DESCRIPTION: (Applicant's Description) We propose pilot and developmental
studies on the use of clinical data to study the health effects of marijuana
use. Specifically, we will assess the feasibility of studying cancer risk
based upon information regarding marijuana use that have been collected
routinely from patients entering Roswell Park Cancer Institute (RPCI) since
1982. These data require matching to medical record and tumor registry
data, evaluation of response rates and completeness, and classification by
disease and patient birth cohort and sex. We will evaluate the utility of
these data for case-control studies for the purposes of replicating recent
reports by others of risk for certain cancer types in certain patients as
well as the presence or absence of risk for other sites. Initial
investigation will focus on prostate and cervical cancer. Subsequent
studies will examine effects in other major tumor types including lung,
colorectal, ovary and breast cancers. To better understand the interaction
of risk factors and exposures in patients at risk of cancer we will examine
correlation among exposure variables across the entire population studied.
We also will conduct quality control assessments of the data to determine
the reproducibility of marijuana exposure data collected by the means we
have employed. Once these developmental steps are accomplished, this
analytic database can be used to explore new hypotheses, validate the
findings of others, and examine interactions of risks not heretofore
possible. It is also possible that it can be the basis for future
multidisciplinary efforts that link biological and/or molecular markers to
the defined epidemiologic resource. Because of the developmental nature of
the activities and the PI and sponsoring institution's limited prior
experience in drug abuse research, this application is made under the Small
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