||5R01CA068045-03 Interpret this number
||Genetic/Epidemiology of Breast/Prostate Cancer
DESCRIPTION (Adapted from the Investigator's Abstract): There is increasing
recognition that prostate cancer and breast cancer demonstrate significant
clustering in some families. What is not known, however, is whether this
observation is due to coincidence, common environment, or are flection of
inherited susceptibility. The purpose of the proposed research is to
investigate the genetic epidemiology of breast-prostate cancer in a nested
case-control family study within an ongoing cohort study of 544 highly
characterized 4- and 5- generation families initially ascertained through a
proband with breast cancer at the University of Minnesota between 1944 and
1952 (R01 CA55747, T. Sellers, P.I.). From this larger cohort, the
investigators propose to select 50 case families in which at least 4 women
have developed breast or ovarian cancer, and two control groups: a) control
families in which only the original proband developed breast cancer and b)
men who have married into the case families. The occurrence of prostate
cancer will be determined among a) brothers, sons, nephews, and grandsons of
the case and control probands, and b) the spouses of first- and second-
degree female family members in the case families. Data will be collected
by telephone interview and mailed questionnaires to assess those
environmental and lifestyle exposures that might promote the clustering of
breast and prostate cancer within these families for non-genetic reasons.
Detailed analyses of family history will be performed to see if there is an
excess occurrence of prostate cancer in the case families compared with the
two control groups. Analyses of individual family members will be performed
to determine if any observed excesses of prostate cancer can be attributed
to measure non-genetic risk factors. Complex segregation analysis,
incorporating environmental covariates, will be performed to determine
whether the familial aggregation of breast and prostate is consistent with a
Mendelian pattern of inheritance. This will be performed using the REGTL
software program in Statistical Analysis for Genetic Epidemiology (SAGE) and
Pedigree Analysis Package (PAP). Finally, blood samples will be collected
as a source of genomic DNA for future studies to explore the role of several
candidate genes on the susceptibility to these hormone-dependent
Evaluation of familial clustering of breast and prostate cancer in the Minnesota Breast Cancer Family Study.
, Cerhan J.R.
, Vierkant R.A.
, Therneau T.M.
, Cheville J.C.
, Tindall D.J.
, Sellers T.A.
Cancer detection and prevention, 2003; 27(1), p. 30-6.