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Grant Details

Grant Number: 5R01CA035464-17 Interpret this number
Primary Investigator: Tanner, Martin
Organization: Northwestern University
Project Title: Nonparametric Analysis of Censored Data
Fiscal Year: 2000
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Abstract

1. Mixtures and Hierarchical Mixtures of Cox Experts The goal during the present grant period will be to study and extend a mixture model which combines features of the usual Cox proportional hazards model with those of mixtures-of-experts. The first subaim will be to compare the mixture of Cox experts approach to spline-based methods. The second subaim is to develop and study a Markov chain Monte Carlo approach to inference for the mixture of Cox experts. The third subaim will be to develop, study and apply a hierarchical mixture of Cox experts architecture. 2. Semiparametric Bayesian Inference for Regression models Seifu, Severini and Tanner (1997) present a model for Bayesian inference in a linear model with independent and identically distributed errors that does not require the specification of parametric family of densities for the error distribution. The focus of this specific aim is to extend this work to the censored regression case. Both the one-sample and regression cases will be considered. This new methodology for censored data problem will be examined via stimulation studies and validated using real data. 3. Approximate Monte Carlo Conditional Inference Kolassa and Tanner (1997) present an algorithm for approximate Frequentist conditional inference on two or more parameters. The method makes use of the double saddle point approximations of Skovgaard (1987) to the conditional cumulative distribution function of a sufficient statistic given the remaining sufficient statistics. This approximation is then used in conjunction with non-iterative simulation methods to generate a sample from the distribution that approximates the joint distribution of the sufficient statistics associated with the parameters of interest conditional on the observed values of the sufficient statistics associated with the nuisance parameters. The focus of this specific aim is to further study and apply the algorithm of Kolassa and Tanner (1997) to general problems in biostatistics. The algorithm will be applied to situations such as general hierarchical log-linear models for multiway contingency tables and logistic regression. The algorithm will be compared via simulation and on real data sets to alternative methods for exact conditional inference. The methodology will be improved by replacing the Skovgaard approximation with a higher-order approximation due to Kolassa (1996). This methodology will also be applied to a variety of models in the generalized linear model family for which no competing exact or higher-order methods are available.

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Publications

On the approximation rate of hierarchical mixtures-of-experts for generalized linear models.
Authors: Jiang W. , Tanner M.A. .
Source: Neural computation, 1999-07-01; 11(5), p. 1183-98.
PMID: 10418162
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Mixtures of proportional hazards regression models.
Authors: Rosen O. , Tanner M. .
Source: Statistics in medicine, 1999-05-15; 18(9), p. 1119-31.
PMID: 10378260
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Approximate Monte Carlo conditional inference in exponential families.
Authors: Kolassa J.E. , Tanner M.A. .
Source: Biometrics, 1999 Mar; 55(1), p. 246-51.
PMID: 11318162
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Bayesian inference for hierarchical mixtures-of-experts with applications to regression and classification.
Authors: Jacobs R.A. , Tanner M.A. , Peng F. .
Source: Statistical methods in medical research, 1996 Dec; 5(4), p. 375-90.
PMID: 9004379
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A comparison of size and power calculations for the Wilcoxon statistic for ordered categorical data.
Authors: Kolassa J.E. .
Source: Statistics in medicine, 1995-07-30; 14(14), p. 1577-81.
PMID: 7481194
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One hundred autotransplants for relapsed or refractory Hodgkin's disease and lymphoma: value of pretransplant disease status for predicting outcome.
Authors: Rapoport A.P. , Rowe J.M. , Kouides P.A. , Duerst R.A. , Abboud C.N. , Liesveld J.L. , Packman C.H. , Eberly S. , Sherman M. , Tanner M.A. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993 Dec; 11(12), p. 2351-61.
PMID: 8246024
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Treatment of relapsed or refractory Hodgkin disease and non-Hodgkin lymphoma with high-dose chemoradiotherapy followed by unstimulated autologous peripheral stem cell rescue.
Authors: Rapoport A.P. , Rowe J.M. , Heal J.M. , Tanner M.A. , DiPersio J.F. .
Source: American journal of hematology, 1992 Jun; 40(2), p. 86-92.
PMID: 1585923
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Applications of multiple imputation to the analysis of censored regression data.
Authors: Wei G.C. , Tanner M.A. .
Source: Biometrics, 1991 Dec; 47(4), p. 1297-309.
PMID: 1786320
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Further analysis of the time factor in squamous cell carcinoma of the tonsillar region.
Authors: Fowler J.F. , Tanner M.A. , Bataini J.P. , Asselain B. , Bernier J. , Lave C. .
Source: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1990 Nov; 19(3), p. 237-44.
PMID: 2281153
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Interactions of thymidine, hyperthermia, and cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) in human T-cell leukemia.
Authors: Cohen J.D. , Robins H.I. , Schmitt C.L. , Tanner M.A. .
Source: Cancer research, 1989-11-01; 49(21), p. 5805-9.
PMID: 2676150
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Clonogenic cells and rat mammary cancer: effects of hormones, X rays, and fission neutrons.
Authors: Kamiya K. , Higgins P.D. , Tanner M.A. , Yokoro K. , Clifton K.H. .
Source: Radiation research, 1989 Nov; 120(2), p. 323-38.
PMID: 2616743
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Fine-needle aspiration for breast mass diagnosis.
Authors: Wolberg W.H. , Tanner M.A. , Loh W.Y. .
Source: Archives of surgery (Chicago, Ill. : 1960), 1989 Jul; 124(7), p. 814-8.
PMID: 2742482
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Psychosexual adaptation to breast cancer surgery.
Authors: Wolberg W.H. , Romsaas E.P. , Tanner M.A. , Malec J.F. .
Source: Cancer, 1989-04-15; 63(8), p. 1645-55.
PMID: 2924271
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Inhibition of carcinoma formation and of vascular invasion in grafts of radiation-initiated thyroid clonogens by unirradiated thyroid cells.
Authors: Watanabe H. , Tanner M.A. , Domann F.E. , Gould M.N. , Clifton K.H. .
Source: Carcinogenesis, 1988 Aug; 9(8), p. 1329-35.
PMID: 3402028
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Diagnostic schemes for fine needle aspirates of breast masses.
Authors: Wolberg W.H. , Tanner M.A. , Loh W.Y. .
Source: Analytical and quantitative cytology and histology, 1988 Jun; 10(3), p. 225-8.
PMID: 3044383
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Statistical approach to fine needle aspiration diagnosis of breast masses.
Authors: Wolberg W.H. , Tanner M.A. , Loh W.Y. , Vanichsetakul N. .
Source: Acta cytologica, 1987 Nov-Dec; 31(6), p. 737-41.
PMID: 3425134
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Enhancement of misonidazole chemopotentiation by mild hyperthermia (41 degrees C) in vitro and selective enhancement in vivo.
Authors: Mulcahy R.T. , Gipp J.J. , Tanner M.A. .
Source: International journal of radiation biology and related studies in physics, chemistry, and medicine, 1987 Jul; 52(1), p. 57-65.
PMID: 3496311
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Factors influencing options in primary breast cancer treatment.
Authors: Wolberg W.H. , Tanner M.A. , Romsaas E.P. , Trump D.L. , Malec J.F. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987 Jan; 5(1), p. 68-74.
PMID: 3806161
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Assessment of radiogenic cancer initiation frequency per clonogenic rat mammary cell in vivo.
Authors: Clifton K.H. , Tanner M.A. , Gould M.N. .
Source: Cancer research, 1986 May; 46(5), p. 2390-5.
PMID: 3697982
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Systematic optimization of the clonal growth of human primary breast carcinoma cells.
Authors: Besch G.J. , Tanner M.A. , Howard S.P. , Wolberg W.H. , Gould M.N. .
Source: Cancer research, 1986 May; 46(5), p. 2306-13.
PMID: 2421876
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Radiation survival of human mammary carcinoma cells: criteria for an agar-based clonogenic assay.
Authors: Besch G.J. , Tanner M.A. , Sattler C.A. , Wolberg W.H. , Howard S.P. , Gould M.N. .
Source: International journal of radiation oncology, biology, physics, 1986 Jan; 12(1), p. 75-81.
PMID: 3943995
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Modeling ordinal scale disagreement.
Authors: Tanner M.A. , Young M.A. .
Source: Psychological bulletin, 1985 Sep; 98(2), p. 408-15.
PMID: 3901069
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Irradiation and prolactin effects on rat mammary carcinogenesis: intrasplenic pituitary and estrone capsule implants.
Authors: Clifton K.H. , Yasukawa-Barnes J. , Tanner M.A. , Haning R.V. .
Source: Journal of the National Cancer Institute, 1985 Jul; 75(1), p. 167-75.
PMID: 3859689
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