Grant Details
Grant Number: |
5R01CA051923-08 Interpret this number |
Primary Investigator: |
Haile, Robert |
Organization: |
University Of Southern California |
Project Title: |
Sigmoidoscopy-Based Case Control Study of Polyps |
Fiscal Year: |
1998 |
Abstract
This is a revised renewal application for our ongoing case-control study
of nutritional and other risk factors for adenomatous polyps of the large
bowel. Subjects are asymptomatic persons who attended a sigmoidoscopy
screening clinic at one of two Kaiser Permanente-Southern California
clinical centers. Cases (n=530) are persons with a first-time diagnosis of
at least one adenomatous polyp confirmed by biopsy. Controls (n=530) are
subjects found to have no adenomatous polyp at sigmoidoscopy and with no
history of large bowel neoplasia. Data are obtained from a food frequency
questionnaire, in-person interview, fasting blood sample, and pathology
material (including the recent addition of tumor blocks). In the current
study, we have exceeded the sample size goal and achieved very high
response rates (84% for cases, 82% for controls) for a study of this
nature.
Our objective for this renewal is to investigate gene-environment
interactions, including both "inherited susceptibility genes" and
"metabolic genes". During the next grant period, we plan to focus on a set
of mutator genes (hMSH2, hMLH1, PMS1, PMS2), NAT1, NAT2, and GST. hMSH2 is
a relatively common gene believed to be a major cause of HNPCC and other
forms of colon cancer/polyps. Molecular analyses of these genes
(principally looking for microsatellite instability and sequencing) are
planned that would enable us to a) estimate the prevalence of
microsatellite instability in polyps b) the number and type of mutations
in hMSH2, hMLH1, and PMS, c) the prevalence of these mutations. d) the
penetrance/risk associated with mutations, and e) identify factors that
may affect penetrance of these genes (including other genes, such as k-
ras, and environmental exposures). NAT helps determine acetylator status.
We propose to determine genotypes of NAT1 and NAT2. We will also genotype
GST1. This will enable us to estimate main effects for NAT and GST, and
interactions with protein intake in general, red meat, and tobacco smoke.
In order to achieve adequate statistical power to detect interactions. we
propose to double our sample size to 1200 cases and 1200 controls, using
essentially the same staff and protocol as our ongoing study. Achieving
this sample size would also enable us to begin more informative
explorations of nutrient-nutrient and physical activity-nutrient
interactions.
Publications
Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry.
Authors: Levine A.J.
, Win A.K.
, Buchanan D.D.
, Jenkins M.A.
, Baron J.A.
, Young J.P.
, Long T.I.
, Weisenberger D.J.
, Laird P.W.
, McCall R.L.
, et al.
.
Source: Cancer prevention research (Philadelphia, Pa.), 2012 Feb; 5(2), p. 328-35.
EPub date: 2011-12-05.
PMID: 22144422
Related Citations
Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.
Authors: Tippin B.L.
, Levine A.J.
, Materi A.M.
, Song W.L.
, Keku T.O.
, Goodman J.E.
, Sansbury L.B.
, Das S.
, Dai A.
, Kwong A.M.
, et al.
.
Source: Prostaglandins & other lipid mediators, 2012 Jan; 97(1-2), p. 22-8.
EPub date: 2011-07-28.
PMID: 21821144
Related Citations
Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.
Authors: Lin H.J.
, Lakkides K.M.
, Keku T.O.
, Reddy S.T.
, Louie A.D.
, Kau I.H.
, Zhou H.
, Gim J.S.
, Ma H.L.
, Matthies C.F.
, et al.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002 Nov; 11(11), p. 1305-15.
PMID: 12433707
Related Citations
Glutathione transferase GSTT1, broccoli, and prevalence of colorectal adenomas.
Authors: Lin H.J.
, Zhou H.
, Dai A.
, Huang H.F.
, Lin J.H.
, Frankl H.D.
, Lee E.R.
, Haile R.W.
.
Source: Pharmacogenetics, 2002 Mar; 12(2), p. 175-9.
PMID: 11875371
Related Citations
An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomas.
Authors: Wang W.
, Xue S.
, Ingles S.A.
, Chen Q.
, Diep A.T.
, Frankl H.D.
, Stolz A.
, Haile R.W.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001 Sep; 10(9), p. 931-6.
PMID: 11535543
Related Citations
A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas.
Authors: Cortessis V.
, Siegmund K.
, Chen Q.
, Zhou N.
, Diep A.
, Frankl H.
, Lee E.
, Zhu Q.S.
, Haile R.
, Levy D.
.
Source: Cancer research, 2001-03-15; 61(6), p. 2381-5.
PMID: 11289100
Related Citations
The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk.
Authors: Levine A.J.
, Siegmund K.D.
, Ervin C.M.
, Diep A.
, Lee E.R.
, Frankl H.D.
, Haile R.W.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000 Jul; 9(7), p. 657-63.
PMID: 10919734
Related Citations
A case-control study of colorectal adenomatous polyps and consumption of foods containing partially hydrogenated oils.
Authors: McKelvey W.
, Greenland S.
, Chen M.J.
, Longnecker M.P.
, Frankl H.D.
, Lee E.R.
, Haile R.W.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999 Jun; 8(6), p. 519-24.
PMID: 10385142
Related Citations
Obesity, weight gain, large weight changes, and adenomatous polyps of the left colon and rectum.
Authors: Bird C.L.
, Frankl H.D.
, Lee E.R.
, Haile R.W.
.
Source: American journal of epidemiology, 1998-04-01; 147(7), p. 670-80.
PMID: 9554606
Related Citations
Plasma tocopherol and prevalence of colorectal adenomas in a multiethnic population.
Authors: Ingles S.A.
, Bird C.L.
, Shikany J.M.
, Frankl H.D.
, Lee E.R.
, Haile R.W.
.
Source: Cancer research, 1998-02-15; 58(4), p. 661-6.
PMID: 9485018
Related Citations
A sigmoidoscopy-based case-control study of polyps: macronutrients, fiber and meat consumption.
Authors: Haile R.W.
, Witte J.S.
, Longnecker M.P.
, Probst-Hensch N.
, Chen M.J.
, Harper J.
, Frankl H.D.
, Lee E.R.
.
Source: International journal of cancer, 1997-11-14; 73(4), p. 497-502.
PMID: 9389562
Related Citations
A nested approach to evaluating dose-response and trend.
Authors: Witte J.S.
, Greenland S.
.
Source: Annals of epidemiology, 1997 Apr; 7(3), p. 188-93.
PMID: 9141641
Related Citations
Plasma carotenoids and the prevalence of adenomatous polyps of the distal colon and rectum.
Authors: Shikany J.M.
, Witte J.S.
, Henning S.M.
, Swendseid M.E.
, Bird C.L.
, Frankl H.D.
, Lee E.R.
, Haile R.W.
.
Source: American journal of epidemiology, 1997-03-15; 145(6), p. 552-7.
PMID: 9063346
Related Citations
Meat preparation and colorectal adenomas in a large sigmoidoscopy-based case-control study in California (United States).
Authors: Probst-Hensch N.M.
, Sinha R.
, Longnecker M.P.
, Witte J.S.
, Ingles S.A.
, Frankl H.D.
, Lee E.R.
, Haile R.W.
.
Source: Cancer causes & control : CCC, 1997 Mar; 8(2), p. 175-83.
PMID: 9134241
Related Citations
Recent and past physical activity and prevalence of colorectal adenomas.
Authors: Enger S.M.
, Longnecker M.P.
, Lee E.R.
, Frankl H.D.
, Haile R.W.
.
Source: British journal of cancer, 1997; 75(5), p. 740-5.
PMID: 9043034
Related Citations
Relation of vegetable, fruit, and grain consumption to colorectal adenomatous polyps.
Authors: Witte J.S.
, Longnecker M.P.
, Bird C.L.
, Lee E.R.
, Frankl H.D.
, Haile R.W.
.
Source: American journal of epidemiology, 1996-12-01; 144(11), p. 1015-25.
PMID: 8942431
Related Citations
Lack of association between the polyadenylation polymorphism in the NAT1 (acetyltransferase 1) gene and colorectal adenomas.
Authors: Probst-Hensch N.M.
, Haile R.W.
, Li D.S.
, Sakamoto G.T.
, Louie A.D.
, Lin B.K.
, Frankl H.D.
, Lee E.R.
, Lin H.J.
.
Source: Carcinogenesis, 1996 Oct; 17(10), p. 2125-9.
PMID: 8895478
Related Citations
Serum lipids and adenomas of the left colon and rectum.
Authors: Bird C.L.
, Ingles S.A.
, Frankl H.D.
, Lee E.R.
, Longnecker M.P.
, Haile R.W.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996 Aug; 5(8), p. 607-12.
PMID: 8824362
Related Citations
Plasma ferritin, iron intake, and the risk of colorectal polyps.
Authors: Bird C.L.
, Witte J.S.
, Swendseid M.E.
, Shikany J.M.
, Hunt I.F.
, Frankl H.D.
, Lee E.R.
, Longnecker M.P.
, Haile R.W.
.
Source: American journal of epidemiology, 1996-07-01; 144(1), p. 34-41.
PMID: 8659483
Related Citations
Alcohol and smoking in relation to the prevalence of adenomatous colorectal polyps detected at sigmoidoscopy.
Authors: Longnecker M.P.
, Chen M.J.
, Probst-Hensch N.M.
, Harper J.M.
, Lee E.R.
, Frankl H.D.
, Haile R.W.
.
Source: Epidemiology (Cambridge, Mass.), 1996 May; 7(3), p. 275-80.
PMID: 8728441
Related Citations
Dietary intake of specific carotenoids and vitamins A, C, and E, and prevalence of colorectal adenomas.
Authors: Enger S.M.
, Longnecker M.P.
, Chen M.J.
, Harper J.M.
, Lee E.R.
, Frankl H.D.
, Haile R.W.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996 Mar; 5(3), p. 147-53.
PMID: 8833613
Related Citations
Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps.
Authors: Bird C.L.
, Swendseid M.E.
, Witte J.S.
, Shikany J.M.
, Hunt I.F.
, Frankl H.D.
, Lee E.R.
, Longnecker M.P.
, Haile R.W.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1995 Oct-Nov; 4(7), p. 709-14.
PMID: 8672986
Related Citations
Acetylation polymorphism and prevalence of colorectal adenomas.
Authors: Probst-Hensch N.M.
, Haile R.W.
, Ingles S.A.
, Longnecker M.P.
, Han C.Y.
, Lin B.K.
, Lee D.B.
, Sakamoto G.T.
, Frankl H.D.
, Lee E.R.
.
Source: Cancer research, 1995-05-15; 55(10), p. 2017-20.
PMID: 7743494
Related Citations
Questionnaire assessment of intake of specific carotenoids.
Authors: Enger S.M.
, Longnecker M.P.
, Shikany J.M.
, Swenseid M.E.
, Chen M.J.
, Harper J.M.
, Haile R.W.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1995 Apr-May; 4(3), p. 201-5.
PMID: 7606194
Related Citations
Glutathione transferase (GSTM1) null genotype, smoking, and prevalence of colorectal adenomas.
Authors: Lin H.J.
, Probst-Hensch N.M.
, Ingles S.A.
, Han C.Y.
, Lin B.K.
, Lee D.B.
, Frankl H.D.
, Lee E.R.
, Longnecker M.P.
, Haile R.W.
.
Source: Cancer research, 1995-03-15; 55(6), p. 1224-6.
PMID: 7882312
Related Citations