Skip to main content
Grant Details

Grant Number: 1R03CA080648-01 Interpret this number
Primary Investigator: Lampe, Johanna
Organization: Fred Hutchinson Cancer Research Center
Project Title: Development and Evaluation of a Soyfood Questionnaire
Fiscal Year: 1998


DESCRIPTION: (Applicant's Description) In recent years, numerous studies have suggested that the consumption of soybeans and soybean-containing foods may contribute to the lower rates of breast, colon, and prostate cancer in Asia as compared to the U.S. and other Westernized countries. Unfortunately, there is currently no available or tested dietary assessment instrument for the measurement of soyfood consumption and/or isoflavone intake, especially in populations consuming a Western diet. The objective of this proposed study is to develop and validate a soyfood questionnaire that is appropriate for use in epidemiologic studies of diet and health. The specific aims of this proposal are: 1) To conduct a systematic survey of soyfoods available in a large, metropolitan area in the U.S., and use that information to develop a soyfood questionnaire; 2) To validate the soy questionnaire against plasma isoflavone (genistein and daidzein) concentrations; 3) To examine the association between plasma isoflavone concentrations and soy intake as measured by the soyfood questionnaire compared to the Women's Health Initiative Food Frequency Questionnaire (FFQ), which contains only two questions on soyfoods (soy milk and tofu). We propose to develop a soyfood questionnaire and test its validity. Specifically, we will assess the bias and precision of genistein and daidzein intake estimated from a soyfood questionnaire with the plasma levels of these compounds. This study takes advantage of already collected data and requests resources needed to: 1) collect data on additional individuals; 2) conduct a more systematic study of soyfood availability; 3) document our nutrient database; and 4) measure plasma genistein and daidzein concentrations. A total sample of 63 men and 63 women will complete soyfood questionnaires, a FFQ, and provide fasting blood samples. This work fills an important methodologic gap in epidemiologic research by providing investigators with a validated instrument for monitoring soyfood and isoflavone exposure in population-based studies in the United States.


Selected nutritional biomarkers predict diet quality.
Authors: Neuhouser M.L. , Patterson R.E. , King I.B. , Horner N.K. , Lampe J.W. .
Source: Public health nutrition, 2003 Oct; 6(7), p. 703-9.
PMID: 14552672
Related Citations

Isoflavonoid and lignan phytoestrogens as dietary biomarkers.
Authors: Lampe J.W. .
Source: The Journal of nutrition, 2003 Mar; 133 Suppl 3, p. 956S-964S.
PMID: 12612182
Related Citations

Validation of a soy food-frequency questionnaire and evaluation of correlates of plasma isoflavone concentrations in postmenopausal women.
Authors: Frankenfeld C.L. , Patterson R.E. , Horner N.K. , Neuhouser M.L. , Skor H.E. , Kalhorn T.F. , Howald W.N. , Lampe J.W. .
Source: The American journal of clinical nutrition, 2003 Mar; 77(3), p. 674-80.
PMID: 12600860
Related Citations

Validation of a soy food frequency questionnaire with plasma concentrations of isoflavones in US adults.
Authors: Frankenfeld C.L. , Patterson R.E. , Kalhorn T.F. , Skor H.E. , Howald W.N. , Lampe J.W. .
Source: Journal of the American Dietetic Association, 2002 Oct; 102(10), p. 1407-13.
PMID: 12396157
Related Citations

Participant characteristics associated with errors in self-reported energy intake from the Women's Health Initiative food-frequency questionnaire.
Authors: Horner N.K. , Patterson R.E. , Neuhouser M.L. , Lampe J.W. , Beresford S.A. , Prentice R.L. .
Source: The American journal of clinical nutrition, 2002 Oct; 76(4), p. 766-73.
PMID: 12324289
Related Citations

Dietary determinants of plasma enterolactone.
Authors: Horner N.K. , Kristal A.R. , Prunty J. , Skor H.E. , Potter J.D. , Lampe J.W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002 Jan; 11(1), p. 121-6.
PMID: 11815409
Related Citations

Indirect calorimetry protocol development for measuring resting metabolic rate as a component of total energy expenditure in free-living postmenopausal women.
Authors: Horner N.K. , Lampe J.W. , Patterson R.E. , Neuhouser M.L. , Beresford S.A. , Prentice R.L. .
Source: The Journal of nutrition, 2001 Aug; 131(8), p. 2215-8.
PMID: 11481420
Related Citations

Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness.
Authors: Horner N.K. , Lampe J.W. .
Source: Journal of the American Dietetic Association, 2000 Nov; 100(11), p. 1368-80.
PMID: 11103660
Related Citations

Back to Top