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Grant Details

Grant Number: 5R01CA051923-08 Interpret this number
Primary Investigator: Haile, Robert
Organization: University Of Southern California
Project Title: Sigmoidoscopy-Based Case Control Study of Polyps
Fiscal Year: 1998
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Abstract

This is a revised renewal application for our ongoing case-control study of nutritional and other risk factors for adenomatous polyps of the large bowel. Subjects are asymptomatic persons who attended a sigmoidoscopy screening clinic at one of two Kaiser Permanente-Southern California clinical centers. Cases (n=530) are persons with a first-time diagnosis of at least one adenomatous polyp confirmed by biopsy. Controls (n=530) are subjects found to have no adenomatous polyp at sigmoidoscopy and with no history of large bowel neoplasia. Data are obtained from a food frequency questionnaire, in-person interview, fasting blood sample, and pathology material (including the recent addition of tumor blocks). In the current study, we have exceeded the sample size goal and achieved very high response rates (84% for cases, 82% for controls) for a study of this nature. Our objective for this renewal is to investigate gene-environment interactions, including both "inherited susceptibility genes" and "metabolic genes". During the next grant period, we plan to focus on a set of mutator genes (hMSH2, hMLH1, PMS1, PMS2), NAT1, NAT2, and GST. hMSH2 is a relatively common gene believed to be a major cause of HNPCC and other forms of colon cancer/polyps. Molecular analyses of these genes (principally looking for microsatellite instability and sequencing) are planned that would enable us to a) estimate the prevalence of microsatellite instability in polyps b) the number and type of mutations in hMSH2, hMLH1, and PMS, c) the prevalence of these mutations. d) the penetrance/risk associated with mutations, and e) identify factors that may affect penetrance of these genes (including other genes, such as k- ras, and environmental exposures). NAT helps determine acetylator status. We propose to determine genotypes of NAT1 and NAT2. We will also genotype GST1. This will enable us to estimate main effects for NAT and GST, and interactions with protein intake in general, red meat, and tobacco smoke. In order to achieve adequate statistical power to detect interactions. we propose to double our sample size to 1200 cases and 1200 controls, using essentially the same staff and protocol as our ongoing study. Achieving this sample size would also enable us to begin more informative explorations of nutrient-nutrient and physical activity-nutrient interactions.

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Publications

Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry.
Authors: Levine A.J. , Win A.K. , Buchanan D.D. , Jenkins M.A. , Baron J.A. , Young J.P. , Long T.I. , Weisenberger D.J. , Laird P.W. , McCall R.L. , et al. .
Source: Cancer prevention research (Philadelphia, Pa.), 2012 Feb; 5(2), p. 328-35.
EPub date: 2011-12-05.
PMID: 22144422
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Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.
Authors: Tippin B.L. , Levine A.J. , Materi A.M. , Song W.L. , Keku T.O. , Goodman J.E. , Sansbury L.B. , Das S. , Dai A. , Kwong A.M. , et al. .
Source: Prostaglandins & other lipid mediators, 2012 Jan; 97(1-2), p. 22-8.
EPub date: 2011-07-28.
PMID: 21821144
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Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.
Authors: Lin H.J. , Lakkides K.M. , Keku T.O. , Reddy S.T. , Louie A.D. , Kau I.H. , Zhou H. , Gim J.S. , Ma H.L. , Matthies C.F. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002 Nov; 11(11), p. 1305-15.
PMID: 12433707
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Glutathione transferase GSTT1, broccoli, and prevalence of colorectal adenomas.
Authors: Lin H.J. , Zhou H. , Dai A. , Huang H.F. , Lin J.H. , Frankl H.D. , Lee E.R. , Haile R.W. .
Source: Pharmacogenetics, 2002 Mar; 12(2), p. 175-9.
PMID: 11875371
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An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomas.
Authors: Wang W. , Xue S. , Ingles S.A. , Chen Q. , Diep A.T. , Frankl H.D. , Stolz A. , Haile R.W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001 Sep; 10(9), p. 931-6.
PMID: 11535543
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A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas.
Authors: Cortessis V. , Siegmund K. , Chen Q. , Zhou N. , Diep A. , Frankl H. , Lee E. , Zhu Q.S. , Haile R. , Levy D. .
Source: Cancer research, 2001-03-15; 61(6), p. 2381-5.
PMID: 11289100
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The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk.
Authors: Levine A.J. , Siegmund K.D. , Ervin C.M. , Diep A. , Lee E.R. , Frankl H.D. , Haile R.W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000 Jul; 9(7), p. 657-63.
PMID: 10919734
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A case-control study of colorectal adenomatous polyps and consumption of foods containing partially hydrogenated oils.
Authors: McKelvey W. , Greenland S. , Chen M.J. , Longnecker M.P. , Frankl H.D. , Lee E.R. , Haile R.W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999 Jun; 8(6), p. 519-24.
PMID: 10385142
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Obesity, weight gain, large weight changes, and adenomatous polyps of the left colon and rectum.
Authors: Bird C.L. , Frankl H.D. , Lee E.R. , Haile R.W. .
Source: American journal of epidemiology, 1998-04-01; 147(7), p. 670-80.
PMID: 9554606
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Plasma tocopherol and prevalence of colorectal adenomas in a multiethnic population.
Authors: Ingles S.A. , Bird C.L. , Shikany J.M. , Frankl H.D. , Lee E.R. , Haile R.W. .
Source: Cancer research, 1998-02-15; 58(4), p. 661-6.
PMID: 9485018
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A sigmoidoscopy-based case-control study of polyps: macronutrients, fiber and meat consumption.
Authors: Haile R.W. , Witte J.S. , Longnecker M.P. , Probst-Hensch N. , Chen M.J. , Harper J. , Frankl H.D. , Lee E.R. .
Source: International journal of cancer, 1997-11-14; 73(4), p. 497-502.
PMID: 9389562
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A nested approach to evaluating dose-response and trend.
Authors: Witte J.S. , Greenland S. .
Source: Annals of epidemiology, 1997 Apr; 7(3), p. 188-93.
PMID: 9141641
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Plasma carotenoids and the prevalence of adenomatous polyps of the distal colon and rectum.
Authors: Shikany J.M. , Witte J.S. , Henning S.M. , Swendseid M.E. , Bird C.L. , Frankl H.D. , Lee E.R. , Haile R.W. .
Source: American journal of epidemiology, 1997-03-15; 145(6), p. 552-7.
PMID: 9063346
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Meat preparation and colorectal adenomas in a large sigmoidoscopy-based case-control study in California (United States).
Authors: Probst-Hensch N.M. , Sinha R. , Longnecker M.P. , Witte J.S. , Ingles S.A. , Frankl H.D. , Lee E.R. , Haile R.W. .
Source: Cancer causes & control : CCC, 1997 Mar; 8(2), p. 175-83.
PMID: 9134241
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Recent and past physical activity and prevalence of colorectal adenomas.
Authors: Enger S.M. , Longnecker M.P. , Lee E.R. , Frankl H.D. , Haile R.W. .
Source: British journal of cancer, 1997; 75(5), p. 740-5.
PMID: 9043034
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Relation of vegetable, fruit, and grain consumption to colorectal adenomatous polyps.
Authors: Witte J.S. , Longnecker M.P. , Bird C.L. , Lee E.R. , Frankl H.D. , Haile R.W. .
Source: American journal of epidemiology, 1996-12-01; 144(11), p. 1015-25.
PMID: 8942431
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Lack of association between the polyadenylation polymorphism in the NAT1 (acetyltransferase 1) gene and colorectal adenomas.
Authors: Probst-Hensch N.M. , Haile R.W. , Li D.S. , Sakamoto G.T. , Louie A.D. , Lin B.K. , Frankl H.D. , Lee E.R. , Lin H.J. .
Source: Carcinogenesis, 1996 Oct; 17(10), p. 2125-9.
PMID: 8895478
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Serum lipids and adenomas of the left colon and rectum.
Authors: Bird C.L. , Ingles S.A. , Frankl H.D. , Lee E.R. , Longnecker M.P. , Haile R.W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996 Aug; 5(8), p. 607-12.
PMID: 8824362
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Plasma ferritin, iron intake, and the risk of colorectal polyps.
Authors: Bird C.L. , Witte J.S. , Swendseid M.E. , Shikany J.M. , Hunt I.F. , Frankl H.D. , Lee E.R. , Longnecker M.P. , Haile R.W. .
Source: American journal of epidemiology, 1996-07-01; 144(1), p. 34-41.
PMID: 8659483
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Alcohol and smoking in relation to the prevalence of adenomatous colorectal polyps detected at sigmoidoscopy.
Authors: Longnecker M.P. , Chen M.J. , Probst-Hensch N.M. , Harper J.M. , Lee E.R. , Frankl H.D. , Haile R.W. .
Source: Epidemiology (Cambridge, Mass.), 1996 May; 7(3), p. 275-80.
PMID: 8728441
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Dietary intake of specific carotenoids and vitamins A, C, and E, and prevalence of colorectal adenomas.
Authors: Enger S.M. , Longnecker M.P. , Chen M.J. , Harper J.M. , Lee E.R. , Frankl H.D. , Haile R.W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996 Mar; 5(3), p. 147-53.
PMID: 8833613
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Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps.
Authors: Bird C.L. , Swendseid M.E. , Witte J.S. , Shikany J.M. , Hunt I.F. , Frankl H.D. , Lee E.R. , Longnecker M.P. , Haile R.W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1995 Oct-Nov; 4(7), p. 709-14.
PMID: 8672986
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Acetylation polymorphism and prevalence of colorectal adenomas.
Authors: Probst-Hensch N.M. , Haile R.W. , Ingles S.A. , Longnecker M.P. , Han C.Y. , Lin B.K. , Lee D.B. , Sakamoto G.T. , Frankl H.D. , Lee E.R. .
Source: Cancer research, 1995-05-15; 55(10), p. 2017-20.
PMID: 7743494
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Questionnaire assessment of intake of specific carotenoids.
Authors: Enger S.M. , Longnecker M.P. , Shikany J.M. , Swenseid M.E. , Chen M.J. , Harper J.M. , Haile R.W. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1995 Apr-May; 4(3), p. 201-5.
PMID: 7606194
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Glutathione transferase (GSTM1) null genotype, smoking, and prevalence of colorectal adenomas.
Authors: Lin H.J. , Probst-Hensch N.M. , Ingles S.A. , Han C.Y. , Lin B.K. , Lee D.B. , Frankl H.D. , Lee E.R. , Longnecker M.P. , Haile R.W. .
Source: Cancer research, 1995-03-15; 55(6), p. 1224-6.
PMID: 7882312
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