A population-based case-control study to examine the effects of
occupational exposures on the subsequent risk of prostate cancer is
proposed. Cases of prostate cancer (N approx. 1,500) who are; 1) 50 to 74
years of age at diagnosis, 2) newly diagnosed during a two year period, 3)
resident in Wayne County (which includes the city of Detroit) at the time
of diagnosis, 4) living at the time of identification, and 5) in possession
of a telephone at the time of diagnosis, will be identified through the
Metropolitan Detroit Cancer Surveillance System (a participant in the
Surveillance, Epidemiology, and End Results [SEER] Program of the National
Cancer Institute). Early identification of cases will be accomplished via
a rapid reporting system which is already in place within the registry.
Controls will be chosen by random digit dialing and will be frequency
matched to the cases by age (in five year groups) and race (white, black,
other) in a 1:1 control to case ratio. In-person interviews will be
conducted by trained interviewers at a time and location of the study
subject's choice. An intensive method utilizing expert review of
occupational information will be used to ascertain lifelong occupational
exposures for each study subject. This approach, developed by Dr.
Siemiatycki in Montreal, is based on information supplied by the subject in
response to a general occupational questionnaire and detailed
questionnaires for specific occupations. The highly industrial setting of
the Detroit metropolitan area provides a unique opportunity to explore
occupational exposures in substantial detail. In addition to the case
control data to be derived from this study, another important product will
be the development of a group of professionals in the United States who are
skilled in the "technology" of the occupational exposure assessment
methods pioneered by Dr. Siemiatycki's group in Montreal.
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