||5R01DK051345-04 Interpret this number
||New England Research Institutes, Inc.
||Retrospective Cohort Study-Prostate Cancer Risk Factors
Despite the fact that one out of ten men in the U.S. has prostate cancer
(PCa) during their lifetime (there are approximately 165,000 incident
cases and 35,000 deaths from the disease annually) relatively little sound
knowledge is available on the basic epidemiology of the condition. Work
to date is beset by methodologic problems, for example: 1)
unrepresentative convenience samples (often of patients); 2) imprecise
definition and determination of prostate cancer; 3) variability in field
methods and laboratory techniques; 4) single discipline studies which
overlook multifactorial contributions to PCa; 5) failure to follow well
characterized subjects over time, starting at earlier ages (say, 40
years); and 6) small sample sizes which provide inadequate statistical
power to adequately control important covariates.
This proposed retrospective cohort study will utilize data from the
Massachusetts Male Aging Study (MMAS), the largest representative male
endocrine data base presently available, to identify predictors of PCa.
Men originally interviewed in 1987-89 (T/1) will be recontacted in 1996-97
(T/2). Two cohorts will be distinguished: (a) those with prostate cancer
(n equals 50); (b) those without prostate cancer (n equals 1650). Next-
of-kin of decreased subjects will be interviewed, death certificates
obtained, and the Massachusetts Cancer Registry checked. Already
diagnosed non-fatal cases will be interviewed and permission sought to
review medical records. A third group identified through interview and
PSA as at-risk to PCa will be invited to visit the MGH, where a standard
urologic workup will be conducted. These methods should approach 100
percent ascertainment of PCa cases. Statistical power calculations
indicate that sufficient numbers will be available to answer the major
questions of interest.
Using longitudinal data (8 years of follow-up) from a large representative
sample, covering a broad age span (40-70 years at T/1), this study will
provide basic epidemiologic information concerning PCa: the role of 17
different hormones, life styles (dietary intake, physical activity, sexual
activity, cigarette and alcohol usage), fat topology, medications,
demographics, occupation, medical history and surgeries, family history,
among other variables. Multivariate techniques and sufficient numbers
will permit control for collinearity and confounding. Apart from
significant epidemiologic contributions this work will produce the first
quantifiable risk assessment instrument for PCa based on sound
epidemiologic data. Such an instrument will permit earlier identification
of men likely to eventually develop PCa, which is a stated purpose of the
If you are accessing this page during weekend or evening hours, the database may currently be offline for maintenance and should operational within a few hours. Otherwise, we have been notified of this error and will be addressing it immediately.
Please contact us
if this error persists.
We apologize for the inconvenience.
- The DCCPS Team.