Grant Number:	1R34CA300990-01A1 Interpret this number
Primary Investigator:	Benedict, Catherine
Organization:	Stanford University
Project Title:	Adaptation of a Family Building Decision Aid Tool for Young Adult Cancer Survivors
Fiscal Year:	2026

Project Summary/Abstract Among young adult (YA) cancer survivors, fertility is ranked as one of the most important and distressing concerns. Due to gonadotoxic cancer treatments, family building after cancer often requires the use of reproductive medicine or adoption, which have medical/physical, psychosocial, financial, legal, and logistical barriers. Roadmap to Parenthood (“Roadmap”) is an evidence-based, interactive decision aid and planning tool (website) for family building after cancer. It was developed for women who completed gonadotoxic cancer treatment. Across two pilot studies, Roadmap led to improvements in knowledge, self-efficacy, decisional conflict, and patient-provider communication. The proposed study aims to adapt and pilot test the Roadmap intervention to expand its application to address the family building needs of high-risk YA cancer survivors. First, adaptation of Roadmap will be guided by the ADAPT-ITT framework and a trauma-informed research approach, in partnership with our community collaborators and the community advisory board (CAB). Four focus groups with YA cancer survivors (N=32) will be conducted that will include “theater testing” intervention components to elicit qualitative feedback about adaptation. An initial prototype will be developed and usability testing with the target user population (N=10) will be conducted. Feedback from topic experts, community partners, and the community advisory board will be integrated using the Delphi method to make final decisions about modifications. Then, a single-arm pilot trial will examine feasibility, acceptability, and explore potential outcomes of the adapted Roadmap intervention to inform a future randomized clinical trial. Participants (N=40) will complete a baseline survey (T1) and then given access to the intervention website. Follow-up surveys at 1- and 3-month timepoints (T2 and T3, respectively) will be completed. Feasibility (rates of enrollment and completion) and acceptability (webpage metrics and brief exit survey) will be evaluated. We will explore whether potential outcome measures (decisional conflict, knowledge, self-efficacy, patient-provider communication, and stress) are responsive to the effects of the intervention at 1- and 3-month timepoints. The proposed research fulfills the NCI mission to improve the care of YA cancer survivors and responds to patient-reported priority areas. The adapted Roadmap intervention has the potential to improve access to family-building options for a broader population of YA cancer survivors.





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