Southern Arizona has among the highest skin cancer rates in the world
and the Arizona Cancer Center has an active and unique registry for
identification of all skin cancers diagnosed within three southeastern
counties of the state. Little is known, however, about the role genetic
risk factors have in the etiology of cutaneous melanoma within this
region and how genetics and environment, most particularly high
ultraviolet exposures, interact. The primary objective of this project is
to develop and evaluate a system to routinely identify the family history
of newly diagnosed melanoma patients and develop a repository of
genetic information for melanoma cases in a defined population. This
project proposed to develop the resources and experiences needed prior
to proposing a more complex genetic epidemiologic investigation in
Arizona of cutaneous malignant melanoma.
This two year project proposes to incorporate the collection of family
history data for all cutaneous malignant melanoma cases identified by
the Southeastern Arizona Skin Cancer Registry. This routine assessment
would allow identification from a defined geographic population of
potential melanoma families with more than one first-degree relative with
melanoma. These cases and families could then be available for
recruitment into subsequent, focused genetic studies. We propose to
also collect and analyze samples for mutational analyses of the
p16INK4/CDK2N gene in a series of select kindreds.
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- The DCCPS Team.