Grant Number:	5R01CA068615-04 Interpret this number
Primary Investigator:	Lamb, Dolores
Organization:	Baylor College Of Medicine
Project Title:	Androgen Receptor Mutations in Advanced Prostate Cancer
Fiscal Year:	1999

DESCRIPTION: The long range goal of this project is to determine whether androgen receptor (AR) mutations/polymorphisms can be used as a functional biomarker of prostate cancer development or progression. The applicant theorized that androgen independent tumors have escaped androgen control because the receptor has become functionally activated because of gene mutation. Her preliminary studies have shown that androgen receptor mutations frequently occur in advanced prostate cancer, the proposal seeks support to define whether androgen receptor mutations/polymorphisms can be used as a functional biomarker of prostate cancer development or progression by defining the incidence and type of mutations associated with prostate cancer. It is imperative that the functional significance of these mutations be defined. These studies will define the significance of androgen receptor mutations in the development/progression of prostate cancer and validate their application as biomarkers.




Molecular Analysis Of The Androgen Receptor In Ten Prostate Cancer Specimens Obtained Before And After Androgen Ablation
Authors: Lamb D.J. , Puxeddu E. , Malik N. , Stenoien D.L. , Nigam R. , Saleh G.Y. , Mancini M. , Weigel N.L. , Marcelli M. .
Source: Journal Of Andrology, 2003 Mar-Apr; 24(2), p. 215-25.
PMID: 12634308
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A Novel Androgen Receptor Mutant, A748t, Exhibits Hormone Concentration-dependent Defects In Nuclear Accumulation And Activity Despite Normal Hormone-binding Affinity
Authors: James A.J. , Agoulnik I.U. , Harris J.M. , Buchanan G. , Tilley W.D. , Marcelli M. , Lamb D.J. , Weigel N.L. .
Source: Molecular Endocrinology (baltimore, Md.), 2002 Dec; 16(12), p. 2692-705.
PMID: 12456791
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Significance Of The Polyglutamine Tract Polymorphism In The Androgen Receptor
Authors: Casella R. , Maduro M.R. , Lipshultz L.I. , Lamb D.J. .
Source: Urology, 2001 Nov; 58(5), p. 651-6.
PMID: 11711330
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Androgen Receptor Mutations In Prostate Cancer
Authors: Marcelli M. , Ittmann M. , Mariani S. , Sutherland R. , Nigam R. , Murthy L. , Zhao Y. , DiConcini D. , Puxeddu E. , Esen A. , et al. .
Source: Cancer Research, 2000-02-15 00:00:00.0; 60(4), p. 944-9.
PMID: 10706109
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A C619y Mutation In The Human Androgen Receptor Causes Inactivation And Mislocalization Of The Receptor With Concomitant Sequestration Of Src-1 (steroid Receptor Coactivator 1)
Authors: Nazareth L.V. , Stenoien D.L. , Bingman W.E. , James A.J. , Wu C. , Zhang Y. , Edwards D.P. , Mancini M. , Marcelli M. , Lamb D.J. , et al. .
Source: Molecular Endocrinology (baltimore, Md.), 1999 Dec; 13(12), p. 2065-75.
PMID: 10598582
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Hormonal Signaling In Prostatic Hyperplasia And Neoplasia
Authors: Marcelli M. , Cunningham G.R. .
Source: The Journal Of Clinical Endocrinology And Metabolism, 1999 Oct; 84(10), p. 3463-8.
PMID: 10522981
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Polyglutamine-expanded Androgen Receptors Form Aggregates That Sequester Heat Shock Proteins, Proteasome Components And Src-1, And Are Suppressed By The Hdj-2 Chaperone
Authors: Stenoien D.L. , Cummings C.J. , Adams H.P. , Mancini M.G. , Patel K. , DeMartino G.N. , Marcelli M. , Weigel N.L. , Mancini M.A. .
Source: Human Molecular Genetics, 1999 May; 8(5), p. 731-41.
PMID: 10196362
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Progression Of Metastatic Human Prostate Cancer To Androgen Independence In Immunodeficient Scid Mice
Authors: Klein K.A. , Reiter R.E. , Redula J. , Moradi H. , Zhu X.L. , Brothman A.R. , Lamb D.J. , Marcelli M. , Belldegrun A. , Witte O.N. , et al. .
Source: Nature Medicine, 1997 Apr; 3(4), p. 402-8.
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