Grant Details
Grant Number: |
5R29CA057466-05 Interpret this number |
Primary Investigator: |
Coker, Ann |
Organization: |
University Of South Carolina At Columbia |
Project Title: |
Cin Risk-Interactions of HPV, Diet, Smoking, and Race |
Fiscal Year: |
1998 |
Abstract
The purpose of this nested case-control study is to investigate the
synergistic relationship between human papillomaviruses (HPV) and diet,
cigarette smoking and race, in the development of cervical intraepithelial
neoplasia (CIN) among low-income and rural South Carolinians. South
Carolina health department family planning clinic clients will be the
cohort within which this study is nested. From March 1991 to March 1992
cervical samples were collected from each woman receiving a Pap smear at
one of eleven clinics in the Charleston area (N = 8,000). Incident cases
will be women developing CIN (either CIN I, II, or III) over this FIRST
Award time period who also had a normal Pap smear between March 1991-1992
(and had a cervical sample collected for HPV typing). Controls will be
women with normal cervical cytology in 1991-1992 who did not develop CIN
in the subsequent follow-up years. The HPV DNA type of these cases and
controls will be determined in the stored sample using polymerase chain
reaction techniques.
Cases and controls will be interviewed over the telephone to determine
their active and passive cigarette smoke exposure, age, education, parity,
contraceptive use, sexual and reproductive history, and history of
sexually transmitted diseases. Dietary intake will be determined using a
self-administered short version of the NCI Health Habits and Diet History
questionnaire. The analysis will compare cases with controls regarding (a)
HPV infection status, (b) cigarette smoke exposure (active and passive),
and (c) dietary nutrient levels. We will investigate the consistency of
findings across racial groups (blacks and whites) by CIN level.
Interaction between HPV 16/18/33 and dietary nutrient levels, smoking
exposures, race and contraceptive use, on CIN risk will also be evaluated.
Publications
Life Stressors Are An Important Reason For Women Discontinuing Follow-up Care For Cervical Neoplasia
Authors: Coker,A.L.
, Bond,S.M.
, Pirisi,L.A.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2006 Feb; 15(2), p. 321-5.
PMID: 16492923
Related Citations
Psychosocial Stress And Cervical Neoplasia Risk
Authors: Coker,A.L.
, Bond,S.
, Madeleine,M.M.
, Luchok,K.
, Pirisi,L.
.
Source: Psychosomatic Medicine, 2003 Jul-Aug; 65(4), p. 644-51.
PMID: 12883116
Related Citations
Active and passive smoking, high-risk human papillomaviruses and cervical neoplasia.
Authors: Coker A.L.
, Bond S.M.
, Williams A.
, Gerasimova T.
, Pirisi L.
.
Source: Cancer Detection And Prevention, 2002; 26(2), p. 121-8.
PMID: 12102146
Related Citations
Hormonal and barrier methods of contraception, oncogenic human papillomaviruses, and cervical squamous intraepithelial lesion development.
Authors: Coker A.L.
, Sanders L.C.
, Bond S.M.
, Gerasimova T.
, Pirisi L.
.
Source: Journal Of Women's Health & Gender-based Medicine, 2001 Jun; 10(5), p. 441-9.
PMID: 11445043
Related Citations
Adeno-associated virus is associated with a lower risk of high-grade cervical neoplasia.
Authors: Coker A.L.
, Russell R.B.
, Bond S.M.
, Pirisi L.
, Liu Y.
, Mane M.
, Kokorina N.
, Gerasimova T.
, Hermonat P.L.
.
Source: Experimental And Molecular Pathology, 2001 Apr; 70(2), p. 83-9.
PMID: 11263951
Related Citations
High-risk HPVs and risk of cervical neoplasia: a nested case-control study.
Authors: Coker A.L.
, Gerasimova T.
, King M.R.
, Jackson K.L.
, Pirisi L.
.
Source: Experimental And Molecular Pathology, 2001 Apr; 70(2), p. 90-5.
PMID: 11263952
Related Citations
Intimate partner violence and cervical neoplasia.
Authors: Coker A.L.
, Sanderson M.
, Fadden M.K.
, Pirisi L.
.
Source: Journal Of Women's Health & Gender-based Medicine, 2000 Nov; 9(9), p. 1015-23.
PMID: 11103102
Related Citations