Grant Number:	4R37CA248665-06 Interpret this number
Primary Investigator:	Scott, Jessica
Organization:	Sloan-Kettering Inst Can Research
Project Title:	A Randomized Trial to Minimize Non-Response to Aerobic Training in Operable Breast Cancer
Fiscal Year:	2025

PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the primary cause of late mortality (death ≥5 yrs from diagnosis) in early breast cancer (EBC). Effective treatment strategies that improve function across multiple systems are needed in order to reduce CVD in EBC. Aerobic exercise therapy (AT) is a multisystem intervention demonstrated to improve cardiorespiratory fitness (CRF), a strong, independent predictor of CVD and all-cause mortality in breast and other malignancies. However, in our prior AT trial in EBC, our group found that despite high AT adherence, CRF change ranged from -10% to +24%, and ~60% of participants were classified as CRF non-responders. These findings indicate that AT following the conventional volume (~150 min/wk) and / or length (~16 wks) is insufficient for improving CRF in a substantial proportion of EBC survivors. The objective of the parent trial is therefore to evaluate the effects of increasing AT program length and volume on CRF response rate and other pertinent outcomes in EBC. We hypothesize that results from the parent trial will show that higher volume and length of AT will improve CRF response rate compared to standard dosing. However, we expect critical knowledge gaps will remain. The proposed R37 extension will allow us to address these gaps by further investigating CRF response to AT, the long-term effects of AT, and explore facilitators and barriers to AT. For the proposed extension, we will build on the funded parent trial by extending the follow-up of participants to 1-year post- intervention, providing a long-term assessment of CRF in the post-treatment survivorship period. We will address 3 specific aims: AIM 1: Examine baseline factors associated with CRF response. AIM 2: Evaluate the long-term effects of AT dosing on CRF and patient reported outcomes. AIM 3: Explore AT implementation outcomes. IMPACT: A history of cancer treatment is not a qualifying condition for structured AT and, as such, AT is not currently considered a standard aspect of cancer management. The proposed study will fill significant exercise- oncology knowledge gaps and will support AT implementation in clinical cancer care.




Leveraging Spaceflight to Advance Cardiovascular Research on Earth.
Authors: Scott J.M. , Stoudemire J. , Dolan L. , Downs M. .
Source: Circulation Research, 2022-03-18 00:00:00.0; 130(6), p. 942-957.
EPub date: 2022-03-17 00:00:00.0.
PMID: 35298305
Related Citations