Grant Number:	5R35CA049761-13 Interpret this number
Primary Investigator:	Friedman, Gary
Organization:	Stanford University
Project Title:	Cancer Epidemiology in a Large Health Care Plan
Fiscal Year:	2000

I propose to continue our work in cancer epidemiology that has developed at the Kaiser Permanente Medical Care Program in the past 1 1/2 decades and has been supported for 4 years by an Outstanding Investigators Grant, as follows: 1. Continue surveillance for possible carcinogenic effects of medicinal drugs in a cohort of 143,574 Kaiser Foundation Health Plan members using additional data resources of the program to test hypotheses. Study newer drugs, as appropriate, using the new region-wide pharmacy data system that is currently being implemented. 2. Continue follow-up of a cohort of over 100,000 persons who received multiphasic health checkups plus research questionnaires on smoking and alcohol use, to study cancer-producing effects of various tobacco products, alcoholic beverages, marijuana and other factors. 3. Continue to conduct nested case-control studies of possible chemopreventive factors in the above multiphasic cohort using a large collection of frozen serum specimens. 4. Continue to conduct studies of the efficacy of screening tests in preventing mortality from cancer. 5. Employ the flexibility afforded by the Outstanding Investigator Grant to study promising new leads concerning cancer etiology and control in the extensive data resources of Kaiser Permanente.




Short-term chloral hydrate administration and cancer in humans.
Authors: Haselkorn T. , Whittemore A.S. , Udaltsova N. , Friedman G.D. .
Source: Drug Safety : An International Journal Of Medical Toxicology And Drug Experience, 2006; 29(1), p. 67-77.
PMID: 16454535
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The risk for malignant primary adult-onset glioma in a large, multiethnic, managed-care cohort: cigarette smoking and other lifestyle behaviors.
Authors: Efird J.T. , Friedman G.D. , Sidney S. , Klatsky A. , Habel L.A. , Udaltsova N.V. , Van den Eeden S. , Nelson L.M. .
Source: Journal Of Neuro-oncology, 2004 May; 68(1), p. 57-69.
PMID: 15174522
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C-reactive protein, Helicobacter pylori, Chlamydia pneumoniae, cytomegalovirus and risk for myocardial infarction.
Authors: Witherell H.L. , Smith K.L. , Friedman G.D. , Ley C. , Thom D.H. , Orentreich N. , Vogelman J.H. , Parsonnet J. .
Source: Annals Of Epidemiology, 2003 Mar; 13(3), p. 170-7.
PMID: 12604160
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Risk of subsequent cancer following invasive or in situ squamous cell skin cancer.
Authors: Efird J.T. , Friedman G.D. , Habel L. , Tekawa I.S. , Nelson L.M. .
Source: Annals Of Epidemiology, 2002 Oct; 12(7), p. 469-75.
PMID: 12377424
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Risk factors for synchronous primary endometrial and ovarian cancers.
Authors: Herrinton L.J. , Voigt L.F. , Weiss N.S. , Beresford S.A. , Wingo P.A. .
Source: Annals Of Epidemiology, 2001 Nov; 11(8), p. 529-33.
PMID: 11709271
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Exposure to environmental tobacco smoke: association with personal characteristics and self reported health conditions.
Authors: Iribarren C. , Friedman G.D. , Klatsky A.L. , Eisner M.D. .
Source: Journal Of Epidemiology And Community Health, 2001 Oct; 55(10), p. 721-8.
PMID: 11553655
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Cohort study of thyroid cancer in a San Francisco Bay area population.
Authors: Iribarren C. , Haselkorn T. , Tekawa I.S. , Friedman G.D. .
Source: International Journal Of Cancer, 2001-09-01 00:00:00.0; 93(5), p. 745-50.
PMID: 11477590
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Concomitant medication use in postmenopausal women using estrogen therapy.
Authors: Small R. , Friedman G.D. , Ettinger B. .
Source: Menopause (new York, N.y.), 2001 Summer; 8(2), p. 120-6.
PMID: 11256872
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Histological classification of gastric adenocarcinoma for epidemiological research: concordance between pathologists.
Authors: Shibata A. , Longacre T.A. , Puligandla B. , Parsonnet J. , Habel L.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2001 Jan; 10(1), p. 75-8.
PMID: 11205493
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Association of basal cell skin cancers with other cancers (United States).
Authors: Friedman G.D. , Tekawa I.S. .
Source: Cancer Causes & Control : Ccc, 2000 Dec; 11(10), p. 891-7.
PMID: 11142523
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Colon cancer screening, lifestyle, and risk of colon cancer.
Authors: Slattery M.L. , Edwards S.L. , Ma K.N. , Friedman G.D. .
Source: Cancer Causes & Control : Ccc, 2000 Jul; 11(6), p. 555-63.
PMID: 10880038
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Spousal concordance for cancer incidence: A cohort study.
Authors: Friedman G.D. , Quesenberry C.P. .
Source: Cancer, 1999-12-01 00:00:00.0; 86(11), p. 2413-9.
PMID: 10590385
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Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary disease, and cancer in men.
Authors: Iribarren C. , Tekawa I.S. , Sidney S. , Friedman G.D. .
Source: The New England Journal Of Medicine, 1999-06-10 00:00:00.0; 340(23), p. 1773-80.
PMID: 10362820
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Barbiturates and lung cancer: a re-evaluation.
Authors: Friedman G.D. , Habel L.A. .
Source: International Journal Of Epidemiology, 1999 Jun; 28(3), p. 375-9.
PMID: 10405836
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Cholecystectomy and the risk of colon cancer.
Authors: Todoroki I. , Friedman G.D. , Slattery M.L. , Potter J.D. , Samowitz W. .
Source: The American Journal Of Gastroenterology, 1999 Jan; 94(1), p. 41-6.
PMID: 9934729
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Barbiturates, smoking, and bladder cancer risk.
Authors: Habel L.A. , Bull S.A. , Friedman G.D. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1998 Nov; 7(11), p. 1049-50.
PMID: 9829715
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Cigarette smoking and risk of non-Hodgkin's lymphoma subtypes.
Authors: Herrinton L.J. , Friedman G.D. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1998 Jan; 7(1), p. 25-8.
PMID: 9456239
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Risk for gastric lymphoma in persons with CagA+ and CagA- Helicobacter pylori infection.
Authors: Witherell H.L. , Hansen S. , Jellum E. , Orentreich N. , Vogelman J.H. , Parsonnet J. .
Source: The Journal Of Infectious Diseases, 1997 Dec; 176(6), p. 1641-4.
PMID: 9395383
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Marijuana use and cancer incidence (California, United States).
Authors: Sidney S. , Quesenberry C.P. , Friedman G.D. , Tekawa I.S. .
Source: Cancer Causes & Control : Ccc, 1997 Sep; 8(5), p. 722-8.
PMID: 9328194
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Marijuana use and mortality.
Authors: Sidney S. , Beck J.E. , Tekawa I.S. , Quesenberry C.P. , Friedman G.D. .
Source: American Journal Of Public Health, 1997 Apr; 87(4), p. 585-90.
PMID: 9146436
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Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection.
Authors: Parsonnet J. , Friedman G.D. , Orentreich N. , Vogelman H. .
Source: Gut, 1997 Mar; 40(3), p. 297-301.
PMID: 9135515
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Physical activity and colon cancer: a public health perspective.
Authors: Slattery M.L. , Edwards S.L. , Ma K.N. , Friedman G.D. , Potter J.D. .
Source: Annals Of Epidemiology, 1997 Feb; 7(2), p. 137-45.
PMID: 9099401
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Tobacco use and colon cancer.
Authors: Slattery M.L. , Potter J.D. , Friedman G.D. , Ma K.N. , Edwards S. .
Source: International Journal Of Cancer, 1997-01-27 00:00:00.0; 70(3), p. 259-64.
PMID: 9033624
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Depression, smoking, and lung cancer.
Authors: Friedman G.D. .
Source: American Journal Of Epidemiology, 1996-12-15 00:00:00.0; 144(12), p. 1104-6.
PMID: 8956622
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Can hematuria be a predictor as well as a symptom or sign of bladder cancer?
Authors: Friedman G.D. , Carroll P.R. , Cattolica E.V. , Hiatt R.A. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1996 Dec; 5(12), p. 993-6.
PMID: 8959322
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A description of age, sex, and site distributions of colon carcinoma in three geographic areas.
Authors: Slattery M.L. , Friedman G.D. , Potter J.D. , Edwards S. , Caan B.J. , Samowitz W. .
Source: Cancer, 1996-10-15 00:00:00.0; 78(8), p. 1666-70.
PMID: 8859178
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The incidence of non-Hodgkin's lymphoma and its histologic subtypes in Asian migrants to the United States and their descendants.
Authors: Herrinton L.J. , Goldoft M. , Schwartz S.M. , Weiss N.S. .
Source: Cancer Causes & Control : Ccc, 1996 Mar; 7(2), p. 224-30.
PMID: 8740735
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Reduced mortality associated with long-term postmenopausal estrogen therapy.
Authors: Ettinger B. , Friedman G.D. , Bush T. , Quesenberry C.P. .
Source: Obstetrics And Gynecology, 1996 Jan; 87(1), p. 6-12.
PMID: 8532268
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Case-control study of digital-rectal screening in relation to mortality from cancer of the distal rectum.
Authors: Herrinton L.J. , Selby J.V. , Friedman G.D. , Quesenberry C.P. , Weiss N.S. .
Source: American Journal Of Epidemiology, 1995-11-01 00:00:00.0; 142(9), p. 961-4.
PMID: 7572977
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Transferrin saturation and risk of cancer.
Authors: Herrinton L.J. , Friedman G.D. , Baer D. , Selby J.V. .
Source: American Journal Of Epidemiology, 1995-10-01 00:00:00.0; 142(7), p. 692-8.
PMID: 7572938
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Seasonal variation in vitamin D, vitamin D-binding protein, and dehydroepiandrosterone: risk of prostate cancer in black and white men.
Authors: Corder E.H. , Friedman G.D. , Vogelman J.H. , Orentreich N. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1995 Sep; 4(6), p. 655-9.
PMID: 8547833
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Cholecystectomy not confirmed as a risk factor for pancreatic cancer.
Authors: Friedman G.D. .
Source: International Journal Of Cancer, 1995-05-29 00:00:00.0; 61(5), p. 745-6.
PMID: 7768651
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Mentholated cigarette use and lung cancer.
Authors: Sidney S. , Tekawa I.S. , Friedman G.D. , Sadler M.C. , Tashkin D.P. .
Source: Archives Of Internal Medicine, 1995-04-10 00:00:00.0; 155(7), p. 727-32.
PMID: 7695461
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Prostate-specific antigen as predictor of prostate cancer in black men and white men.
Authors: Whittemore A.S. , Lele C. , Friedman G.D. , Stamey T. , Vogelman J.H. , Orentreich N. .
Source: Journal Of The National Cancer Institute, 1995-03-01 00:00:00.0; 87(5), p. 354-60.
PMID: 7531773
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Breast cancer incidence in Asian migrants to the United States and their descendants.
Authors: Stanford J.L. , Herrinton L.J. , Schwartz S.M. , Weiss N.S. .
Source: Epidemiology (cambridge, Mass.), 1995 Mar; 6(2), p. 181-3.
PMID: 7742407
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Serum cholesterol concentration and risk of brain cancer.
Authors: Herrinton L.J. , Friedman G.D. .
Source: Bmj (clinical Research Ed.), 1995-02-11 00:00:00.0; 310(6976), p. 367-8.
PMID: 7866214
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Problems in assessing screening experience in observational studies of screening efficacy: example of urinalysis screening for bladder cancer.
Authors: Friedman G.D. , Hiatt R.A. , Quesenberry C.P. , Selby J.V. , Weiss N.S. .
Source: Journal Of Medical Screening, 1995; 2(4), p. 219-23.
PMID: 8719152
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Ovarian cancer incidence among Asian migrants to the United States and their descendants.
Authors: Herrinton L.J. , Stanford J.L. , Schwartz S.M. , Weiss N.S. .
Source: Journal Of The National Cancer Institute, 1994-09-07 00:00:00.0; 86(17), p. 1336-9.
PMID: 8064892
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Obesity and multiple myeloma.
Authors: Friedman G.D. , Herrinton L.J. .
Source: Cancer Causes & Control : Ccc, 1994 Sep; 5(5), p. 479-83.
PMID: 7999970
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Opportunities for research in dermatologic epidemiology.
Authors: Friedman G.D. .
Source: The Journal Of Investigative Dermatology, 1994 Jun; 102(6), p. 57S-58S.
PMID: 8006440
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Helicobacter pylori infection and gastric lymphoma.
Authors: Parsonnet J. , Hansen S. , Rodriguez L. , Gelb A.B. , Warnke R.A. , Jellum E. , Orentreich N. , Vogelman J.H. , Friedman G.D. .
Source: The New England Journal Of Medicine, 1994-05-05 00:00:00.0; 330(18), p. 1267-71.
PMID: 8145781
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Psychiatrically-diagnosed depression and subsequent cancer.
Authors: Friedman G.D. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1994 Jan-Feb; 3(1), p. 11-3.
PMID: 8118378
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Helicobacter pylori, pepsinogen, and risk for gastric adenocarcinoma.
Authors: Parsonnet J. , Samloff I.M. , Nelson L.M. , Orentreich N. , Vogelman J.H. , Friedman G.D. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1993 Sep-Oct; 2(5), p. 461-6.
PMID: 8220091
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Vitamin D and prostate cancer: a prediagnostic study with stored sera.
Authors: Corder E.H. , Guess H.A. , Hulka B.S. , Friedman G.D. , Sadler M. , Vollmer R.T. , Lobaugh B. , Drezner M.K. , Vogelman J.H. , Orentreich N. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 1993 Sep-Oct; 2(5), p. 467-72.
PMID: 8220092
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Coffee, tea, and mortality.
Authors: Klatsky A.L. , Armstrong M.A. , Friedman G.D. .
Source: Annals Of Epidemiology, 1993 Jul; 3(4), p. 375-81.
PMID: 8275213
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Cigarette smoking, leukemia, and multiple myeloma.
Authors: Friedman G.D. .
Source: Annals Of Epidemiology, 1993 Jul; 3(4), p. 425-8.
PMID: 8275220
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Natural history of asymptomatic and symptomatic gallstones.
Authors: Friedman G.D. .
Source: American Journal Of Surgery, 1993 Apr; 165(4), p. 399-404.
PMID: 8480871
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Exposure to engine exhaust and risk of subsequent cancer.
Authors: Van Den Eeden S.K. , Friedman G.D. .
Source: Journal Of Occupational Medicine. : Official Publication Of The Industrial Medical Association, 1993 Mar; 35(3), p. 307-11.
PMID: 7681109
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Risk factors for pancreatic cancer: an exploratory study.
Authors: Friedman G.D. , van den Eeden S.K. .
Source: International Journal Of Epidemiology, 1993 Feb; 22(1), p. 30-7.
PMID: 8449644
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Effect of fecal occult blood testing on mortality from colorectal cancer. A case-control study.
Authors: Selby J.V. , Friedman G.D. , Quesenberry C.P. , Weiss N.S. .
Source: Annals Of Internal Medicine, 1993-01-01 00:00:00.0; 118(1), p. 1-6.
PMID: 8416152
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