The objective of this Program Project is the multidisciplinary study of the
etiology of gastric cancer, focused on premalignant lesions. The current
cycle is based on findings of the previous funding cycles which have led to
the postulation and refinement of an etiologic model. The first project is
the continuation of a chemoprevention trial designed to determine the
efficacy of antioxidant supplementation (ascorbic acid and/or beta
carotene) and/or anti-Helicobacter pylori treatment in retarding the
progression of the premalignant process. The second project provides an
evaluation of the histological and molecular endpoints used in all the
other components of the program. All of the proposed studies are closely
interrelated and complementary. They explore the mechanisms of action of
the factors involved in the gastric precancerous process and its possible
inhibition. These studies have the potential to provide important new
knowledge about gastric carcinogenesis and to contribute to the goal of
primary prevention of this common cancer.
Error Notice
The database may currently be offline for maintenance and should be operational soon. If not, we have been notified of this error and will be reviewing it shortly.
We apologize for the inconvenience.
- The DCCPS Team.
