Grant Number:	2R01CA060068-05A1 Interpret this number
Primary Investigator:	Cella, David
Organization:	Evanston Northwestern Healthcare Res Ins
Project Title:	Item Banking and Cat for Quality of Life Outcomes
Fiscal Year:	1999

If quality of life (QOL) data are to be useful in clinical settings, they must be accurate, precise, responsive to meaningful change, and interpretable. Making a step in that direction, R01 CA60068 ( Quality of life evaluation in oncology ) was a three-year project with the primary aim of developing a common QOL metric ( Q-score ) and a common language for QOL data. Under this grant we have developed standardized scores for five commonly used QOL questionnaires: The Cancer Rehabilitation Evaluation System, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core, the Functional Assessment of Cancer Therapy-General, the Medical Outcomes Study 36-Item Short-Form Health Survey and the Quality of Life Index. The primary aim of the current project has been accomplished, leading to the proposed logical extension of work which will utilize Rasch measurement and confirmatory factor analysis (CFA) to: 1) Construct and extend an item bank for quality of life (QOL) outcomes; and 2) Develop and pilot QOL computerized adaptive testing (CAT) in clinical settings with cancer, HIV/AIDS and stroke patients. These two specific aims will be accomplished through four projects which will span five years: Project 1: Construct an initial item bank (database) comprised of previously calibrated and tested questions from the RAND-36 (aka SF-36), EORTC QLQ-C30, CARES-SF, FACT-G, and QLI. Preliminary item difficulties for the complete set of questions (Overall QOL) and for subsets of questions which define and measure physical well-being (PWB) and mental well-being (MWB) will then be established; Project 2: Acquire items into the bank which fill current item difficulty gaps in PWB and MWB, and which allow for possible building of a third summary QOL dimensions, social well-being (SWB), and overall QOL (n=195). The acquisition task will be done in a way which allows for future selection of items which are shown to be sensitive to relevant clinical and QOL change; Project 3: Test the equivalence of computer-based testing (CBT) versus paper-and-pencil (P and P) assessment across three diagnostic patient groups: Cancer, HIV/AIDS and stroke (n=600); and Project 4: Develop a CAT platform for QOL assessment (n=45), then pilot in clinical settings (n=200), test the equivalence of measures obtained via CAT versus conventional assessment, and explore sensitivity to clinical change.




Positive and negative psychosocial impacts on cancer survivors.
Authors: Yao G. , Lai J.S. , Garcia S.F. , Yount S. , Cella D. .
Source: Scientific Reports, 2023-09-07 00:00:00.0; 13(1), p. 14749.
EPub date: 2023-09-07 00:00:00.0.
PMID: 37679401
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Positive and negative psychosocial impacts on cancer survivors.
Authors: Yao G. , Lai J.S. , Garcia S.F. , Yount S. , Cella D. .
Source: Scientific Reports, 2023-09-07 00:00:00.0; 13(1), p. 14749.
EPub date: 2023-09-07 00:00:00.0.
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Personalized Immunotherapy of Patients: Defining by Single-cell RNA-seq with Artificial Intelligence.
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Source: Medical Research Archives, 2023 Aug; 11(8), .
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Machine-learning Modeling for Personalized Immunotherapy- An Evaluation Module.
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Clinical validity of PROMIS Depression, Anxiety, and Anger across diverse clinical samples.
Authors: Schalet B.D. , Pilkonis P.A. , Yu L. , Dodds N. , Johnston K.L. , Yount S. , Riley W. , Cella D. .
Source: Journal Of Clinical Epidemiology, 2016 May; 73, p. 119-27.
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Evidence from diverse clinical populations supported clinical validity of PROMIS pain interference and pain behavior.
Authors: Askew R.L. , Cook K.F. , Revicki D.A. , Cella D. , Amtmann D. .
Source: Journal Of Clinical Epidemiology, 2016 May; 73, p. 103-11.
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PROMIS Fatigue Item Bank had Clinical Validity across Diverse Chronic Conditions.
Authors: Cella D. , Lai J.S. , Jensen S.E. , Christodoulou C. , Junghaenel D.U. , Reeve B.B. , Stone A.A. .
Source: Journal Of Clinical Epidemiology, 2016 May; 73, p. 128-34.
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Promis Measures Of Pain, Fatigue, Negative Affect, Physical Function, And Social Function Demonstrated Clinical Validity Across A Range Of Chronic Conditions
Authors: Cook K.F. , Jensen S.E. , Schalet B.D. , Beaumont J.L. , Amtmann D. , Czajkowski S. , Dewalt D.A. , Fries J.F. , Pilkonis P.A. , Reeve B.B. , et al. .
Source: Journal Of Clinical Epidemiology, 2016 May; 73, p. 89-102.
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Validity of PROMIS physical function measured in diverse clinical samples.
Authors: Schalet B.D. , Hays R.D. , Jensen S.E. , Beaumont J.L. , Fries J.F. , Cella D. .
Source: Journal Of Clinical Epidemiology, 2016 May; 73, p. 112-8.
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Bringing PROMIS to practice: brief and precise symptom screening in ambulatory cancer care.
Authors: Wagner L.I. , Schink J. , Bass M. , Patel S. , Diaz M.V. , Rothrock N. , Pearman T. , Gershon R. , Penedo F.J. , Rosen S. , et al. .
Source: Cancer, 2015-03-15 00:00:00.0; 121(6), p. 927-34.
EPub date: 2015-03-15 00:00:00.0.
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Setting standards for severity of common symptoms in oncology using the PROMIS item banks and expert judgment.
Authors: Cella D. , Choi S. , Garcia S. , Cook K.F. , Rosenbloom S. , Lai J.S. , Tatum D.S. , Gershon R. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2014 Dec; 23(10), p. 2651-61.
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Self-reported cognitive concerns and abilities: two sides of one coin?
Authors: Lai J.S. , Wagner L.I. , Jacobsen P.B. , Cella D. .
Source: Psycho-oncology, 2014 Oct; 23(10), p. 1133-41.
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Development Of A Measure Of Asthma-specific Quality Of Life Among Adults
Authors: Eberhart N.K. , Sherbourne C.D. , Edelen M.O. , Stucky B.D. , Sin N.L. , Lara M. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2014 Apr; 23(3), p. 837-48.
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Development And Validation Of The Functional Assessment Of Chronic Illness Therapy Treatment Satisfaction (facit Ts) Measures
Authors: Peipert J.D. , Beaumont J.L. , Bode R. , Cella D. , Garcia S.F. , Hahn E.A. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2014 Apr; 23(3), p. 815-24.
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Have a little faith: measuring the impact of illness on positive and negative aspects of faith.
Authors: Salsman J.M. , Garcia S.F. , Lai J.S. , Cella D. .
Source: Psycho-oncology, 2012 Dec; 21(12), p. 1357-61.
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Comparing higher order models for the EORTC QLQ-C30.
Authors: Gundy C.M. , Fayers P.M. , Groenvold M. , Petersen M.A. , Scott N.W. , Sprangers M.A. , Velikova G. , Aaronson N.K. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2012 Nov; 21(9), p. 1607-17.
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Neuro-qol: Brief Measures Of Health-related Quality Of Life For Clinical Research In Neurology
Authors: Cella,D. , Lai,J.S. , Nowinski,C.J. , Victorson,D. , Peterman,A. , Miller,D. , Bethoux,F. , Heinemann,A. , Rubin,S. , Cavazos,J.E. , et al. .
Source: Neurology, 2012-06-05 00:00:00.0; 78(23), p. 1860-7.
PMID: 22573626
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The psychosocial impact of cancer: evidence in support of independent general positive and negative components.
Authors: Lai J.S. , Garcia S.F. , Salsman J.M. , Rosenbloom S. , Cella D. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2012 Mar; 21(2), p. 195-207.
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Developing an emotional distress item bank for cancer patients.
Authors: Heinemann A.W. , Bode R.K. , Rosenbloom S. , Cella D. .
Source: Journal Of Applied Measurement, 2012; 13(1), p. 97-113.
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Minimally important differences were estimated for six Patient-Reported Outcomes Measurement Information System-Cancer scales in advanced-stage cancer patients.
Authors: Yost K.J. , Eton D.T. , Garcia S.F. , Cella D. .
Source: Journal Of Clinical Epidemiology, 2011 May; 64(5), p. 507-16.
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Age-associated differences in fatigue among patients with cancer.
Authors: Butt Z. , Rao A.V. , Lai J.S. , Abernethy A.P. , Rosenbloom S.K. , Cella D. .
Source: Journal Of Pain And Symptom Management, 2010 Aug; 40(2), p. 217-23.
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A Brief Assessment Of Physical Functioning For Prostate Cancer Patients
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Is Less More? A Preliminary Investigation Of The Number Of Response Categories In Self-reported Pain
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Classical test theory and item response theory/Rasch model to assess differences between patient-reported fatigue using 7-day and 4-week recall periods.
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Source: Journal Of Clinical Epidemiology, 2009 Sep; 62(9), p. 991-7.
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Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2009 Jun; 18(5), p. 585-95.
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Evaluating the dimensionality of perceived cognitive function.
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Source: Journal Of Pain And Symptom Management, 2009 Jun; 37(6), p. 982-95.
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Source: Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer, 2008 Feb; 3(2), p. 125-9.
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Estimation of patient preference-based utility weights from the functional assessment of cancer therapy - general.
Authors: Dobrez D. , Cella D. , Pickard A.S. , Lai J.S. , Nickolov A. .
Source: Value In Health : The Journal Of The International Society For Pharmacoeconomics And Outcomes Research, 2007 Jul-Aug; 10(4), p. 266-72.
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The Sf-36 Physical And Mental Health Factors Were Confirmed In Cancer And Hiv/aids Patients
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Source: Journal Of Clinical Epidemiology, 2007 Jan; 60(1), p. 68-72.
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IRT health outcomes data analysis project: an overview and summary.
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A comparison of three sets of criteria for determining the presence of differential item functioning using ordinal logistic regression.
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Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2007; 16 Suppl 1, p. 69-84.
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Should health-related quality of life be measured in cancer symptom management clinical trials? Lessons learned using the functional assessment of cancer therapy.
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Source: Journal Of The National Cancer Institute. Monographs, 2007; (37), p. 53-60.
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Item banks and their potential applications to health status assessment in diverse populations.
Authors: Hahn E.A. , Cella D. , Bode R.K. , Gershon R. , Lai J.S. .
Source: Medical Care, 2006 Nov; 44(11 Suppl 3), p. S189-97.
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Factor analysis techniques for assessing sufficient unidimensionality of cancer related fatigue.
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Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2006 Sep; 15(7), p. 1179-90.
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Expansion of a physical function item bank and development of an abbreviated form for clinical research.
Authors: Bode R.K. , Lai J.S. , Dineen K. , Heinemann A.W. , Shevrin D. , Von Roenn J. , Cella D. .
Source: Journal Of Applied Measurement, 2006; 7(1), p. 1-15.
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An item response theory-based pain item bank can enhance measurement precision.
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Source: Journal Of Pain And Symptom Management, 2005 Sep; 30(3), p. 278-88.
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Defining higher order dimensions of self-reported health: further evidence for a two-dimensional structure.
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Source: Evaluation & The Health Professions, 2005 Jun; 28(2), p. 122-41.
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Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2004 Feb; 13(1), p. 137-54.
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Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2003 Aug; 12(5), p. 485-501.
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Issues in the development of an item bank.
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Should symptoms be scaled for intensity, frequency, or both?
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Developing an initial physical function item bank from existing sources.
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A discussion of item response theory and its applications in health status assessment.
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