||5R01CA077014-02 Interpret this number
||Nicotine Withdrawal Syndrome in Adolescent Smokers
DESCRIPTION: (Applicant's Description)
The applicants propose a prospective study to characterize the nature and
severity of abstinence effects which occur during nicotine deprivation in a
sample of adolescent smokers (age range 13-17). The study will be conducted
in two stages. In Stage 1, the applicants will assess subjective (craving
DSM-IV nicotine withdrawal symptoms) and objective abstinence effects (heart
rate, blood pressure) in 200 adolescent smokers on three separate occasions
over the course of an 8 hr. Period. In Stage 1, participants will be
allowed to smoke cigarettes on an ad lib basis. In Stage 2, these same
adolescent smokers will be randomized to wear a 15 mg nicotine patch (n=100)
for 8 hrs and to refrain from smoking over this period. During this second
8 hr period, the applicants will again measure subjective and objective
abstinence effects on three separate occasions. The specific aims of Stage
2 are as follows: (1) to measure subjective and objective abstinence
effects during an 8 hour period of abstinence; (2) to study the effect of a
transdermal nicotine patch in alleviating the development of subjective
abstinence effects associated with an 8 hr period of abstinence. Three
primary hypotheses will be examined in Stage 2: Hypothesis #1: Subjective
abstinence effects that develop over an 8 hr period of nicotine deprivation
will be significantly higher than subjective abstinence effects measured
during 8 hrs of ad lib smoking. Hypothesis #2: Heart rate measured during
an 8 hr period of nicotine deprivation will be significantly lower than
heart rate measure during 8 hrs of ad lib smoking. Hypothesis #3:
Adolescent smokers who refrain from smoking over an 8 hr period while
wearing one placebo patch. If, through studies such as the one the
applicants propose, it can be demonstrated that adolescent smokers
experience significant abstinence effects associated with nicotine
deprivation, increased attention may then be refocused on (a) how
pharmacologic and biologic factors interact with social processes to
influence smoking among children and adolescents; (b) how these factors may
affect the transition from experimental to regular use, and (c) how to
account for nicotine dependence in cessation treatments for adolescent
Do adolescent smokers experience withdrawal effects when deprived of nicotine?
, Ammerman S.
, Rojas N.
, Varady J.
, Haydel F.
, Robinson T.N.
Experimental and clinical psychopharmacology, 2001 May; 9(2), p. 176-82.