Grant Details
Grant Number: |
1R01CA084964-01 Interpret this number |
Primary Investigator: |
Strom, Sara |
Organization: |
University Of Texas Md Anderson Can Ctr |
Project Title: |
Prostate Cancer in Mexicans Americans & African American |
Fiscal Year: |
1999 |
Abstract
Prostate cancer is the leading incident cancer and the second leading cause of cancer deaths among men in the three major U.S. ethnic groups. However, those rates differ markedly among these groups. The racial differences in prostate cancer incidence and mortality could provide important clues to the etiology of the disease that could be exploited to further our understanding of prostate carcinogenesis. Prostate cancer is a model site for the study of the interplay of gene-environment interactions. In this proposed study, we will examine environmental factors in concert with genetic susceptibility in two ethnic groups with contrasting prostate cancer rates, African Americans and Mexican Americans, from a well-defined geographic area. We propose a population-based case-control study of genotypic, phenotypic, environmental and sociodemographic contributors to the etiology of prostate cancer in African Americans and Mexican Americans who are residents of the Houston area (Harris County, Texas). We will enroll 550 prostate cancer cases (200 Mexican Americans and 350 African Americans) and 750 controls (400 Mexican Americans and 350 African Americans) matched on age and race/ethnicity. Constitutional markers of genetic susceptibility and hormonal modulation, such as androgen receptor, 5-alpha-reductase type II, CYP17, CYP1B1, 3-beta-hydroxsteroid type II and vitamin D receptor, will be analyzed to determine if genotypic differences are associated with prostate cancer risk. Few studies have focused on minority populations, especially Hispanics, from a defined geographic area. Understanding how genetic predisposition and exogenous exposures interact to determine prostate cancer susceptibility will allow the development of more effective ethnic-specific prevention strategies.
Publications
Integrated Hedgehog signaling is induced following castration in human and murine prostate cancers.
Authors: Efstathiou E.
, Karlou M.
, Wen S.
, Hoang A.
, Pettaway C.A.
, Pisters L.L.
, Maity S.
, Troncoso P.
, Logothetis C.J.
.
Source: The Prostate, 2013 Jan; 73(2), p. 153-61.
PMID: 22753310
Related Citations
Racial/ethnic differences in treatment discussed, preferred, and received for prostate cancer in a tri-ethnic population.
Authors: Hosain G.M.
, Sanderson M.
, Du X.L.
, Chan W.
, Strom S.S.
.
Source: American Journal Of Men's Health, 2012 May; 6(3), p. 249-57.
PMID: 22419652
Related Citations
Racial/ethnic differences in predictors of PSA screening in a tri-ethnic population.
Authors: Hosain G.M.
, Sanderson M.
, Du X.L.
, Chan W.
, Strom S.S.
.
Source: Central European Journal Of Public Health, 2011 Mar; 19(1), p. 30-4.
PMID: 21526653
Related Citations
Saturated fat intake predicts biochemical failure after prostatectomy.
Authors: Strom S.S.
, Yamamura Y.
, Forman M.R.
, Pettaway C.A.
, Barrera S.L.
, DiGiovanni J.
.
Source: International Journal Of Cancer, 2008-06-01 00:00:00.0; 122(11), p. 2581-5.
PMID: 18324626
Related Citations
Prostate cancer in Mexican-Americans: identification of risk factors.
Authors: Strom S.S.
, Yamamura Y.
, Flores-Sandoval F.N.
, Pettaway C.A.
, Lopez D.S.
.
Source: The Prostate, 2008-04-01 00:00:00.0; 68(5), p. 563-70.
PMID: 18247399
Related Citations
Initial modulation of the tumor microenvironment accounts for thalidomide activity in prostate cancer.
Authors: Efstathiou E.
, Troncoso P.
, Wen S.
, Do K.A.
, Pettaway C.A.
, Pisters L.L.
, McDonnell T.J.
, Logothetis C.J.
.
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2007-02-15 00:00:00.0; 13(4), p. 1224-31.
PMID: 17317833
Related Citations
Human sensitivity to PhIP: a novel marker for prostate cancer risk.
Authors: El-Zein R.
, Etzel C.J.
, Lopez M.S.
, Gu Y.
, Spitz M.R.
, Strom S.S.
.
Source: Mutation Research, 2006-10-10 00:00:00.0; 601(1-2), p. 1-10.
EPub date: 2006-10-10 00:00:00.0.
PMID: 16889804
Related Citations
Influence of obesity on biochemical and clinical failure after external-beam radiotherapy for localized prostate cancer.
Authors: Strom S.S.
, Kamat A.M.
, Gruschkus S.K.
, Gu Y.
, Wen S.
, Cheung M.R.
, Pisters L.L.
, Lee A.K.
, Rosser C.J.
, Kuban D.A.
.
Source: Cancer, 2006-08-01 00:00:00.0; 107(3), p. 631-9.
PMID: 16802288
Related Citations
Obesity, weight gain, and risk of biochemical failure among prostate cancer patients following prostatectomy.
Authors: Strom S.S.
, Wang X.
, Pettaway C.A.
, Logothetis C.J.
, Yamamura Y.
, Do K.A.
, Babaian R.J.
, Troncoso P.
.
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2005-10-01 00:00:00.0; 11(19 Pt 1), p. 6889-94.
PMID: 16203779
Related Citations
Chromosomal instability in peripheral blood lymphocytes and risk of prostate cancer.
Authors: El-Zein R.
, Gu Y.
, Sierra M.S.
, Spitz M.R.
, Strom S.S.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2005 Mar; 14(3), p. 748-52.
PMID: 15767363
Related Citations
Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis.
Authors: Liu Z.
, Wang L.E.
, Strom S.S.
, Spitz M.R.
, Babaian R.J.
, DiGiovanni J.
, Wei Q.
.
Source: Molecular Carcinogenesis, 2003 Mar; 36(3), p. 123-9.
PMID: 12619034
Related Citations