Grant Number:	5R01CA039929-15 Interpret this number
Primary Investigator:	Harrington, David
Organization:	Dana-Farber Cancer Institute
Project Title:	Nonparametric Statistical Test for Censored Data
Fiscal Year:	1999

DESCRIPTION (Adapted from applicant's abstract): The main theme of this project is the investigation of methodology for the censored or missing data that commonly arises in clinical trials and cohort studies in cancer research. More specifically, we will investigate: 1. Methods for analyzing the cost or resource utilization in cancer studies with incomplete follow-up. 2. Adaptive inference based on families of either regression models or rank tests when a most efficient model cannot be specified in advance. 3. Models that adjust for missing data or partial information in either the cause of failure in right censored data or in longitudinally measured response data, such as in quality of life scores. 4. Group sequential designs for monitoring survival probabilities, as opposed to hazard ratios, in cancer clinical trials.




Iterative Partial Least Squares With Right-censored Data Analysis: A Comparison To Other Dimension Reduction Techniques
Authors: Huang J. , Harrington D. .
Source: Biometrics, 2005 Mar; 61(1), p. 17-24.
PMID: 15737074
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Adaptive Test For Testing The Difference In Survival Distributions
Authors: Pecková M. , Fleming T.R. .
Source: Lifetime Data Analysis, 2003 Sep; 9(3), p. 223-38.
PMID: 14649843
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Penalized Partial Likelihood Regression For Right-censored Data With Bootstrap Selection Of The Penalty Parameter
Authors: Huang J. , Harrington D. .
Source: Biometrics, 2002 Dec; 58(4), p. 781-91.
PMID: 12495132
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A Semiparametric Estimate Of Treatment Effects With Censored Data
Authors: Xu R. , Harrington D.P. .
Source: Biometrics, 2001 Sep; 57(3), p. 875-85.
PMID: 11550940
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Omnibus Tests Of The Martingale Assumption In The Analysis Of Recurrent Failure Time Data
Authors: Jones C.L. , Harrington D.P. .
Source: Lifetime Data Analysis, 2001 Jun; 7(2), p. 157-71.
PMID: 11458655
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Survival Analysis With Time-varying Relative Risks: A Tree-based Approach
Authors: Xu R. , Adak S. .
Source: Methods Of Information In Medicine, 2001 May; 40(2), p. 141-7.
PMID: 11424300
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Sample Size Calculations For The Two-sample Problem Using The Multiplicative Intensity Model
Authors: Bernardo M.V. , Harrington D.P. .
Source: Statistics In Medicine, 2001-02-28 00:00:00.0; 20(4), p. 557-79.
PMID: 11223901
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Group sequential designs for cure rate models with early stopping in favour of the null hypothesis.
Authors: Patricia Bernardo M.V. , Ibrahim J.G. .
Source: Statistics In Medicine, 2000-11-30 00:00:00.0; 19(22), p. 3023-35.
PMID: 11113940
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Assessing The Sensitivity Of Regression Results To Unmeasured Confounders In Observational Studies
Authors: Lin D.Y. , Psaty B.M. , Kronmal R.A. .
Source: Biometrics, 1998 Sep; 54(3), p. 948-63.
PMID: 9750244
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On Tests For Group Variation With A Small To Moderate Number Of Groups
Authors: Gray R.J. .
Source: Lifetime Data Analysis, 1998; 4(2), p. 139-48.
PMID: 9658772
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Diagnostic Plots To Reveal Functional Form For Covariates In Multiplicative Intensity Models
Authors: Grambsch P.M. , Therneau T.M. , Fleming T.R. .
Source: Biometrics, 1995 Dec; 51(4), p. 1469-82.
PMID: 8589234
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Defining, Identifying, And Studying High-risk Families: Developing Cohorts For Epidemiologic Study
Authors: Harrington D.P. , Whittemore A.S. .
Source: Journal Of The National Cancer Institute. Monographs, 1995; (17), p. 91-4.
PMID: 8573463
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Spline-based tests in survival analysis.
Authors: Gray R.J. .
Source: Biometrics, 1994 Sep; 50(3), p. 640-52.
PMID: 7981391
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Surrogate And Auxiliary Endpoints In Clinical Trials, With Potential Applications In Cancer And Aids Research
Authors: Fleming T.R. , Prentice R.L. , Pepe M.S. , Glidden D. .
Source: Statistics In Medicine, 1994-05-15 00:00:00.0; 13(9), p. 955-68.
PMID: 8047747
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A Bayesian analysis of institutional effects in a multicenter cancer clinical trial.
Authors: Gray R.J. .
Source: Biometrics, 1994 Mar; 50(1), p. 244-53.
PMID: 8086608
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Kaplan-meier, Marginal Or Conditional Probability Curves In Summarizing Competing Risks Failure Time Data?
Authors: Pepe M.S. , Mori M. .
Source: Statistics In Medicine, 1993-04-30 00:00:00.0; 12(8), p. 737-51.
PMID: 8516591
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Data Monitoring Committees And Capturing Relevant Information Of High Quality
Authors: Fleming T.R. .
Source: Statistics In Medicine, 1993 Mar; 12(5-6), p. 565-70; discussion 571-3.
PMID: 8493432
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Cost-efficient study designs for binary response data with Gaussian covariate measurement error.
Authors: Spiegelman D. , Gray R. .
Source: Biometrics, 1991 Sep; 47(3), p. 851-69.
PMID: 1789885
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Some Diagnostic Methods For Cox Regression Models Through Hazard Smoothing
Authors: Gray R.J. .
Source: Biometrics, 1990 Mar; 46(1), p. 93-102.
PMID: 2190638
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A Linear Rank Test For Use When The Main Interest Is In Differences In Cure Rates
Authors: Gray R.J. , Tsiatis A.A. .
Source: Biometrics, 1989 Sep; 45(3), p. 899-904.
PMID: 2790128
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Efficiency Of Balanced Treatment Allocation For Survival Analysis
Authors: Kalish L.A. , Harrington D.P. .
Source: Biometrics, 1988 Sep; 44(3), p. 815-21.
PMID: 3203130
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