Grant Details
Grant Number: |
5U01CA246570-03 Interpret this number |
Primary Investigator: |
Ness, Kirsten |
Organization: |
St. Jude Children'S Research Hospital |
Project Title: |
Telehealth Based Exercise Intervention to Improve Functional Capacity in Survivors of Childhood Cancer with Significantly Limited Exercise Tolerance |
Fiscal Year: |
2024 |
Abstract
Modified Project Summary/Abstract Section
Abstract
Survivors of childhood cancer in their thirties have exercise intolerance that mirrors values found among older
adults in the general population. Exercise intolerance among survivors substantially increases their risk for early
mortality, reduced cognitive function, poor quality of life, emotional distress, and sub-optimal participation in
social roles. Fortunately, exercise intolerance is modifiable, even among individuals with impaired cardiac,
pulmonary, and neuromuscular health. Nevertheless, survivors do not, on average, engage in exercise. Our
hypothesis is that regular exercise may be difficult and/or uncomfortable for childhood cancer survivors because
of underlying organ system impairments (specific impairment prevalence ranges from 15.5-37.7% in our eligible
population). The premise of this proposal is that tailored interventions, designed, and supervised by a
professional with appropriate expertise are necessary to help survivors with significant impairment feel
comfortable and gain confidence with exercise and physical activity. These interventions need to be delivered in
a way that both incorporates the initial supervision and advice that these survivors need, while minimizing
disruption in their daily lives. This proposal tests the efficacy of an individually prescribed exercise intervention
on exercise tolerance, with initial instruction provided at one clinical visit, and subsequent supervision and
exercise progression provided remotely. This study, using an experienced multidisciplinary team (exercise
physiology, psychology, cardiology, internal medicine, oncology, survivorship, implementation science experts),
if effective, will move standard of care (encouraging physical activity) for exercise intolerance from its’ current
state, where it is ineffective for many survivors, to a clinically actionable, practical, sustainable, relatively low
cost, and generalizable intervention.
Publications
Design and methods of a randomized telehealth-based intervention to improve fitness in survivors of childhood Cancer with exercise intolerance.
Authors: Maharaj A.
, Jefferies J.L.
, Mulrooney D.A.
, Armstrong G.T.
, Brinkman T.M.
, O'Neil S.T.
, Terrell S.
, Partin R.E.
, Srivastava D.K.
, Hudson M.M.
, et al.
.
Source: Contemporary Clinical Trials, 2023-09-18 00:00:00.0; 133, p. 107339.
EPub date: 2023-09-18 00:00:00.0.
PMID: 37730199
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