Grant Number:	5R01CA076031-03 Interpret this number
Primary Investigator:	Piegorsch, Walter
Organization:	University Of South Carolina At Columbia
Project Title:	Low Dose Risk Bounds Via Simultaneous Confidence Bands
Fiscal Year:	1999

DESCRIPTION: (Adapted from investigator's abstract) This project develops and studies statistical confidence bounds useful for low-dose extrapolation in quantitative risk analysis. Application is intended for those risk assessment studies where human or animal data are used to set benchmark or other safe low-dose levels of a toxic stimulus, but where study information is limited to high dose levels of the stimulus. Methods are derived for estimating upper confidence limits on predicted risk and on predicted additional risk for various endpoints, measured on both continuous and discrete scales. From the simultaneous confidence bounds, lower confidence limits on the "effective" stimulus or dose (ED) associated with a particular risk are calculated. An important feature of the simultaneous construction is that any inferences based on inverting the simultaneous confidence bounds apply automatically to inverse bounds on the ED. The methodology extends existing theory on simultaneous prediction bands which applies to mathematical prediction equations useful in quantitative risk assessment/low-dose extrapolation problems. New concepts developed in order to achieve these goals include simultaneous band optimization in low-dose regions of the dose scale, and application to non-normally distributed data and to non-linear, possibly non-monotone dose-response functions. Extensions to simultaneous bounds useful in unlimited inverse prediction for low-dose extrapolation also are considered. An evaluation phase of the project studies the small-sample operating characteristics of the new methodology via Monte Carlo computer calculations, and applies the new methods to existing data for a number of low-dose risk endpoints, including concentration levels of detrimental toxins or toxic metabolites in human or animal subjects, body weight losses in laboratory animals, mutation frequencies in transgenic animals and other transgenic systems, mutational spectra in human or animal/transgenic systems, carcinogenicity rates in laboratory animals, or reproductive capacity limitations in aquatic or other eco-toxicological systems. The new methods fill existing gaps in low-dose risk extrapolation, and have application to a wide variety of data-analytic scenarios in quantitative risk assessment.




Confidence Limits On One-stage Model Parameters In Benchmark Risk Assessment
Authors: Buckley B.E. , Piegorsch W.W. , West R.W. .
Source: Environmental And Ecological Statistics, 2009-03-01 00:00:00.0; 16(1), p. 53-62.
PMID: 20160851
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Bootstrap Methods For Simultaneous Benchmark Analysis With Quantal Response Data
Authors: West R.W. , Nitcheva D.K. , Piegorsch W.W. .
Source: Environmental And Ecological Statistics, 2009-03-01 00:00:00.0; 16(1), p. 63-73.
PMID: 20160852
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Simultaneous Confidence Bands For Abbott-adjusted Quantal Response Models
Authors: Buckley B.E. , Piegorsch W.W. .
Source: Statistical Methodology, 2008 May; 5(3), p. 209-219.
PMID: 19412325
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Communicating The Risks, And The Benefits, Of Nanotechnology
Authors: Piegorsch W.W. , Schuler E. .
Source: International Journal Of Risk Assessment And Management, 2008-01-01 00:00:00.0; 10(1-2), p. 57-69.
PMID: 19823594
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Benchmark Analysis For Quantifying Urban Vulnerability To Terrorist Incidents
Authors: Piegorsch W.W. , Cutter S.L. , Hardisty F. .
Source: Risk Analysis : An Official Publication Of The Society For Risk Analysis, 2007 Dec; 27(6), p. 1411-25.
PMID: 18093043
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On Use Of The Multistage Dose-response Model For Assessing Laboratory Animal Carcinogenicity
Authors: Nitcheva D.K. , Piegorsch W.W. , West R.W. .
Source: Regulatory Toxicology And Pharmacology : Rtp, 2007 Jul; 48(2), p. 135-47.
PMID: 17490794
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Benchmark Analysis: Shopping With Proper Confidence
Authors: Piegorsch,W.W. , West,R.W. .
Source: Risk Analysis : An Official Publication Of The Society For Risk Analysis, 2005 Aug; 25(4), p. 913-20.
PMID: 16268938
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Multiplicity-adjusted Inferences In Risk Assessment: Benchmark Analysis With Quantal Response Data
Authors: Nitcheva D.K. , Piegorsch W.W. , West R.W. , Kodell R.L. .
Source: Biometrics, 2005 Mar; 61(1), p. 277-86.
PMID: 15737104
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Simultaneous Confidence Bounds For Low-dose Risk Assessment With Nonquantal Data
Authors: Piegorsch W.W. , West R.W. , Pan W. , Kodell R.L. .
Source: Journal Of Biopharmaceutical Statistics, 2005; 15(1), p. 17-31.
PMID: 15702602
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Confidence Bands For Low-dose Risk Estimation With Quantal Response Data
Authors: Al-Saidy O.M. , Piegorsch W.W. , West R.W. , Nitcheva D.K. .
Source: Biometrics, 2003 Dec; 59(4), p. 1056-62.
PMID: 14969485
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On A Likelihood-based Goodness-of-fit Test Of The Beta-binomial Model
Authors: Garren S.T. , Smith R.L. , Piegorsch W.W. .
Source: Biometrics, 2000 Sep; 56(3), p. 947-50.
PMID: 10985242
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Estimation And Testing With Overdispersed Proportions Using The Beta-logistic Regression Model Of Heckman And Willis
Authors: Slaton T.L. , Piegorsch W.W. , Durham S.D. .
Source: Biometrics, 2000 Mar; 56(1), p. 125-33.
PMID: 10783786
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