Grant Number:	5U01CA265739-05 Interpret this number
Primary Investigator:	Wright, Jason
Organization:	Columbia University Health Sciences
Project Title:	Comparative Modeling for the Prevention and Control of Uterine Cancer
Fiscal Year:	2025

Uterine cancer is the 4th most common cancer in women and the 7th most frequent cause of cancer-related death. The death rate from uterine cancer is rising faster than for any other tumor. The overarching goal of this proposal is to inform cancer control and prevention strategies to reduce the incidence and mortality uterine cancer by improving the prevention, screening, and treatment of the disease. We will accomplish this goal through a collaborative modeling consortium in which three groups develop natural history models of uterine cancer. These models will incorporate known risk factors for uterine cancer and population level changes in the prevalence of these risk factors over time. The models will include pathways for both favorable prognosis (type I) uterine cancer as well as more aggressive (type II) neoplasms. Once developed and validated, we will perform comparative modeling to examine issues of importance to clinicians and policymakers. First, we will examine currently available and emerging strategies for screening and prevention of uterine cancer in women. Second, we will examine the harms, benefits, and cost-effectiveness of treatment strategies for uterine cancer including adjuvant therapy, treatment of metastatic disease, and treatment of recurrent disease including immunotherapy. Third, we will estimate how changing epidemiologic factors influence the incidence and mortality of uterine cancer. Fourth, we will explore the impact of the rising rate of obesity on incidence and mortality of uterine cancer and develop novel, web-based tools to determine how state-level obesity control activities influence incidence and mortality. Finally, we will explore how the declining hysterectomy rate and changing patterns of care for gynecologic diseases influence uterine cancer incidence and mortality. At the completion of this work, these data will be widely disseminated to patients, providers, and policy makers and have the potential to significantly impact the clinical care of women with uterine cancer and to guide cancer control strategies. Further, these models will serve as an invaluable resource for the uterine cancer community as new clinical questions and challenges emerge.




Projected Trends in the Incidence and Mortality of Uterine Cancer in the United States.
Authors: Wright J.D. , Prest M.T. , Ferris J.S. , Chen L. , Xu X. , Rouse K.J. , Melamed A. , Hur C. , Heckman-Stoddard B.M. , Samimi G. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2025-07-01 00:00:00.0; 34(7), p. 1156-1166.
PMID: 40589281
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Trends in uterine cancer incidence and mortality: insights from a natural history model.
Authors: Hazelton W.D. , Prest M. , Chen L. , Rouse K. , Elkin E.B. , Ferris J.S. , Xu X. , Bickell N.B. , Kong C.Y. , Blank S. , et al. .
Source: Journal Of The National Cancer Institute, 2025-06-13 00:00:00.0; , .
EPub date: 2025-06-13 00:00:00.0.
PMID: 40509873
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Glucagon-like-peptide-1 (GLP-1) receptor agonist use and the risk of pulmonary aspiration in patients undergoing surgery.
Authors: Wright J.D. , Chen L. , Xu X. , Hur C. , Matsuo K. , Elkin E.B. , Hershman D.L. .
Source: International Journal Of Surgery (london, England), 2025-06-01 00:00:00.0; 111(6), p. 4090-4093.
EPub date: 2025-05-12 00:00:00.0.
PMID: 40359555
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Current and Future Trends in Performance of Vaginal Hysterectomy in the United States.
Authors: Lerner V. , Chen L. , Xu X. , Myers E. , Wright J.D. .
Source: Obstetrics And Gynecology, 2025-05-22 00:00:00.0; , .
EPub date: 2025-05-22 00:00:00.0.
PMID: 40403305
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Ultrasound-based versus immediate biopsy-based management of postmenopausal bleeding in non-Hispanic Black and non-Hispanic White individuals.
Authors: Nolin A.C. , Atkins S.L. , Myers E.R. , Wentzensen N. , Clarke M.A. , Blank S.V. , Wright J.D. , Doll K.M. , Havrilesky L.J. .
Source: Gynecologic Oncology, 2025-02-21 00:00:00.0; 194, p. 105-111.
EPub date: 2025-02-21 00:00:00.0.
PMID: 39985869
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Optimization of Timing for Risk-Reducing Salpingectomy and Oophorectomy.
Authors: Pennington K.P. , Pugh S.L. , Huh W. , Walker J.L. , Jewell E. , Havrilesky L.J. , Carter J. , Muller C.Y. , Drapkin R. , Lankes H.A. , et al. .
Source: Obstetrics And Gynecology, 2025-01-01 00:00:00.0; 145(1), p. 21-30.
EPub date: 2024-11-07 00:00:00.0.
PMID: 39509704
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Weight-loss therapy in patients with obesity with endometrial intraepithelial neoplasia and uterine cancer.
Authors: Suzuki Y. , Chen L. , Matsuo K. , Ferris J.S. , Elkin E.B. , Melamed A. , Kong C.Y. , Bickell N. , Myers E.R. , Havrilesky L.J. , et al. .
Source: Gynecologic Oncology, 2024-08-19 00:00:00.0; 190, p. 78-83.
EPub date: 2024-08-19 00:00:00.0.
PMID: 39163750
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Trends in uterine cancer incidence in the United States: The contribution of age, period and cohort effects.
Authors: Ferris J.S. , Prest M.T. , Hur C. , Chen L. , Elkin E.B. , Melamed A. , Kong C.Y. , Myers E.R. , Havrilesky L.J. , Blank S.V. , et al. .
Source: Gynecologic Oncology, 2024-05-22 00:00:00.0; 187, p. 151-162.
EPub date: 2024-05-22 00:00:00.0.
PMID: 38781746
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Approaches to developing de novo cancer population models to examine questions about cancer and race in bladder, gastric, and endometrial cancer and multiple myeloma: the Cancer Intervention and Surveillance Modeling Network incubator program.
Authors: Sereda Y. , Alarid-Escudero F. , Bickell N.A. , Chang S.H. , Colditz G.A. , Hur C. , Jalal H. , Myers E.R. , Layne T.M. , Wang S.Y. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2023-11-08 00:00:00.0; 2023(62), p. 219-230.
PMID: 37947329
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