The goal of this proposal is to reactivate intensive analysis of the Utah
Population Database. This database allows a large scale investigation of
the familial component of cancer of all sites in a reference population
with almost complete ascertainment of all cancer cases from 1966 to
present. A genealogy of approximately l million Utah descendants of the
Mormon pioneers originating with their common ancestors has been
previously constructed (Skolnick, 1977a; 1980). This collection of Utah
families has been computerized and linked into a genealogical database.
The genealogy has been linked to a registry of approximately 125,000 Utah
Cancer Registry records. We have demonstrated that the Mormons have a
typical Northern European gene frequency (McLellan et al., 1984) and
normal levels of inbreeding (Jorde and Skolnick, 1981). This population is
appropriate for inferences about cancer in populations of Northern
European descent. Cancer has been widely studied in this population
because of its unique lifestyle characteristics (Lyon et al., 1980a,b;
Gardner and Lyon, 1982a,b). Cancer rates in Utah for the years 1966 -1985
are low when compared to the U.S. Third National Cancer Survey (Cancer in
Utah 1988). This is largely due to the much lower Utah rates for smoking-
associated cancers. Conclusions based upon the study of this population
should be applicable to similar populations elsewhere. This project will
allow an exhaustive analysis of the familiality of cancer and will benefit
from collaborative development of methodology. The database will allow
hypotheses to be tested in an unbiased fashion, using population-based
samples. This database is unique in its ability to allow testing of such
hypotheses. The detailed description of the familial nature of cancer must
continue, as it is of fundamental significance for the studies of high
incidence families which have become so important in determining a genetic
component for many common cancers (Burt et al., 1985, Cannon-Albright et
al., 1988; Cannon-Albright et al., 1992; Goldgar et al., 1993). These
descriptive studies are a prelude to the detailed genetic and molecular
studies which are leading to the isolation and analysis of the genes which
predispose to familial cancer.
If you are accessing this page during weekend or evening hours, the database may currently be offline for maintenance and should operational within a few hours. Otherwise, we have been notified of this error and will be addressing it immediately.
Please contact us
if this error persists.
We apologize for the inconvenience.
- The DCCPS Team.