Grant Number:	5R01CA033193-43 Interpret this number
Primary Investigator:	Schubauer-Berigan, Mary
Organization:	International Agency For Res On Cancer
Project Title:	Iarc Monographs on the Identification of Carcinogenic Hazards to Humans
Fiscal Year:	2025

Since 1971, the IARC Monographs on the Identification of Carcinogenic Hazards to Humans has provided an evidence-based approach to identifying the preventable causes of human cancer. Organizations worldwide rely on the IARC Monographs as a trustworthy source of carcinogenicity evaluations in their efforts to control cancer. Agents evaluated by the Monographs encompass chemicals, physical and biological agents, complex mixtures, occupational exposure circumstances, and other exposures of everyday life. To date, 1021 agents have been evaluated, with 121 classified as “carcinogenic”, 89 as “probably carcinogenic”, and 315 as “possibly carcinogenic” to humans. Agents are selected for evaluation based on evidence of human exposure and of carcinogenicity, and public health importance. Monographs are developed by independent global experts without conflicts of interest. Each Monograph includes systematic reviews of the pertinent scientific literature covering three unique streams of evidence (cancer in humans, cancer in experimental animals, and mechanistic evidence). The overall evaluations indicate the strength of the evidence that an agent or exposure may be carcinogenic to humans. These evidence evaluations are guided by a recently modernized Preamble, which emphasizes scientific rigor and transparency of the systematic review, updates the supporting methods, increases emphasis on mechanistic evidence, and advances an innovative method for integrating the three streams of evidence to produce robust overall classifications. The specific aims of this project are to: organize at least 10 Monographs meetings to evaluate candidate carcinogenic agents of high





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