Grant Number:	5R01CA058684-05 Interpret this number
Primary Investigator:	Stampfer, Meir
Organization:	Brigham And Women'S Hospital
Project Title:	Dietary and Biochemical Markers of Prostate Cancer Risk
Fiscal Year:	1998

DESCRIPTION: (Adapted from Applicant's Abstract). The application proposes to continue to explore, using a prospective study design, the associations of specific biochemical factors with subsequent development and diagnosis of prostate cancer. Blood samples to be used in this study were collected at baseline in 1982 from 14,916 men in the ongoing Physicians Health Study. The blood will be analyzed, using a matched, nested, case-control design to evaluate hypotheses in three main areas: markers for early detection, hormonal factors, and nutritional biochemical factors. For early detection, the application posits that determination of plasma percent free PSA will markedly improve the sensitivity and specificity of PSA, especially for those with PSA values near the conventional level of "positive" (4.0 ng/ml). The plan is to assess the value of prostate-specific membrane antigen (PSMA) for early detection of metastatic disease. There are also plans to assay hormone levels (testosterone, dihydrotestosterone, 3a-androstanediol glucuronide, SHBG, estradiol) in plasma to relate these to prostate cancer risk. Analysis of the impact of genetic variations in the genes coding for the androgen receptor and 5-alpha-reductase (an important enzyme in androgen metabolism) will add further knowledge about prostate cancer aetiology, and will permit assessment of interactions with hormone levels. The major nutritional hypotheses relate to possible protective effects of lycopene and vitamin E, and possible adverse effects of specific fatty acids (especially alpha-linolenic acid and trans-fatty acids). In addition, studies are planned to explore interactions between the baseline carotenoid levels and the beta-carotene intervention. Prostate cancer endpoints are routinely documented as part of the trial follow-up, which is funded from other sources. The blood samples are already available for analysis. Hence, the proposed analysis will make efficient use of existing resources which provide the basis for a prospective study of prostate cancer. About 1,234 cases are projected by the end of the grant period, yielding sufficient statistical power for informative results.




Associations of Vitamin D-Related Biomarkers With Hypertension and the Renin-Angiotensin System in Men and Women.
Authors: Wang L. , Cook N.R. , Manson J.E. , Gaziano J.M. , Buring J.E. , Sesso H.D. .
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Source: Journal Of The National Cancer Institute, 2016 Nov; 108(11), .
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Delineation of body mass index trajectory predicting lowest risk of mortality in U.S. men using generalized additive mixed model.
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Source: Annals Of Epidemiology, 2016 10; 26(10), p. 698-703.e2.
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Dietary patterns after prostate cancer diagnosis in relation to disease-specific and total mortality.
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Blood levels of saturated and monounsaturated fatty acids as markers of de novo lipogenesis and risk of prostate cancer.
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Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies.
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Source: Cancer Prevention Research (philadelphia, Pa.), 2011 May; 4(5), p. 735-43.
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Genetic variation in RNASEL associated with prostate cancer risk and progression.
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Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival.
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A 25-year prospective study of plasma adiponectin and leptin concentrations and prostate cancer risk and survival.
Authors: Li H. , Stampfer M.J. , Mucci L. , Rifai N. , Qiu W. , Kurth T. , Ma J. .
Source: Clinical Chemistry, 2010 Jan; 56(1), p. 34-43.
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Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality: Physicians' Health Study.
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Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts.
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Authors: Rifai N. , Ma J. , Sacks F.M. , Ridker P.M. , Hernandez W.J. , Stampfer M.J. , Marcovina S.M. .
Source: Clinical Chemistry, 2004 Aug; 50(8), p. 1364-71.
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Source: Journal Of The National Cancer Institute, 2004-04-07 00:00:00.0; 96(7), p. 546-53.
PMID: 15069117
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Body iron stores and their determinants in healthy postmenopausal US women.
Authors: Liu J.M. , Hankinson S.E. , Stampfer M.J. , Rifai N. , Willett W.C. , Ma J. .
Source: The American Journal Of Clinical Nutrition, 2003 Dec; 78(6), p. 1160-7.
PMID: 14668279
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Geographical, seasonal and gender differences in folate status among Chinese adults.
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Source: The Journal Of Nutrition, 2003 Nov; 133(11), p. 3630-5.
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PMID: 14557109
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Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians.
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Source: Circulation, 2003-08-19 00:00:00.0; 108(7), p. 802-7.
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Association between the Met326Ile polymorphism of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase and prostate cancer risk: a prospective study.
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Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.
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