||5R35CA049761-13 Interpret this number
||Cancer Epidemiology in a Large Health Care Plan
I propose to continue our work in cancer epidemiology that has developed
at the Kaiser Permanente Medical Care Program in the past 1 1/2 decades
and has been supported for 4 years by an Outstanding Investigators Grant,
1. Continue surveillance for possible carcinogenic effects of medicinal
drugs in a cohort of 143,574 Kaiser Foundation Health Plan members using
additional data resources of the program to test hypotheses. Study newer
drugs, as appropriate, using the new region-wide pharmacy data system
that is currently being implemented.
2. Continue follow-up of a cohort of over 100,000 persons who received
multiphasic health checkups plus research questionnaires on smoking and
alcohol use, to study cancer-producing effects of various tobacco
products, alcoholic beverages, marijuana and other factors.
3. Continue to conduct nested case-control studies of possible
chemopreventive factors in the above multiphasic cohort using a large
collection of frozen serum specimens.
4. Continue to conduct studies of the efficacy of screening tests in
preventing mortality from cancer.
5. Employ the flexibility afforded by the Outstanding Investigator Grant
to study promising new leads concerning cancer etiology and control in
the extensive data resources of Kaiser Permanente.