Grant Number:	5U54CA280770-04 Interpret this number
Primary Investigator:	Pisu, Maria
Organization:	University Of Alabama At Birmingham
Project Title:	Center for Cancer Control in Persistent Poverty Areas (C3P2)
Fiscal Year:	2026

OVERALL ABSTRACT Cancer mortality, especially for obesity-related cancers like breast, prostate, and colorectal cancer, is higher in areas of the US affected by Persistent Poverty (PP), i.e., areas with a poverty rate of 20% or higher across four consecutive decennial censuses spanning 30 years (a formal geographic classification developed by the US Department of Agriculture and codified by Congress), compared to areas in which poverty has not persisted for decades. While reasons may be multifaceted, the role of the living environments in these areas cannot be overlooked: aspects of such environments (e.g., poor walkability and low social cohesion) have downstream effects on behaviors that impact health promotion and increase cancer risk and mortality. Multi-level interventions are necessary to mitigate these effects. In 2021, Alabama ranked 8th in the US for poverty. The state includes some of the most impoverished inner-city and rural communities in the nation, and thus a considerable number of both urban and rural Census Tracts (CTs) identified as PP areas by the National Cancer Institute (NCI). The overall goal of the University of Alabama at Birmingham (UAB) Center for Cancer Control in Persistent Poverty Areas (C3P2) is to reduce the burden of cancer and cancer disparities in PP areas by expanding research and research capacity through implementation and evaluation of multi-level interventions to improve cancer outcomes across the cancer control continuum from prevention to survivorship. The C3P2 goal will be achieved through: 1) Establishment and support of two transdisciplinary, multi-level, multi-domain research projects to adapt, implement, and evaluate multilevel interventions across the cancer control continuum from prevention to survivorship, as well as pilot projects through a Developmental Core; 2) Establishment of a coordinated C3P2 infrastructure to support and strengthen the C3P2 research agenda by: a) providing overall integrated management and comprehensive evaluation, b) providing common research resources and measures to promote project integration and collaboration (Administrative and Research and Methods Cores); 3) Development of a pipeline of investigators for cancer control research in PP areas by providing training, support, and research experience opportunity to early career investigators (Career Enhancement Core); 4) Academic-community partnership building with establishment of a Community Advisory Board and engagement of Community COaCHes to support innovative and salient research in the community, and monitoring and evaluation to ensure achievement of proposed goals. (Administrative Core). Our multi-disciplinary team of established and early career investigators, working in a supportive environment with the resources and commitment to address and challenges in PP areas to cancer prevention and control, are well positioned to make an impact in PP communities of Alabama and improve cancer outcomes. The C3P2 will serve as a model to improve cancer prevention and control for other PP areas in Alabama and other states.




Social and Legal Needs in Patients and Families With Cancer: Interaction With Patient-Level Financial Toxicity.
Authors: Anant S. , Jiang C. , Doran J. , Gany F. , Gupta A. , Rocque G.B. , Knight L.K. , Hussaini S.M.Q. .
Source: Jco Oncology Practice, 2025 Jan; 21(1), p. 41-51.
EPub date: 2025-01-10 00:00:00.0.
PMID: 39793548
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