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Grant Details

Grant Number: 5R01CA071745-04 Interpret this number
Primary Investigator: Reynolds, Peggy
Organization: Impact Assessment, Inc.
Project Title: Childhood Cancer-Etiologic Clues Using Gis
Fiscal Year: 1999
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Abstract

DESCRIPTION: (Adapted from Investigator's Abstract) Little is known about the causes of childhood cancers, but there has been increasing public concern that environmental toxicants may contribute to the risk of developing this heterogeneous group of diseases. California, with the largest population-based cancer registry in the world and with a unique wealth of environmental exposure databases, provides an unusual opportunity to evaluate these rare malignancies in geographically and socio-culturally diverse settings. The proposed study seeks to evaluate the first five years (1988-1992) of California statewide population-based childhood cancer incidence data in conjunction with geographic indicators of the socio-cultural diversity of the state, and in conjunction with well characterized and temporally relevant detailed statewide environmental exposure information, to explore some of the more prominent current hypotheses about environmental influences on the etiology of these diseases. This work is designed to build on the California Department of Health Services/Environmental Health Investigation Branch's long history of work in the study of childhood cancer "clusters", in characterizing environmental exposures of concern to human health, and in developing geographic information system (GIS) analysis strategies to complement epidemiologic research efforts. Specific aims are targeted at an evaluation of: - How childhood cancer rates vary with geographically defined environmental emissions or exposures; - How childhood cancer rates vary by demographic characteristics of the population; and - The independent effects of environmental or demographic risk associations. The proposed research is designed to identify risk associations worthy of more in-depth investigation, while minimizing some of the limitations of ecologic research. The investigators state that the availability of unique existing databases to characterize both exposure and disease outcome in California's large and heterogeneous population offer an opportunity to integrate epidemiologic, environmental exposure, and GIS analytic strategies to enhance our understanding of factors influencing a group of rare diseases which constitute a major cause of death in children.

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Publications

Birth characteristics and childhood carcinomas.
Authors: Johnson K.J. , Carozza S.E. , Chow E.J. , Fox E.E. , Horel S. , McLaughlin C.C. , Mueller B.A. , Puumala S.E. , Reynolds P. , Von Behren J. , et al. .
Source: British journal of cancer, 2011-10-25; 105(9), p. 1396-401.
EPub date: 2011-09-13.
PMID: 21915125
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Birth order and risk of childhood cancer: a pooled analysis from five US States.
Authors: Von Behren J. , Spector L.G. , Mueller B.A. , Carozza S.E. , Chow E.J. , Fox E.E. , Horel S. , Johnson K.J. , McLaughlin C. , Puumala S.E. , et al. .
Source: International journal of cancer, 2011-06-01; 128(11), p. 2709-16.
EPub date: 2010-10-08.
PMID: 20715170
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Childhood cancer in relation to parental race and ethnicity: a 5-state pooled analysis.
Authors: Chow E.J. , Puumala S.E. , Mueller B.A. , Carozza S.E. , Fox E.E. , Horel S. , Johnson K.J. , McLaughlin C.C. , Reynolds P. , Von Behren J. , et al. .
Source: Cancer, 2010-06-15; 116(12), p. 3045-53.
PMID: 20564410
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Cancer risk among children with very low birth weights.
Authors: Spector L.G. , Puumala S.E. , Carozza S.E. , Chow E.J. , Fox E.E. , Horel S. , Johnson K.J. , McLaughlin C.C. , Reynolds P. , Behren J.V. , et al. .
Source: Pediatrics, 2009 Jul; 124(1), p. 96-104.
PMID: 19564288
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Parental age and risk of childhood cancer: a pooled analysis.
Authors: Johnson K.J. , Carozza S.E. , Chow E.J. , Fox E.E. , Horel S. , McLaughlin C.C. , Mueller B.A. , Puumala S.E. , Reynolds P. , Von Behren J. , et al. .
Source: Epidemiology (Cambridge, Mass.), 2009 Jul; 20(4), p. 475-83.
PMID: 19373093
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Childhood cancer among twins and higher order multiples.
Authors: Puumala S.E. , Carozza S.E. , Chow E.J. , Fox E.E. , Horel S. , Johnson K.J. , McLaughlin C. , Mueller B.A. , Reynolds P. , Von Behren J. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009 Jan; 18(1), p. 162-8.
PMID: 19124494
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Linkage of the California Pesticide Use Reporting Database with spatial land use data for exposure assessment.
Authors: Nuckols J.R. , Gunier R.B. , Riggs P. , Miller R. , Reynolds P. , Ward M.H. .
Source: Environmental health perspectives, 2007 May; 115(5), p. 684-9.
EPub date: 2007-01-04.
PMID: 17520053
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Birth characteristics and risk of neuroblastoma in young children.
Authors: Urayama K.Y. , Von Behren J. , Reynolds P. .
Source: American journal of epidemiology, 2007-03-01; 165(5), p. 486-95.
EPub date: 2006-12-12.
PMID: 17164463
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Agricultural pesticides and lymphoproliferative childhood cancer in California.
Authors: Reynolds P. , Von Behren J. , Gunier R. , Goldberg D.E. , Hertz A. .
Source: Scandinavian journal of work, environment & health, 2005; 31 Suppl 1, p. 46-54; discussion 5-7.
PMID: 16190149
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Agricultural pesticide use and childhood cancer in California.
Authors: Reynolds P. , Von Behren J. , Gunier R.B. , Goldberg D.E. , Harnly M. , Hertz A. .
Source: Epidemiology (Cambridge, Mass.), 2005 Jan; 16(1), p. 93-100.
PMID: 15613951
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Birth characteristics and hepatoblastoma risk in young children.
Authors: Reynolds P. , Urayama K.Y. , Von Behren J. , Feusner J. .
Source: Cancer, 2004-03-01; 100(5), p. 1070-6.
PMID: 14983504
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Residential exposure to traffic in California and childhood cancer.
Authors: Reynolds P. , Von Behren J. , Gunier R.B. , Goldberg D.E. , Hertz A. .
Source: Epidemiology (Cambridge, Mass.), 2004 Jan; 15(1), p. 6-12.
PMID: 14712141
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Birth characteristics and brain cancers in young children.
Authors: Von Behren J. , Reynolds P. .
Source: International journal of epidemiology, 2003 Apr; 32(2), p. 248-56.
PMID: 12714545
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Childhood cancer incidence rates and hazardous air pollutants in California: an exploratory analysis.
Authors: Reynolds P. , Von Behren J. , Gunier R.B. , Goldberg D.E. , Hertz A. , Smith D.F. .
Source: Environmental health perspectives, 2003 Apr; 111(4), p. 663-8.
PMID: 12676632
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Traffic patterns and childhood cancer incidence rates in California, United States.
Authors: Reynolds P. , Von Behren J. , Gunier R.B. , Goldberg D.E. , Hertz A. , Smith D. .
Source: Cancer causes & control : CCC, 2002 Sep; 13(7), p. 665-73.
PMID: 12296514
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Birth characteristics and leukemia in young children.
Authors: Reynolds P. , Von Behren J. , Elkin E.P. .
Source: American journal of epidemiology, 2002-04-01; 155(7), p. 603-13.
PMID: 11914187
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Childhood cancer and agricultural pesticide use: an ecologic study in California.
Authors: Reynolds P. , Von Behren J. , Gunier R.B. , Goldberg D.E. , Hertz A. , Harnly M.E. .
Source: Environmental health perspectives, 2002 Mar; 110(3), p. 319-24.
PMID: 11882484
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Agricultural pesticide use in California: pesticide prioritization, use densities, and population distributions for a childhood cancer study.
Authors: Gunier R.B. , Harnly M.E. , Reynolds P. , Hertz A. , Von Behren J. .
Source: Environmental health perspectives, 2001 Oct; 109(10), p. 1071-8.
PMID: 11689348
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A case-control pilot study of traffic exposures and early childhood leukemia using a geographic information system.
Authors: Reynolds P. , Elkin E. , Scalf R. , Von Behren J. , Neutra R.R. .
Source: Bioelectromagnetics, 2001; Suppl 5, p. S58-68.
PMID: 11170118
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