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Grant Details

Grant Number: 5R01CA063021-06 Interpret this number
Primary Investigator: Stellman, Steven
Organization: Institute For Cancer Prevention
Project Title: Epidemiology of Breast Cancer on Long Island
Fiscal Year: 1999
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Abstract

DESCRIPTION: There are conflicting data regarding the associations between serum levels of OCCs (e.g., DDE) and of PCB with the risk of developing breast cancer. The application is intended to complete a previously-supported, case-control study to determine whether the levels of these substances is elevated in the serum and adipose tissue of breast cancer cases, diagnosed on Long Island, compared to controls from the same location (benign breast disease and surgical controls). To date, 338 case patients, 418 women with benign breast disease and 197 surgical controls have been interviewed, and 819 adipose samples and 896 serum aliquots collected. One fourth of these samples have been analyzed and the preliminary results show that DDE and possibly certain PCB congeners are associated with increased risk of breast cancer. The future plan is to continue in order to: 1) complete assays on the remaining 3/4 of the samples; 2) determine the lipid-adjusted serum concentrations of OCCs and their partition between serum and adipose tissue; 3) correlate OCC levels with age, body mass, and location in order to adjust breast cancer risk for these confounders; 4) determine whether adjusted risk estimates differ by estrogen receptor status of the tumors; 5) correlate OCC levels with recurrence and mortality from breast cancer via follow-up cases; 6) study short term (1-3 yr.) stability of serum OCC and PCB levels and the impact of treatment on these levels; 7) estimate breast cancer risk, utilizing different classifications for PCB congeners; and 8) determine whether OCC-related risk of breast cancer can be correlated with degrees of atypia of the benign breast biopsy controls, using pathologic reviews of samples from over 400 patients.

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Publications

Imputation method for lifetime exposure assessment in air pollution epidemiologic studies.
Authors: Beyea J. , Stellman S.D. , Teitelbaum S. , Mordukhovich I. , Gammon M.D. .
Source: Environmental health : a global access science source, 2013-08-07; 12, p. 62.
EPub date: 2013-08-07.
PMID: 23919666
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Self-reported exposure to pesticides in residential settings and risk of breast cancer: a case-control study.
Authors: Farooq U. , Joshi M. , Nookala V. , Cheriyath P. , Fischman D. , Graber N.J. , Stellman S.D. , Muscat J. .
Source: Environmental health : a global access science source, 2010-06-25; 9, p. 30.
EPub date: 2010-06-25.
PMID: 20579356
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Airborne emissions from 1961 to 2004 of benzo[a]pyrene from U.S. vehicles per km of travel based on tunnel studies.
Authors: Beyea J. , Stellman S.D. , Hatch M. , Gammon M.D. .
Source: Environmental science & technology, 2008-10-01; 42(19), p. 7315-20.
PMID: 18939564
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Validation and calibration of a model used to reconstruct historical exposure to polycyclic aromatic hydrocarbons for use in epidemiologic studies.
Authors: Beyea J. , Hatch M. , Stellman S.D. , Santella R.M. , Teitelbaum S.L. , Prokopczyk B. , Camann D. , Gammon M.D. .
Source: Environmental health perspectives, 2006 Jul; 114(7), p. 1053-8.
PMID: 16835058
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Adipose concentrations of organochlorine compounds and breast cancer recurrence in Long Island, New York.
Authors: Muscat J.E. , Britton J.A. , Djordjevic M.V. , Citron M.L. , Kemeny M. , Busch-Devereaux E. , Pittman B. , Stellman S.D. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2003 Dec; 12(12), p. 1474-8.
PMID: 14693740
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Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York.
Authors: Stellman S.D. , Djordjevic M.V. , Britton J.A. , Muscat J.E. , Citron M.L. , Kemeny M. , Busch E. , Gong L. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000 Nov; 9(11), p. 1241-9.
PMID: 11097233
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Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York.
Authors: Stellman S.D. , Djordjevic M.V. , Muscat J.E. , Gong L. , Bernstein D. , Citron M.L. , White A. , Kemeny M. , Busch E. , Nafziger A.N. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1998 Jun; 7(6), p. 489-96.
PMID: 9641493
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Tobacco smoking, cancer and social class.
Authors: Stellman S.D. , Resnicow K. .
Source: IARC scientific publications, 1997; (138), p. 229-50.
PMID: 9353667
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Breast cancer and Women & Health.
Authors: Garfinkel L. , Stellman S.D. .
Source: Women & health, 1997; 26(1), p. 1-5.
PMID: 9311096
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Cancer and the workplace.
Authors: Stellman J.M. , Stellman S.D. .
Source: CA: a cancer journal for clinicians, 1996 Mar-Apr; 46(2), p. 70-92.
PMID: 8624799
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Proportional mortality ratios among Korean immigrants to New York City, 1986-1990.
Authors: Stellman S.D. .
Source: Yonsei medical journal, 1996 Feb; 37(1), p. 31-7.
PMID: 8967107
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Assessment of chlorinated pesticides and polychlorinated biphenyls in adipose breast tissue using a supercritical fluid extraction method.
Authors: Djordjevic M.V. , Hoffmann D. , Fan J. , Prokopczyk B. , Citron M.L. , Stellman S.D. .
Source: Carcinogenesis, 1994 Nov; 15(11), p. 2581-5.
PMID: 7955109
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