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Grant Details

Grant Number: 5R01CA064292-05 Interpret this number
Primary Investigator: Eley, John
Organization: Emory University
Project Title: Racial Differences in Breast Cancer Survival
Fiscal Year: 2000
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Abstract

DESCRIPTION: (Adapted from the Investigator's Abstract) The goal of this project is to examine reasons for the 3-fold survival difference observed between African-American and Caucasian women age 20-54 in Atlanta newly diagnosed with invasive breast cancer. The study focuses on three issues: 1. the extent of racial differences in the aggressiveness of breast cancers and the contribution of method of detection to racial differences in tumor aggressiveness, 2. the effects of adolescent exposure to several hormone-related breast cancer risk factors and of the method of breast cancer detection on tumor aggressiveness and on racial differences in tumor aggressiveness, and 3. the contribution of tumor aggressiveness to poorer survival among black women. This project builds on information already collected on 841 women with invasive breast cancer (246 African-American, 595 Caucasian) and 914 controls (251 African-American and 633 Caucasian) who were interviewed as part of an N.C.I. - initiated population-based, case-control study of breast cancer etiology in young women (N01-CP-95642-32). All women newly diagnosed with invasive breast cancer in Fulton, DeKalb and Cobb Counties in Georgia during 5/1/90 - 12/31/92 were rapidly identified and 87% of African-American women with breast cancer and 90 percent of Caucasian women with breast cancer were interviewed. A sample of controls was selected from the same counties during the same time period and 83 percent were interviewed. This patient cohort will be followed for recurrence and mortality through April 2000. Patient interview information is already available on screening history, method of cancer detection and on the primary risk factors of interest: early menarche and adolescent exposure to oral contraceptive use, spontaneous and induced abortion, childbirth, and obesity. A detailed pathologic review will be conducted and two markers of cell proliferation will be measured in formalin-fixed, paraffin embedded tissues: S-phase fraction determined by flow cytometry and Ki-67 by immunocytochemical staining. Four other well characterized markers of tumor aggressiveness are a focus of this analysis: aneuploidy (DNA content measured by flow cytometry), expression of c-erbB-2 and p53 gene products (detected by immunocytochemistry), and vascular response (determined by image quantification of vascular density). The study includes information on a variety of additional characteristics which affect risk and/or survival.

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Publications

Genome-wide copy number alterations in subtypes of invasive breast cancers in young white and African American women.
Authors: Loo L.W. , Wang Y. , Flynn E.M. , Lund M.J. , Bowles E.J. , Buist D.S. , Liff J.M. , Flagg E.W. , Coates R.J. , Eley J.W. , et al. .
Source: Breast cancer research and treatment, 2011 May; 127(1), p. 297-308.
EPub date: 2011-01-25.
PMID: 21264507
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The epidemiology of triple-negative breast cancer, including race.
Authors: Trivers K.F. , Lund M.J. , Porter P.L. , Liff J.M. , Flagg E.W. , Coates R.J. , Eley J.W. .
Source: Cancer causes & control : CCC, 2009 Sep; 20(7), p. 1071-82.
EPub date: 2009-04-03.
PMID: 19343511
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Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GA.
Authors: Lund M.J. , Trivers K.F. , Porter P.L. , Coates R.J. , Leyland-Jones B. , Brawley O.W. , Flagg E.W. , O'Regan R.M. , Gabram S.G. , Eley J.W. .
Source: Breast cancer research and treatment, 2009 Jan; 113(2), p. 357-70.
EPub date: 2008-03-07.
PMID: 18324472
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Factors associated with advanced disease stage at diagnosis in a population-based study of patients with newly diagnosed breast cancer.
Authors: Hahn K.M. , Bondy M.L. , Selvan M. , Lund M.J. , Liff J.M. , Flagg E.W. , Brinton L.A. , Porter P. , Eley J.W. , Coates R.J. .
Source: American journal of epidemiology, 2007-11-01; 166(9), p. 1035-44.
EPub date: 2007-08-09.
PMID: 17690220
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Racial differences in the expression of cell cycle-regulatory proteins in breast carcinoma.
Authors: Porter P.L. , Lund M.J. , Lin M.G. , Yuan X. , Liff J.M. , Flagg E.W. , Coates R.J. , Eley J.W. .
Source: Cancer, 2004-06-15; 100(12), p. 2533-42.
PMID: 15197793
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Racial differences in diagnosis, treatment, and clinical delays in a population-based study of patients with newly diagnosed breast carcinoma.
Authors: Gwyn K. , Bondy M.L. , Cohen D.S. , Lund M.J. , Liff J.M. , Flagg E.W. , Brinton L.A. , Eley J.W. , Coates R.J. .
Source: Cancer, 2004-04-15; 100(8), p. 1595-604.
PMID: 15073845
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