||5R03CA071408-02 Interpret this number
||New York University School Of Medicine
||Biological Effects of Joint Replacement
The purpose of the proposed project is to determine whether
individuals undergoing total hip or knee replacement procedures with
medical devices containing chromium experience an elevation in the
levels of DNA-protein crosslinks (DPC), a highly sensitive marker
of early biological damige from exposure to chromium. The specific
* To assess whether the levels of DPC in peripheral lymphocytes of
joint replacement patients increase after the surgical procedure.
* To assess whether changes in circulating chromium concentration
correlates with changes in levels of DPC.
* To study the time-lag between surgery and the increase in levels
Since hip replacement patients have already been observed to be at
increased risk for development of connective tissue tumors, as well
as cancers of the kidney and prostate, the DPC assay has the
potential to become a monitoring tool to detect any long-term health
consequences from metal prosthetic devices containing chromium.
Fifty study participants will be recruited among patients undergoing
hip or knee replacement procedures. Blood will he collected prior
to surgery to establish a baseline measurement. Each participant
will be followed up at four periodic intervals for 12 months. In
addition to the DPC assay, circulating chromium concentration will
Changes in self-reported family history of breast cancer with change in case-control status.
, Toniolo P.G.
, Taioli E.
European journal of epidemiology, 2001; 17(6), p. 517-20.