Grant Number:	5R01CA077290-02 Interpret this number
Primary Investigator:	Rohan, Thomas
Organization:	University Of Toronto
Project Title:	Fat Reduction and Risk of Benign Breast Disease
Fiscal Year:	1999

DESCRIPTION: This proposed study is to evaluate the feasibility of studying women participating in the Dietary Modification (DM) and the calcium/vitamin D supplementation (CaD) components of the WHI clinical trial (excluding those who are also in the HRT component) to test the hypothesis that adoption of a low-fat dietary pattern is associated with reduced risk of proliferative forms of benign breast disease. Additionally, it is proposed that CaD alone, and in combination with low- fat dietary pattern, will also be associated with reduced risk. Also, it is proposed to conduct a nested case-control analysis of risk factors for proliferative forms of benign breast disease using cases identified in the control arms of the DM and CaD components of the trial. The feasibility study will run for 15 months, including 1 month to generate clinic- specific lists of eligible patients and to train clinics in the study methods, 12 months to conduct the review, and 2 months for data analysis. If the proposed study is feasible, the application predicts that it has the potential to provide insight into the etiology of the putative pre- malignant forms of benign breast disease and might identify an avenue for its prevention.




A Randomized Controlled Trial Of Calcium Plus Vitamin D Supplementation And Risk Of Benign Proliferative Breast Disease
Authors: Rohan T.E. , Negassa A. , Chlebowski R.T. , Ceria-Ulep C.D. , Cochrane B.B. , Lane D.S. , Ginsberg M. , Wassertheil-Smoller S. , Page D.L. .
Source: Breast Cancer Research And Treatment, 2009 Jul; 116(2), p. 339-50.
PMID: 18853250
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Menstrual And Reproductive History, Postmenopausal Hormone Use, And Risk Of Benign Proliferative Epithelial Disorders Of The Breast: A Cohort Study
Authors: Cui Y. , Page D.L. , Lane D.S. , Rohan T.E. .
Source: Breast Cancer Research And Treatment, 2009 Mar; 114(1), p. 113-20.
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Estrogen Plus Progestin And Risk Of Benign Proliferative Breast Disease
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Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2008 Sep; 17(9), p. 2337-43.
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Low-fat Dietary Pattern And Risk Of Benign Proliferative Breast Disease: A Randomized, Controlled Dietary Modification Trial
Authors: Rohan T.E. , Negassa A. , Caan B. , Chlebowski R.T. , Curb J.D. , Ginsberg M. , Lane D.S. , Neuhouser M.L. , Shikany J.M. , Wassertheil-Smoller S. , et al. .
Source: Cancer Prevention Research (philadelphia, Pa.), 2008 Sep; 1(4), p. 275-84.
PMID: 19138971
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Conjugated Equine Estrogen And Risk Of Benign Proliferative Breast Disease: A Randomized Controlled Trial
Authors: Rohan T.E. , Negassa A. , Chlebowski R.T. , Habel L. , McTiernan A. , Ginsberg M. , Wassertheil-Smoller S. , Page D.L. .
Source: Journal Of The National Cancer Institute, 2008-04-16 00:00:00.0; 100(8), p. 563-71.
PMID: 18398105
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Alcohol And Folate Consumption And Risk Of Benign Proliferative Epithelial Disorders Of The Breast
Authors: Cui Y. , Page D.L. , Chlebowski R.T. , Beresford S.A. , Hendrix S.L. , Lane D.S. , Rohan T.E. .
Source: International Journal Of Cancer, 2007-09-15 00:00:00.0; 121(6), p. 1346-51.
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Cigarette Smoking And Risk Of Benign Proliferative Epithelial Disorders Of The Breast In The Women's Health Initiative
Authors: Cui Y. , Page D.L. , Chlebowski R.T. , Hsia J. , Allan Hubbell F. , Johnson K.C. , Rohan T.E. .
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