Grant Number:	1R01CA317445-01A1 Interpret this number
Primary Investigator:	Lu, Qian
Organization:	University Of Tx Md Anderson Can Ctr
Project Title:	Joy Luck Virtual Academy (JOY): a Culturally Centered Intervention
Fiscal Year:	2026

PROJECT SUMMARY/ABSTRACT Effective survivorship care is essential for improving post-treatment outcomes among cancer survivors in the United States. Cancer survivors who experience challenges during survivorship care often have higher unmet supportive care needs and reduced quality of life. Despite evidence that poorer quality of life is linked to shorter survival time, relatively few scalable psychosocial interventions have specifically targeted improving quality of life among cancer survivors with unmet supportive care needs. We propose a randomized controlled trial to test the health effects of a virtual peer mentoring and education intervention on quality of life among cancer survivors with ongoing supportive care needs after treatment. Participants will be randomly assigned to either a control condition in which they will watch health education videos and receive attention from research staff or an intervention condition in which they will receive peer mentoring and education support through four weekly virtual sessions. The intervention group will participate in facilitated discussions led by trained peer mentors who are themselves cancer survivors. The intervention group will also attend lectures addressing the physical and emotional aspects of cancer survivorship. Health outcomes will be assessed at baseline, immediately after the intervention, and at 4- and 12-month follow-ups. The primary outcome will be quality of life, and the secondary outcome will be depressive symptoms. This study will be one of the first randomized controlled trials to rigorously evaluate the health benefits of a virtual peer mentoring and education intervention designed to address survivorship challenges. If successful, the study will produce an evidence-based and scalable national program designed to improve quality of life in cancer survivors. This approach has the potential to shift current paradigms in survivorship care by introducing a replicable model of peer support. Because the intervention is virtual, peer-delivered, and structured around broadly relevant survivorship challenges, it is inherently generalizable and readily adaptable across cancer populations and health care settings, enabling broad impact. The anticipated impact includes the generation of actionable knowledge to inform future directions in cancer care delivery for patient populations in the U.S. and the improvement of survivorship support nationwide.




RAS-p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation.
Authors: Rosell A. , Krygowska A.A. , Alcón Pérez M. , Cuesta C. , Voisin M.B. , de Paz J. , Sanz-Fraile H. , Rajeeve V. , Carreras-González A. , Berral-González A. , et al. .
Source: Elife, 2025-04-24 00:00:00.0; 13, .
EPub date: 2025-04-24 00:00:00.0.
PMID: 40272400
Related Citations