Grant Details
Grant Number: |
5R01CA072919-03 Interpret this number |
Primary Investigator: |
Cohn, Barbara |
Organization: |
Public Health Institute |
Project Title: |
Breast Cancer and Organochlorines |
Fiscal Year: |
1999 |
Abstract
DESCRIPTION: (Adapted from Applicant's Abstract). Recent publication of
the only two prospective studies of the relation of organochlorine exposure
to breast cancer demonstrates need for more research. The findings of the
two prior studies conflict: only one found increased risk associated with
DDE. The only race-specific study found a protective association for
poly-chlorinated biphenyls (PCBs) in Whites, and a suggestion of increase
risk associated with PCBs among Blacks. The proposed study seeks to help
resolve these discrepant findings.
This prospective, nested case-control epidemiological study will be the
first to investigate the relationship of exposure to
1,1-dichloro-2,2'-bis(p-chlorophenyl)-ethylene (DDE) and the PCBs during
pregnancy to breast cancer incidence. The study population is a subset
(N=275 case-control pairs) of the Child Health and Development Studies.
Women enrolled during pregnancy from 1959-1967 and were followed for
subsequent breast cancer by linkage to the California Cancer Registry.
The study has the following aims: 1) assay frozen serum samples obtained
during pregnancy for DDE and PCB; 2) test these hypotheses: a)
organochlorine levels during pregnancy are associated with subsequent breast
cancer' b) birth cohorts exposed to DDE prior to puberty show a stronger
association between DDE and breast cancer than birth cohorts exposed after
puberty; c) associations between organochlorine exposure and breast cancer
are strongest among primigravidas; analyses in primigravidas may be most
sensitive for detection of organochlorine effects because these analyses
will capture both cumulative pubertal exposure and total exposure present
prior to breast differentiation that follow first pregnancy; d) total PCBs
are associated with increased breast cancer risk for Blacks and decreased
risk for Whites; e) some PCB congeners are associated with decreased breast
cancer risk while others are associated with increased risk; and f) race
differences in the composition of total PCBs explain race differences in
associations between total PCBs and breast cancer. The study will be the
first to: 1) measure organochlorine exposure during pregnancy; and 2)
consider timing of exposure in relation to puberty. Puberty and pregnancy
are periods of increased vulnerability to carcinogenesis.
Publications
Exposure To Polychlorinated Biphenyl (pcb) Congeners Measured Shortly After Giving Birth And Subsequent Risk Of Maternal Breast Cancer Before Age 50
Authors: Cohn B.A.
, Terry M.B.
, Plumb M.
, Cirillo P.M.
.
Source: Breast Cancer Research And Treatment, 2012 Nov; 136(1), p. 267-75.
PMID: 23053646
Related Citations
Assaying Organochlorines In Archived Serum For A Large, Long-term Cohort: Implications Of Combining Assay Results From Multiple Laboratories Over Time
Authors: Sholtz R.I.
, McLaughlin K.R.
, Cirillo P.M.
, Petreas M.
, Park J.S.
, Wolff M.S.
, Factor-Litvak P.
, Eskenazi B.
, Krigbaum N.
, Cohn B.A.
.
Source: Environment International, 2011 May; 37(4), p. 709-14.
PMID: 21333355
Related Citations
Developmental And Environmental Origins Of Breast Cancer: Ddt As A Case Study
Authors: Cohn B.A.
.
Source: Reproductive Toxicology (elmsford, N.y.), 2011 Apr; 31(3), p. 302-11.
PMID: 20965245
Related Citations
Ddt And Breast Cancer In Young Women: New Data On The Significance Of Age At Exposure
Authors: Cohn B.A.
, Wolff M.S.
, Cirillo P.M.
, Sholtz R.I.
.
Source: Environmental Health Perspectives, 2007 Oct; 115(10), p. 1406-14.
PMID: 17938728
Related Citations
Placental Characteristics And Reduced Risk Of Maternal Breast Cancer
Authors: Cohn B.A.
, Cirillo P.M.
, Christianson R.E.
, van den Berg B.J.
, Siiteri P.K.
.
Source: Journal Of The National Cancer Institute, 2001-08-01 00:00:00.0; 93(15), p. 1133-40.
PMID: 11481384
Related Citations