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Grant Details

Grant Number: 5R01CA054349-07 Interpret this number
Primary Investigator: Goldin, Barry
Organization: Tufts University Boston
Project Title: Estrogenic Plant Compounds and Etiology of Breast Cancer
Fiscal Year: 1998
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Abstract

The objective of this study is to determine the response of endogenous sex hormones to varying doses of soy derived isoflavonoids in pre- and postmenopausal women. Isoflavonoids have been associated with a number of factors which could result in a decreased incidence and/or progression of breast cancer. One of these factors which has been under investigation in our laboratory is the interaction of these phytoestrogens with the circulating levels of endogenous estrogen, sex hormone binding globulin and gonadotrophins. In the first two years of the current grant cycle it has been observed that feeding soy at a single dose alters plasma and urinary estrogen and gonadotrophin levels. More than a 30% decline in urinary estrogen excretion and a 20% decline in plasma estrogen level were noted upon feeding a soy drink. In this renewal application it is proposed to study the response of female sex hormone parameters to varying levels of orally administered isoflavonoids. These data will provide information that is necessary to evaluate the minimal dose of orally administered isoflavonoids required to achieve a significant and/or maximal effect on estrogen levels in plasma and urine. The amount of isoflavonoids excreted in the urine and the concentration plasma will also be studied to determine their response to the dose of isoflavanoids ingested orally. The relationship between urinary and plasma isoflavonoid concentration over a forty fold range of orally administered isoflavonoids will be evaluated to determine if urinary values can be used as a reliable indicator of plasma levels.

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Publications

The inhibition of the estrogenic effects of pesticides and environmental chemicals by curcumin and isoflavonoids.
Authors: Verma S.P. , Goldin B.R. , Lin P.S. .
Source: Environmental health perspectives, 1998 Dec; 106(12), p. 807-12.
PMID: 9831541
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Effect of soy-derived isoflavonoids on the induced growth of MCF-7 cells by estrogenic environmental chemicals.
Authors: Verma S.P. , Goldin B.R. .
Source: Nutrition and cancer, 1998; 30(3), p. 232-9.
PMID: 9631496
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Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts.
Authors: Fairchild R.L. , VanBuskirk A.M. , Kondo T. , Wakely M.E. , Orosz C.G. .
Source: Transplantation, 1997-06-27; 63(12), p. 1807-12.
PMID: 9210509
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Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides.
Authors: Verma S.P. , Salamone E. , Goldin B. .
Source: Biochemical and biophysical research communications, 1997-04-28; 233(3), p. 692-6.
PMID: 9168916
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Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets.
Authors: Schaefer E.J. , Lamon-Fava S. , Ausman L.M. , Ordovas J.M. , Clevidence B.A. , Judd J.T. , Goldin B.R. , Woods M. , Gorbach S. , Lichtenstein A.H. .
Source: The American journal of clinical nutrition, 1997 Mar; 65(3), p. 823-30.
PMID: 9062535
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Changes in plasma lipoprotein concentrations and composition in response to a low-fat, high-fiber diet are associated with changes in serum estrogen concentrations in premenopausal women.
Authors: Schaefer E.J. , Lamon-Fava S. , Spiegelman D. , Dwyer J.T. , Lichtenstein A.H. , McNamara J.R. , Goldin B.R. , Woods M.N. , Morrill-LaBrode A. , Hertzmark E. .
Source: Metabolism: clinical and experimental, 1995 Jun; 44(6), p. 749-56.
PMID: 7783659
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Overview: dietary approaches for reducing cardiovascular disease risks.
Authors: Dwyer J. .
Source: The Journal of nutrition, 1995 03; 125(3 Suppl), p. 656S-665S.
PMID: 7884548
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Nonsteroidal estrogens and estrogen antagonists: mechanism of action and health implications.
Authors: Goldin B.R. .
Source: Journal of the National Cancer Institute, 1994-12-07; 86(23), p. 1741-2.
PMID: 7966405
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Tofu and soy drinks contain phytoestrogens.
Authors: Dwyer J.T. , Goldin B.R. , Saul N. , Gualtieri L. , Barakat S. , Adlercreutz H. .
Source: Journal of the American Dietetic Association, 1994 Jul; 94(7), p. 739-43.
PMID: 8021414
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Hormone studies and the diet and breast cancer connection.
Authors: Goldin B.R. , Gorbach S.L. .
Source: Advances in experimental medicine and biology, 1994; 364, p. 35-46.
PMID: 7725958
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Diet and nutritional strategies for cancer risk reduction. Focus on the 21st century.
Authors: Dwyer J.T. .
Source: Cancer, 1993-08-01; 72(3 Suppl), p. 1024-31.
PMID: 8334654
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Fertile field for fads and fraud. Questionable nutritional therapies.
Authors: Dwyer J. .
Source: New York state journal of medicine, 1993 Feb; 93(2), p. 105-8.
PMID: 8455822
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