Grant Number:	5R01CA248216-05 Interpret this number
Primary Investigator:	Lu, Qian
Organization:	University Of Tx Md Anderson Can Ctr
Project Title:	Testing the Impact of a Multi-Level Intervention on Cancer Prevention Behavior Among Young Adults in Texas
Fiscal Year:	2025

Human papillomavirus (HPV) prevention medicine is important because it protects against cancers caused by HPV infection. Nearly 79 million people are currently infected in the United States and about 14 million people become infected with HPV each year. HPV infection can cause cancers and the financial burdens of these HPV-related diseases cost more than $8 billion per year in the US. Recently approved HPV prevention medicine can prevent up to 74% of HPV-associated invasive cancers. The Centers for Disease Control and Prevention (CDC) recommends HPV prevention medicine through age 26. Among adults18–26 years, HPV series completion is unacceptably low whereas HPV infection rates are unacceptably high. There is also a lack of interventions to improve HPV prevention medicine uptake among young adults who were not protected during childhood. This study aims to fill in the important gaps by using a 2 by 3 factorial design to test the independent and combined effects of a multilevel intervention: school-based HPV prevention services (no enhanced access vs. enhanced access) at the system level and web-based narratives (no enhanced access vs. video vs. written) at the individual level. This intervention is developed based on pilot studies and socio-ecological models that recognize the impact multi-level factors have on behaviors. The 2 by 3 factorial design results in six groups: standard CDC information about HPV prevention (control); 2) video narratives about HPV prevention; 3) written narratives about HPV prevention; 4) access to HPV prevention medicine at school combined with standard CDC information, 5) access to HPV prevention medicine at school combined with video narratives, or 6) access to HPV prevention medicine at school combined with written narratives . This design allows us to investigate the independent and combined effects of tailored narratives and access to school-based HPV prevention medicine on its uptake. College students aged 18-26 years who are not previously administered HPV prevention medicine will be randomly assigned to one of the six groups. Primary outcomes are series initiation and completion at 3- and 9-month follow-ups, respectively. This study has implications for creating a new paradigm in HPV prevention services by inspiring future new research directions that include targeting multi-level factors to improve the uptake of HPV prevention medicine. This study will make a significant positive impact on public health, as it is using evidence-based strategies tailored for young adults aged 18-26 years. If successful, the web-based intervention can be easily disseminated because it is brief and scalable. School-based HPV prevention services can be implemented on college campuses in the future to improve healthcare delivery. Success and lessons learned in this study will inform future strategies to develop tailored narrative messages for different groups.




Navigating Social Influences: The Impact of Anticipated HPV Vaccination Stigma from Friends and Family on College Students' HPV Vaccination Intent.
Authors: Pierce J.D. , Xu Y.A. , Hall N.A. , Anderson K.S. , Dawkins-Moultin L. , Wong-Meli C.C.Y. , Cho D. , Hopfer S. , Ramondetta L.M. , Li Y. , et al. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2025-09-02 00:00:00.0; 34(9), p. 1644-1655.
PMID: 40643569
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A multilevel intervention to promote HPV vaccination among young adults in Texas: protocol for a randomized controlled trial.
Authors: Lu Q. , Dawkins-Moultin L. , Cho D. , Tan N.Q.P. , Hopfer S. , Li Y. , Ramondetta L. , Xu Y. , Lun D. , Chen M. .
Source: Bmc Public Health, 2024-06-05 00:00:00.0; 24(1), p. 1506.
EPub date: 2024-06-05 00:00:00.0.
PMID: 38840086
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