||5R03CA077954-02 Interpret this number
||Helicobacter Pylori Malnutrition and Gastric Cancer
Our objectives are to better understand the role of Helicobacter pylori
infection on the risk of gastric cancer, and its interaction with genetic
susceptibility, high intake of salt or salty food, smoking, green tea
drinking, and family history of cancer in the development of gastric cancer.
We will make use of available data and blood sample from a population-based
case-control study in order to establish the synergic effects between H.
Pylori, GST M1 and T1, smoking, other environmental and familial factors.
We choose Yangzhong County, one of areas with the highest incidence and
mortality of gastric cancer in the world, as a study base. With a
collaborative effort, all 733 study subjects (133 incident cases with
gastric cancer, 166 cases with chronic gastritis, and 434 population
controls) were interviewed by a standard questionnaire in Yangzhong County,
and blood specimens were available in 539 subjects. The epidemiologic data
and blood specimens were stored at our Cancer Center. We propose that H.
pylori infection may be involved in the early stage of gastric
carcinogenesis and this process may be modulated by genetic susceptibility,
smoking, and other nutritional and environmental and familial factors. We
will measure serum IgG antibody against H. pylori infection in order to
evaluate the relationships between H. pylori infection and chronic gastritis
as well as stomach cancer. We will evaluate the association between the
risk of gastric cancer and genetic susceptibility, environmental and
familial factors. We will assess interaction effects between H. pylori
infection, genetic susceptibility, environmental and familial factors on the
risk of chronic gastritis and stomach cancer. We only request funding for
H. pylori infection detection, DNA extraction, and GST M1 and T1 measurement
for these subjects. The results may be useful in the future planning and
designing an appropriate intervention study in this high risk area which can
reduce the incidence of gastric cancer in the high risk population.