||1R03CA078203-01 Interpret this number
||University Of Colorado Denver
||Preexclampsia and Risk of Breast and Endometrial Cancer
DESCRIPTION (Applicant's Description) Breast cancer is associated with
endogenous hormone levels but the exact relationships - and underlaying
mechanisms remain unclear. Recent studies have suggested that women who
have experienced preeclampsia during pregnancy, and women who were exposed
to preeclampsia when they were themselves developing fetuses in utero might
be at reduced risk for breast cancer. Because preeclampsia is characterized
by abnormal levels of circulating hormones, these relationships may be due
to hormonal effects on the developing fetus or to hormonal profiles that
predispose women both to preeclampsia during pregnancy and to a reduced risk
of breast cancer later in life. We propose to investigate the relationship
between breast cancer and both personal history of preeclampsia during a
prior pregnancy and exposure to preeclampsia in utero by conducting a large
study using linked birth and cancer registry data from New York State.
Because endometrial cancer is even more clearly linked to estrogens than is
breast cancer, we will also examine the association between preeclampsia and
risk for endometrial cancer using this same study design. Using a
case-control design, we will analyze anonymous, linked birth record and
tumor registry data from the New York State and New York City Health
Departments as our primary information source. Cases will be identified
through the New York State Cancer Registry, defined as women who were
diagnosed with breast or endometrial cancer between 1978 and 1996. Each
woman's cancer registry record will then be matched with those pertaining to
all of her pregnancies in New York subsequent to 1961 (the earliest year of
computerized birth records). Controls will be frequency matched to cases by
year and hospital of their first pregnancy, or of their own birth.
Preeclampsia during the first pregnancy will be the primary exposure of
interest for subjects having a first pregnancy in New York after 1961. For
subjects born in New York after 1961, maternal preeclampsia during that
gestation (i.e., in utero exposure) will be the primary exposure of
interest. Logistic regression analyses will be used to determine the
independent effects of personal history of preeclampsia and in utero
exposure to preeclampsia on cancer risk, and to assess the influence of
potential confounding factors. This study is large enough to provide power
to explore effect modification of the cancer-preeclampsia association by
selected factors, including age at cancer diagnosis, age at first pregnancy,
and race/ethnicity. Findings from this study can suggest specific avenues
for future research among women who have been affected by preeclampsia to
better understand the relationships between hormonal profiles in life and
the etiology of breast and endometrial cancer.
First pregnancy characteristics and subsequent breast cancer risk among young women.
, Byers T.E.
International journal of cancer, 2004-11-01; 112(2), p. 306-11.
Smoking during pregnancy and breast cancer risk in very young women (United States).
, Byers T.E.
Cancer causes & control : CCC, 2001 Feb; 12(2), p. 179-85.
Birth characteristics and subsequent risk for breast cancer in very young women.
, Byers T.
, Schymura M.
American journal of epidemiology, 2000-12-15; 152(12), p. 1121-8.