Grant Details
Grant Number: |
1R03CA080648-01 Interpret this number |
Primary Investigator: |
Lampe, Johanna |
Organization: |
Fred Hutchinson Cancer Research Center |
Project Title: |
Development and Evaluation of a Soyfood Questionnaire |
Fiscal Year: |
1998 |
Abstract
DESCRIPTION: (Applicant's Description) In recent years, numerous studies
have suggested that the consumption of soybeans and soybean-containing foods
may contribute to the lower rates of breast, colon, and prostate cancer in
Asia as compared to the U.S. and other Westernized countries.
Unfortunately, there is currently no available or tested dietary assessment
instrument for the measurement of soyfood consumption and/or isoflavone
intake, especially in populations consuming a Western diet.
The objective of this proposed study is to develop and validate a soyfood
questionnaire that is appropriate for use in epidemiologic studies of diet
and health. The specific aims of this proposal are: 1) To conduct a
systematic survey of soyfoods available in a large, metropolitan area in the
U.S., and use that information to develop a soyfood questionnaire; 2) To
validate the soy questionnaire against plasma isoflavone (genistein and
daidzein) concentrations; 3) To examine the association between plasma
isoflavone concentrations and soy intake as measured by the soyfood
questionnaire compared to the Women's Health Initiative Food Frequency
Questionnaire (FFQ), which contains only two questions on soyfoods (soy milk
and tofu).
We propose to develop a soyfood questionnaire and test its validity.
Specifically, we will assess the bias and precision of genistein and
daidzein intake estimated from a soyfood questionnaire with the plasma
levels of these compounds. This study takes advantage of already collected
data and requests resources needed to: 1) collect data on additional
individuals; 2) conduct a more systematic study of soyfood availability; 3)
document our nutrient database; and 4) measure plasma genistein and daidzein
concentrations. A total sample of 63 men and 63 women will complete soyfood
questionnaires, a FFQ, and provide fasting blood samples.
This work fills an important methodologic gap in epidemiologic research by
providing investigators with a validated instrument for monitoring soyfood
and isoflavone exposure in population-based studies in the United States.
Publications
Selected Nutritional Biomarkers Predict Diet Quality
Authors: Neuhouser M.L.
, Patterson R.E.
, King I.B.
, Horner N.K.
, Lampe J.W.
.
Source: Public Health Nutrition, 2003 Oct; 6(7), p. 703-9.
PMID: 14552672
Related Citations
Validation Of A Soy Food-frequency Questionnaire And Evaluation Of Correlates Of Plasma Isoflavone Concentrations In Postmenopausal Women
Authors: Frankenfeld C.L.
, Patterson R.E.
, Horner N.K.
, Neuhouser M.L.
, Skor H.E.
, Kalhorn T.F.
, Howald W.N.
, Lampe J.W.
.
Source: The American Journal Of Clinical Nutrition, 2003 Mar; 77(3), p. 674-80.
PMID: 12600860
Related Citations
Isoflavonoid And Lignan Phytoestrogens As Dietary Biomarkers
Authors: Lampe J.W.
.
Source: The Journal Of Nutrition, 2003 Mar; 133 Suppl 3, p. 956S-964S.
PMID: 12612182
Related Citations
Participant Characteristics Associated With Errors In Self-reported Energy Intake From The Women's Health Initiative Food-frequency Questionnaire
Authors: Horner N.K.
, Patterson R.E.
, Neuhouser M.L.
, Lampe J.W.
, Beresford S.A.
, Prentice R.L.
.
Source: The American Journal Of Clinical Nutrition, 2002 Oct; 76(4), p. 766-73.
PMID: 12324289
Related Citations
Validation Of A Soy Food Frequency Questionnaire With Plasma Concentrations Of Isoflavones In Us Adults
Authors: Frankenfeld C.L.
, Patterson R.E.
, Kalhorn T.F.
, Skor H.E.
, Howald W.N.
, Lampe J.W.
.
Source: Journal Of The American Dietetic Association, 2002 Oct; 102(10), p. 1407-13.
PMID: 12396157
Related Citations
Dietary Determinants Of Plasma Enterolactone
Authors: Horner N.K.
, Kristal A.R.
, Prunty J.
, Skor H.E.
, Potter J.D.
, Lampe J.W.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2002 Jan; 11(1), p. 121-6.
PMID: 11815409
Related Citations
Indirect Calorimetry Protocol Development For Measuring Resting Metabolic Rate As A Component Of Total Energy Expenditure In Free-living Postmenopausal Women
Authors: Horner N.K.
, Lampe J.W.
, Patterson R.E.
, Neuhouser M.L.
, Beresford S.A.
, Prentice R.L.
.
Source: The Journal Of Nutrition, 2001 Aug; 131(8), p. 2215-8.
PMID: 11481420
Related Citations
Potential Mechanisms Of Diet Therapy For Fibrocystic Breast Conditions Show Inadequate Evidence Of Effectiveness
Authors: Horner N.K.
, Lampe J.W.
.
Source: Journal Of The American Dietetic Association, 2000 Nov; 100(11), p. 1368-80.
PMID: 11103660
Related Citations