors: Iribarren C. , Haselkorn T. , Tekawa I.S. , Friedman G.D. .
Source: International Journal Of Cancer, 2001-09-01 00:00:00.0; 93(5), p. 745-50.
PMID: 11477590
Related Citations

Concomitant medication use in postmenopausal women using estrogen therapy.
Authors: Small R. , Friedman G.D. , Ettinger B. .
Source: Menopause (new York, N.y.), 2001 Summer; 8(2), p. 120-6.
PMID: 11256872
Related Citations

Histological classification of gastric adenocarcinoma for epidemiological research: concordance between pathologists.
Authors: Shibata A. , Longacre T.A. , Puligandla B. , Parsonnet J. , Habel L.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2001 Jan; 10(1), p. 75-8.
PMID: 11205493
Related Citations

Association of basal cell skin cancers with other cancers (United States).
Authors: Friedman G.D. , Tekawa I.S. .
Source: Cancer Causes & Control : Ccc, 2000 Dec; 11(10), p. 891-7.
PMID: 11142523
Related Citations

Colon cancer screening, lifestyle, and risk of colon cancer.
Authors: Slattery M.L. , Edwards S.L. , Ma K.N. , Friedman G.D. .
Source: Cancer Causes & Control : Ccc, 2000 Jul; 11(6), p. 555-63.
PMID: 10880038
Related Citations

Spousal concordance for cancer incidence: A cohort study.
Authors: Friedman G.D. , Quesenberry C.P. .
Source: Cancer, 1999-12-01 00:00:00.0; 86(11), p. 2413-9.
PMID: 10590385
Related Citations

Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary disease, and cancer in men.
Authors: Iribarren C. , Tekawa I.S. , Sidney S. , Friedman G.D. .
Source: The New England Journal Of Medicine, 1999-06-10 00:00:00.0; 340(23), p. 1773-80.
PMID: 10362820
Related Citations

Barbiturates and lung cancer: a re-evaluation.
Authors: Friedman G.D. , Habel L.A. .
Source: International Journal Of Epidemiology, 1999 Jun; 28(3), p. 375-9.
PMID: 10405836
Related Citations

Cholecystectomy and the risk of colon cancer.
Authors: Todoroki I. , Friedman G.D. , Slattery M.L. , Potter J.D. , Samowitz W. .
Source: The American Journal Of Gastroenterology, 1999 Jan; 94(1), p. 41-6.
PMID: 9934729
Related Citations

Barbiturates, smoking, and bladder cancer risk.
Authors: Habel L.A. , Bull S.A. , Friedman G.D. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1998 Nov; 7(11), p. 1049-50.
PMID: 9829715
Related Citations

Cigarette smoking and risk of non-Hodgkin's lymphoma subtypes.
Authors: Herrinton L.J. , Friedman G.D. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1998 Jan; 7(1), p. 25-8.
PMID: 9456239
Related Citations

Risk for gastric lymphoma in persons with CagA+ and CagA- Helicobacter pylori infection.
Authors: Witherell H.L. , Hansen S. , Jellum E. , Orentreich N. , Vogelman J.H. , Parsonnet J. .
Source: The Journal Of Infectious Diseases, 1997 Dec; 176(6), p. 1641-4.
PMID: 9395383
Related Citations

Marijuana use and cancer incidence (California, United States).
Authors: Sidney S. , Quesenberry C.P. , Friedman G.D. , Tekawa I.S. .
Source: Cancer Causes & Control : Ccc, 1997 Sep; 8(5), p. 722-8.
PMID: 9328194
Related Citations

Marijuana use and mortality.
Authors: Sidney S. , Beck J.E. , Tekawa I.S. , Quesenberry C.P. , Friedman G.D. .
Source: American Journal Of Public Health, 1997 Apr; 87(4), p. 585-90.
PMID: 9146436
Related Citations

Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection.
Authors: Parsonnet J. , Friedman G.D. , Orentreich N. , Vogelman H. .
Source: Gut, 1997 Mar; 40(3), p. 297-301.
PMID: 9135515
Related Citations

Physical activity and colon cancer: a public health perspective.
Authors: Slattery M.L. , Edwards S.L. , Ma K.N. , Friedman G.D. , Potter J.D. .
Source: Annals Of Epidemiology, 1997 Feb; 7(2), p. 137-45.
PMID: 9099401
Related Citations

Tobacco use and colon cancer.
Authors: Slattery M.L. , Potter J.D. , Friedman G.D. , Ma K.N. , Edwards S. .
Source: International Journal Of Cancer, 1997-01-27 00:00:00.0; 70(3), p. 259-64.
PMID: 9033624
Related Citations

Depression, smoking, and lung cancer.
Authors: Friedman G.D. .
Source: American Journal Of Epidemiology, 1996-12-15 00:00:00.0; 144(12), p. 1104-6.
PMID: 8956622
Related Citations

Can hematuria be a predictor as well as a symptom or sign of bladder cancer?
Authors: Friedman G.D. , Carroll P.R. , Cattolica E.V. , Hiatt R.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1996 Dec; 5(12), p. 993-6.
PMID: 8959322
Related Citations

A description of age, sex, and site distributions of colon carcinoma in three geographic areas.
Authors: Slattery M.L. , Friedman G.D. , Potter J.D. , Edwards S. , Caan B.J. , Samowitz W. .
Source: Cancer, 1996-10-15 00:00:00.0; 78(8), p. 1666-70.
PMID: 8859178
Related Citations

The incidence of non-Hodgkin's lymphoma and its histologic subtypes in Asian migrants to the United States and their descendants.
Authors: Herrinton L.J. , Goldoft M. , Schwartz S.M. , Weiss N.S. .
Source: Cancer Causes & Control : Ccc, 1996 Mar; 7(2), p. 224-30.
PMID: 8740735
Related Citations

Reduced mortality associated with long-term postmenopausal estrogen therapy.
Authors: Ettinger B. , Friedman G.D. , Bush T. , Quesenberry C.P. .
Source: Obstetrics And Gynecology, 1996 Jan; 87(1), p. 6-12.
PMID: 8532268
Related Citations

Case-control study of digital-rectal screening in relation to mortality from cancer of the distal rectum.
Authors: Herrinton L.J. , Selby J.V. , Friedman G.D. , Quesenberry C.P. , Weiss N.S. .
Source: American Journal Of Epidemiology, 1995-11-01 00:00:00.0; 142(9), p. 961-4.
PMID: 7572977
Related Citations

Transferrin saturation and risk of cancer.
Authors: Herrinton L.J. , Friedman G.D. , Baer D. , Selby J.V. .
Source: American Journal Of Epidemiology, 1995-10-01 00:00:00.0; 142(7), p. 692-8.
PMID: 7572938
Related Citations

Seasonal variation in vitamin D, vitamin D-binding protein, and dehydroepiandrosterone: risk of prostate cancer in black and white men.
Authors: Corder E.H. , Friedman G.D. , Vogelman J.H. , Orentreich N. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1995 Sep; 4(6), p. 655-9.
PMID: 8547833
Related Citations

Cholecystectomy not confirmed as a risk factor for pancreatic cancer.
Authors: Friedman G.D. .
Source: International Journal Of Cancer, 1995-05-29 00:00:00.0; 61(5), p. 745-6.
PMID: 7768651
Related Citations

Mentholated cigarette use and lung cancer.
Authors: Sidney S. , Tekawa I.S. , Friedman G.D. , Sadler M.C. , Tashkin D.P. .
Source: Archives Of Internal Medicine, 1995-04-10 00:00:00.0; 155(7), p. 727-32.
PMID: 7695461
Related Citations

Prostate-specific antigen as predictor of prostate cancer in black men and white men.
Authors: Whittemore A.S. , Lele C. , Friedman G.D. , Stamey T. , Vogelman J.H. , Orentreich N. .
Source: Journal Of The National Cancer Institute, 1995-03-01 00:00:00.0; 87(5), p. 354-60.
PMID: 7531773
Related Citations

Breast cancer incidence in Asian migrants to the United States and their descendants.
Authors: Stanford J.L. , Herrinton L.J. , Schwartz S.M. , Weiss N.S. .
Source: Epidemiology (cambridge, Mass.), 1995 Mar; 6(2), p. 181-3.
PMID: 7742407
Related Citations

Serum cholesterol concentration and risk of brain cancer.
Authors: Herrinton L.J. , Friedman G.D. .
Source: Bmj (clinical Research Ed.), 1995-02-11 00:00:00.0; 310(6976), p. 367-8.
PMID: 7866214
Related Citations

Problems in assessing screening experience in observational studies of screening efficacy: example of urinalysis screening for bladder cancer.
Authors: Friedman G.D. , Hiatt R.A. , Quesenberry C.P. , Selby J.V. , Weiss N.S. .
Source: Journal Of Medical Screening, 1995; 2(4), p. 219-23.
PMID: 8719152
Related Citations

Ovarian cancer incidence among Asian migrants to the United States and their descendants.
Authors: Herrinton L.J. , Stanford J.L. , Schwartz S.M. , Weiss N.S. .
Source: Journal Of The National Cancer Institute, 1994-09-07 00:00:00.0; 86(17), p. 1336-9.
PMID: 8064892
Related Citations

Obesity and multiple myeloma.
Authors: Friedman G.D. , Herrinton L.J. .
Source: Cancer Causes & Control : Ccc, 1994 Sep; 5(5), p. 479-83.
PMID: 7999970
Related Citations

Opportunities for research in dermatologic epidemiology.
Authors: Friedman G.D. .
Source: The Journal Of Investigative Dermatology, 1994 Jun; 102(6), p. 57S-58S.
PMID: 8006440
Related Citations

Helicobacter pylori infection and gastric lymphoma.
Authors: Parsonnet J. , Hansen S. , Rodriguez L. , Gelb A.B. , Warnke R.A. , Jellum E. , Orentreich N. , Vogelman J.H. , Friedman G.D. .
Source: The New England Journal Of Medicine, 1994-05-05 00:00:00.0; 330(18), p. 1267-71.
PMID: 8145781
Related Citations

Psychiatrically-diagnosed depression and subsequent cancer.
Authors: Friedman G.D. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1994 Jan-Feb; 3(1), p. 11-3.
PMID: 8118378
Related Citations

Helicobacter pylori, pepsinogen, and risk for gastric adenocarcinoma.
Authors: Parsonnet J. , Samloff I.M. , Nelson L.M. , Orentreich N. , Vogelman J.H. , Friedman G.D. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1993 Sep-Oct; 2(5), p. 461-6.
PMID: 8220091
Related Citations

Vitamin D and prostate cancer: a prediagnostic study with stored sera.
Authors: Corder E.H. , Guess H.A. , Hulka B.S. , Friedman G.D. , Sadler M. , Vollmer R.T. , Lobaugh B. , Drezner M.K. , Vogelman J.H. , Orentreich N. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1993 Sep-Oct; 2(5), p. 467-72.
PMID: 8220092
Related Citations

Coffee, tea, and mortality.
Authors: Klatsky A.L. , Armstrong M.A. , Friedman G.D. .
Source: Annals Of Epidemiology, 1993 Jul; 3(4), p. 375-81.
PMID: 8275213
Related Citations

Cigarette smoking, leukemia, and multiple myeloma.
Authors: Friedman G.D. .
Source: Annals Of Epidemiology, 1993 Jul; 3(4), p. 425-8.
PMID: 8275220
Related Citations

Natural history of asymptomatic and symptomatic gallstones.
Authors: Friedman G.D. .
Source: American Journal Of Surgery, 1993 Apr; 165(4), p. 399-404.
PMID: 8480871
Related Citations

Exposure to engine exhaust and risk of subsequent cancer.
Authors: Van Den Eeden S.K. , Friedman G.D. .
Source: Journal Of Occupational Medicine. : Official Publication Of The Industrial Medical Association, 1993 Mar; 35(3), p. 307-11.
PMID: 7681109
Related Citations

Risk factors for pancreatic cancer: an exploratory study.
Authors: Friedman G.D. , van den Eeden S.K. .
Source: International Journal Of Epidemiology, 1993 Feb; 22(1), p. 30-7.
PMID: 8449644
Related Citations

Effect of fecal occult blood testing on mortality from colorectal cancer. A case-control study.
Authors: Selby J.V. , Friedman G.D. , Quesenberry C.P. , Weiss N.S. .
Source: Annals Of Internal Medicine, 1993-01-01 00:00:00.0; 118(1), p. 1-6.
PMID: 8416152
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