Grant Details
Grant Number: |
5R01CA055348-05 Interpret this number |
Primary Investigator: |
Schiff, Melissa |
Organization: |
University Of New Mexico |
Project Title: |
Epidemiology of Cervical Dysplasia in Am Indian Women |
Fiscal Year: |
1998 |
Abstract
Although cervical dysplasia is a major cause of morbidity in women
worldwide, few published studies have assessed the risk factors for its
development. American Indian women are at high risk for development of
both cervical dysplasia and cervical cancer, yet published data are scant
that identify the risk factors for the development of cervical lesions in
this minority group.
To assess the risk factors for the development of moderate dysplasia,
severe dysplasia, and carcinoma in situ in New Mexico's American Indian
women, we propose to conduct a case-control study at several Indian Health
Service-affiliated outpatient clinics. The study design incorporates an
integrated approach to investigate the relationship of numerous exposures
in the development of high-grade dysplastic cervical lesions. Data will
be obtained from study participants through extensive interviews, physical
and colposcopic examinations, microbiologic studies, serologic studies of
antibodies to sexually transmitted disease agents, and laboratory studies
of cervical cytologic and histologic specimens. Interviews will be
specifically directed to assess the associations of sexual behavior, past
sexually transmitted diseases, contraceptive techniques, hygienic
practices, cigarette smoking, and micronutrient consumption in the
development of cervical dysplasia. Laboratory studies will be primarily
directed to assessment of effects of current and past sexually transmitted
infections, plasma micronutrients, and presence of specific HLA alleles in
the development of cervical dysplasia.
This research will identify risk factors for development of high-grade
cervical dysplasia among American Indian women in New Mexico. This
research will also allow comparison of prevalence and patterns of risk
factors for cervical dysplasia in American Indian women with data obtained
from a similar, recently completed study in New Mexico Hispanic and non-
Hispanic white women. Thus, from an etiologic perspective, the
investigation will allow evaluation of heterogeneity of risk factors for
cervical dysplasia among culturally-diverse populations in the same
geographic region. From a public health perspective, this research should
lead to prevention strategies that will ultimately decrease the rates of
cervical dysplasia and cervical cancer, particularly among the high-risk
American Indian women of the Southwest.
Publications
HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women.
Authors: Schiff M.A.
, Apple R.J.
, Lin P.
, Nelson J.L.
, Wheeler C.M.
, Becker T.M.
.
Source: Human immunology, 2005 Oct; 66(10), p. 1050-6.
EPub date: 2005-10-25.
PMID: 16386646
Related Citations
The injury severity score in pregnant trauma patients: predicting placental abruption and fetal death.
Authors: Schiff M.A.
, Holt V.L.
.
Source: The Journal of trauma, 2002 Nov; 53(5), p. 946-9.
PMID: 12435948
Related Citations
Maternal and infant outcomes after injury during pregnancy in Washington State from 1989 to 1997.
Authors: Schiff M.A.
, Holt V.L.
, Daling J.R.
.
Source: The Journal of trauma, 2002 Nov; 53(5), p. 939-45.
PMID: 12435947
Related Citations
Serum carotenoids and risk of cervical intraepithelial neoplasia in Southwestern American Indian women.
Authors: Schiff M.A.
, Patterson R.E.
, Baumgartner R.N.
, Masuk M.
, van Asselt-King L.
, Wheeler C.M.
, Becker T.M.
.
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001 Nov; 10(11), p. 1219-22.
PMID: 11700272
Related Citations
Contraceptive and reproductive risk factors for cervical intraepithelial neoplasia in American Indian women.
Authors: Schiff M.
, Miller J.
, Masuk M.
, van Asselt King L.
, Altobelli K.K.
, Wheeler C.M.
, Becker T.M.
.
Source: International journal of epidemiology, 2000 Dec; 29(6), p. 983-90.
PMID: 11101538
Related Citations
Risk factors for cervical intraepithelial neoplasia in southwestern American Indian women.
Authors: Schiff M.
, Becker T.M.
, Masuk M.
, van Asselt-King L.
, Wheeler C.M.
, Altobelli K.K.
, North C.Q.
, Nahmias A.J.
.
Source: American journal of epidemiology, 2000-10-15; 152(8), p. 716-26.
PMID: 11052549
Related Citations
Serum micronutrients and cervical dysplasia in Southwestern American Indian women.
Authors: Yeo A.S.
, Schiff M.A.
, Montoya G.
, Masuk M.
, van Asselt-King L.
, Becker T.M.
.
Source: Nutrition and cancer, 2000; 38(2), p. 141-50.
PMID: 11525590
Related Citations
Risk factors for cervical intraepithelial neoplasm in Alaska Native women: a pilot study.
Authors: MacLehose R.F.
, Harpster A.
, Lanier A.P.
, Schiff M.A.
, Koehler K.
, Murphy N.
, Becker T.M.
.
Source: Alaska medicine, 1999 Oct-Dec; 41(4), p. 76-85.
PMID: 10710795
Related Citations