Grant Number:	3R01CA263501-03S1 Interpret this number
Primary Investigator:	Quillin, John
Organization:	Virginia Commonwealth University
Project Title:	Understanding the Nature and Impact of Lgbtq+ Microaggressions in Cancer Genetic Counseling Encounters
Fiscal Year:	2024

Project Summary / Abstract Despite decades of effort to reduce racial cancer disparities, Black people continue to die at higher rates from cancer than any other U.S. racial group. Because prevention is the key to the cost-effective and long-term control of cancer, the potential for cancer genetic counseling to play a central role in reducing racial cancer disparities is high. However, the benefits of genetic counseling are not equitable across race. The overarching goal of this proposed research is to compare and contrast the nature of genetic counseling encounters and patient-centered outcomes between Black and White patients in the naturalistic clinical setting. Only 2% of genetic counselors self-identify as Black/African American, so most genetic counseling encounters with Black patients are racially discordant. Patients in racially discordant medical interactions tend to have poorer quality patient-provider communication and receive suboptimal clinical recommendations. One major factor that contributes to these racial healthcare disparities is racial bias. Drawing on findings from prior research, we hypothesize that genetic counselor providers’ greater implicit racial prejudice will be associated with poorer patient-provider communication, while providers’ explicit negative racial stereotypes will be associated with less comprehensive clinical discussion of cancer risk and genetic testing for Black (vs. White) patients. These disparities in encounters will be further associated with poorer patient-centered outcomes. We will test our hypotheses by addressing four specific aims: Aim 1) to compare/contrast the nature of patient-provider communication by patient race (Black or White); Aim 2) to compare/contrast the clinical discussion content by patient race; Aim 3) to quantify the role of each type of counselor bias in patient-provider communication (Aim 1) and clinical discussion content (Aim 2); and Aim 4) to quantify the role of patient-provider communication/ clinical discussion content with patient-centered outcomes (trust, satisfaction, therapeutic alliance, empowerment, genetic testing uptake). These aims will be achieved through an observational study with a convergent mixed methods research design. We will analyze recorded cancer genetic counseling encounters both qualitatively and quantitatively, linking those data to data from pre- and post-encounter surveys and medical chart reviews. With COVID-19, many genetic counseling encounters have moved to telehealth, and telehealth is expected to continue to thrive beyond the pandemic. The proposed study will embrace this unique, transitional opportunity and addresses the overarching goal in the naturalistic clinical setting through multiple modalities (in-person, telehealth). Findings from this multi-center study will highlight specific aspects of cancer genetic counseling encounters (patient- provider communication and clinical recommendations) that are directly associated with patient-centered outcomes. Patient-provider communication and clinical recommendations are modifiable factors, and they are already being taught in genetic counseling training programs; thus, the findings can have immediate impact on genetic counseling training and practice.





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