Grant Number:	5R01CA074302-02 Interpret this number
Primary Investigator:	Finkelstein, Dianne
Organization:	Massachusetts General Hospital
Project Title:	Statistical Methods for Research in Cancer and AIDS
Fiscal Year:	1998

DESCRIPTION: (Adapted from investigator's abstract) In studies of AIDS and cancer, analysis is based on survival as well as disease progression. Patients are monitored for clinical events and longitudinally collected laboratory and clinical information which indicate disease progression... The goal of this research is the development of a useful approach to analyzing multiple outcomes of progression from a study with missing and censored data. 1) PI will develop a global test based on survival and measures of progression including possibly censored clinical events and longitudinal outcomes, (which may be missing). The test will be sensitive to differences in survival and progression, and can be applied for interim monitoring of a study. 2.) Methodology will be developed for modeling the relationship between two clinical events indicating progression, when one of the events may be interval censored. For this, a method will be developed for applying the proportional hazards model for a time-varying interval- censored covariate. 3.) A method will be developed for modeling the relationship between (possibly missing) longitudinal measures of progression and a (possibly censored) clinical event of progression, by applying the methods of isotonic regression to the estimation of functions in a generalized additive model.




A Test For The Relationship Between A Time-varying Marker And Both Recovery And Progression With Missing Data
Authors: Schoenfeld,D.A. , Rajicic,N. , Ficociello,L.H. , Finkelstein,D.M. .
Source: Statistics In Medicine, 2011-03-30 00:00:00.0; 30(7), p. 718-24.
PMID: 21394748
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A Score Test For Association Of A Longitudinal Marker And An Event With Missing Data
Authors: Finkelstein,D.M. , Wang,R. , Ficociello,L.H. , Schoenfeld,D.A. .
Source: Biometrics, 2010 Sep; 66(3), p. 726-32.
PMID: 19754923
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Analysis Of The Relationship Between Longitudinal Gene Expressions And Ordered Categorical Event Data
Authors: Rajicic N. , Finkelstein D.M. , Schoenfeld D.A. , Inflammation and Host Response to Injury Research Program Investigators .
Source: Statistics In Medicine, 2009-09-30 00:00:00.0; 28(22), p. 2817-32.
PMID: 19618375
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Bayesian Design Using Adult Data To Augment Pediatric Trials
Authors: Schoenfeld D.A. , Hui Zheng null , Finkelstein D.M. .
Source: Clinical Trials (london, England), 2009 Aug; 6(4), p. 297-304.
PMID: 19667026
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Analysis Of Familial Aggregation Studies With Complex Ascertainment Schemes
Authors: Matthews A.G. , Finkelstein D.M. , Betensky R.A. .
Source: Statistics In Medicine, 2008-10-30 00:00:00.0; 27(24), p. 5076-92.
PMID: 18618413
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Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.
Authors: Kerber R.A. , Amos C.I. , Yeap B.Y. , Finkelstein D.M. , Thomas D.C. .
Source: Bmc Medical Genetics, 2008-07-10 00:00:00.0; 9, p. 64.
EPub date: 2008-07-10 00:00:00.0.
PMID: 18616822
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Multivariate Logistic Regression For Familial Aggregation In Age At Disease Onset
Authors: Matthews A.G. , Finkelstein D.M. , Betensky R.A. .
Source: Lifetime Data Analysis, 2007 Jun; 13(2), p. 191-209.
PMID: 17410428
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Regression Analysis Of Failure Time Data With Informative Interval Censoring
Authors: Zhang Z. , Sun L. , Sun J. , Finkelstein D.M. .
Source: Statistics In Medicine, 2007-05-30 00:00:00.0; 26(12), p. 2533-46.
PMID: 17072823
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Survival Methods
Authors: Rao,S.R. , Schoenfeld,D.A. .
Source: Circulation, 2007-01-02 00:00:00.0; 115(1), p. 109-13.
PMID: 17200454
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Analysis Of Co-aggregation Of Cancer Based On Registry Data
Authors: Matthews,A.G. , Betensky,R.A. , Anton-Culver,H. , Bowen,D. , Griffin,C. , Isaacs,C. , Kasten,C. , Mineau,G. , Nayfield,S. , Schildkraut,J. , et al. .
Source: Community Genetics, 2006; 9(2), p. 87-92.
PMID: 16612058
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An Estimator For Treatment Comparisons Among Survivors In Randomized Trials
Authors: Hayden,D. , Pauler,D.K. , Schoenfeld,D. .
Source: Biometrics, 2005 Mar; 61(1), p. 305-10.
PMID: 15737107
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Modelling The Relationship Between Continuous Covariates And Clinical Events Using Isotonic Regression
Authors: Ancukiewicz,M. , Finkelstein,D.M. , Schoenfeld,D.A. .
Source: Statistics In Medicine, 2003-10-30 00:00:00.0; 22(20), p. 3151-9.
PMID: 14518020
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Comparing Survival Of A Sample To That Of A Standard Population
Authors: Finkelstein D.M. , Muzikansky A. , Schoenfeld D.A. .
Source: Journal Of The National Cancer Institute, 2003-10-01 00:00:00.0; 95(19), p. 1434-9.
PMID: 14519749
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Predicting Time To Prostate Cancer Recurrence Based On Joint Models For Non-linear Longitudinal Biomarkers And Event Time Outcomes
Authors: Pauler D.K. , Finkelstein D.M. .
Source: Statistics In Medicine, 2002-12-30 00:00:00.0; 21(24), p. 3897-911.
PMID: 12483774
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Analysis Of Failure Time Data With Dependent Interval Censoring
Authors: Finkelstein D.M. , Goggins W.B. , Schoenfeld D.A. .
Source: Biometrics, 2002 Jun; 58(2), p. 298-304.
PMID: 12071402
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Testing For Dependence Between Failure Time And Visit Compliance With Interval-censored Data
Authors: Betensky R.A. , Finkelstein D.M. .
Source: Biometrics, 2002 Mar; 58(1), p. 58-63.
PMID: 11890327
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A Proportional Hazards Model For Multivariate Interval-censored Failure Time Data
Authors: Goggins W.B. , Finkelstein D.M. .
Source: Biometrics, 2000 Sep; 56(3), p. 940-3.
PMID: 10985240
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A non-parametric maximum likelihood estimator for bivariate interval censored data.
Authors: Betensky R.A. , Finkelstein D.M. .
Source: Statistics In Medicine, 1999-11-30 00:00:00.0; 18(22), p. 3089-100.
PMID: 10544308
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An extension of Kendall's coefficient of concordance to bivariate interval censored data.
Authors: Betensky R.A. , Finkelstein D.M. .
Source: Statistics In Medicine, 1999-11-30 00:00:00.0; 18(22), p. 3101-9.
PMID: 10544309
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Applying The Cox Proportional Hazards Model For Analysis Of Latency Data With Interval Censoring
Authors: Goggins W.B. , Finkelstein D.M. , Zaslavsky A.M. .
Source: Statistics In Medicine, 1999-10-30 00:00:00.0; 18(20), p. 2737-47.
PMID: 10521863
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Combining Mortality And Longitudinal Measures In Clinical Trials
Authors: Finkelstein D.M. , Schoenfeld D.A. .
Source: Statistics In Medicine, 1999-06-15 00:00:00.0; 18(11), p. 1341-54.
PMID: 10399200
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Applying The Cox Proportional Hazards Model When The Change Time Of A Binary Time-varying Covariate Is Interval Censored
Authors: Goggins W.B. , Finkelstein D.M. , Zaslavsky A.M. .
Source: Biometrics, 1999 Jun; 55(2), p. 445-51.
PMID: 11318198
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A Markov Chain Monte Carlo Em Algorithm For Analyzing Interval-censored Data Under The Cox Proportional Hazards Model
Authors: Goggins W.B. , Finkelstein D.M. , Schoenfeld D.A. , Zaslavsky A.M. .
Source: Biometrics, 1998 Dec; 54(4), p. 1498-507.
PMID: 9883548
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